Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern. 4. Synthesis and biological activity of 2-chloro-3- (substituted phenoxy)-1,4-naphthoquinones and related 5,8-dihydroxy-1,4- naphthoquinones

Journal of Medicinal Chemistry

Volumn 42, Issue 3, 1999, Pages 405-408

  Chang, He Xi ^a   Chou, Ting Chao ^b   Savaraj, Niramol ^c   Liu, Leroy F ^d   Yu, Chiang ^d   Cheng, C C ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,7,10 TETRAHYDROXYBENZO[B]NAPHTHO[2,3 D]FURAN 6,11 DIONE; 1,4 NAPHTHOQUINONE DERIVATIVE; 2 CHLORO 5,8 DIMETHOXY 3 (3,5 DIMETHOXYPHENOXY) 1,4 NAPHTHOQUINONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; NAPHTHALENES; NAPHTHOQUINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032972439     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9804679     Document Type: Article

References (12)

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3. (a) Cheng, C. C.; Liu, D. F.; Chou, T. C. Design of Antineoplastic Agents on the Basis of the "2-Phenylnaphthalene-type" Structural Pattern. I. Synthesis of Substituted 3-Phenylquinazolones, Benzoxazolo[2,3-b]quinazolones and benzothiazolo[2,3-b]quinazolones. Heterocycles 1993, 35, 775-789.
4. (b) Cheng, C. C.; Dong, Q.; Liu, D. F.; Luo, Y. L.; Liu, L. F.; Chen, A. Y.; Yu, C.; Savaraj, N.; Chou, T. C. Design of Antineoplastic Agents on the Basis of the "2-Phenylnaphthalene-type" Structural Pattern. 2. Synthesis and Biological Activity Studies of Benzo[b]naphtho[2,3-d]furan-6,11-dione Derivatives. J. Med. Chem. 1993, 36, 4108-4112.
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