The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells

Free Radical Research

Volumn 40, Issue 9, 2006, Pages 974-978

  Hasinoff, Brian B ^a   Begleiter, Asher ^b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Cytochrome P450 reductase; EPR; Hydroxyl radical; Quinone; RH1; Semiquinone radical

Indexed keywords

2,5 DIAZIRIDINYL 3 (HYDROXYMETHYL) 6 METHYL 1,4 BENZOQUINONE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; CATALASE; DEFERASIROX; DOXORUBICIN; FREE RADICAL; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; RH 1; SEMIQUINONE; SUPEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL HYPOXIA; COLON CANCER; CONTROLLED STUDY; DRUG ACTIVATION; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; ELECTRON SPIN RESONANCE; HUMAN; HUMAN CELL; MAGNETIC FIELD; OXIDATION REDUCTION REACTION; PATIENT SELECTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; AZIRIDINES; BENZOQUINONES; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; MOLECULAR STRUCTURE; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; QUINONES;

EID: 33749265694     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760600833077     Document Type: Article

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