DD-ligases as a potential target for antibiotics: Past, present and future

Current Medicinal Chemistry

Volumn 16, Issue 20, 2009, Pages 2566-2580

  Tytgat, I ^a   Colacino, E ^a,c   Tulkens, P M ^a   Poupaert, J H ^a   Prevost M ^b   van Bambeke, F ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

Antibiotic; D cycloserine; DD ligase; Peptidoglycan; Phosphinophosphate

Indexed keywords

(3 AMINO 2 OXOBUTYL)PHOSPHONIC ACID; (BETA BETA DICHLORO ALPHA AMINOETHYL)PHOSPHONIC ACID; ALANINE (1 AMINOETHYL)BORONIC ACID; AMINO ACID ISOSTER 1 (AMINOETHYL)PHOSPHINIC ACID; ANTIBIOTIC AGENT; CYCLOSERINE; DEXTRO (1 AMINOETHYL)PHOSPHONIC ACID; DEXTRO ALANYL DEXTRO ALANINE LIGASE; DEXTRO ALANYL DEXTRO ALANINE LIGASE INHIBITOR; DEXTRO ALANYL DEXTRO LACTATE LIGASE; ENZYME INHIBITOR; GLUTAMINE; LIGASE; N ACETYLMURAMIC ACID PENTAPEPTIDE; PENTAPEPTIDE; PEPTIDOGLYCAN; PHOSPHINODIPEPTIDE DERIVATIVE; TEICOPLANIN; TYROSINE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLMURAMIC ACID PENTAPEPTIDE; VANCOMYCIN;

AMINO TERMINAL SEQUENCE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; ENTEROCOCCUS FAECIUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HIGH THROUGHPUT SCREENING; LEUCONOSTOC MESENTEROIDES; LIGAND BINDING; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHASE TRANSITION; REVIEW; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

EID: 70349404122     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709788682029     Document Type: Review

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