Control of peptidoglycan synthesis in vancomycin-resistant enterococci: D,D-peptidases and D,D-carboxypeptidases

Cellular and Molecular Life Sciences

Volumn 54, Issue 4, 1998, Pages 325-331

  Reynolds, P E ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

D,D carboxypeptidase; Enterococci; Peptidoglycan; Resistance; Vancomycin

Indexed keywords

ANTIBIOTIC AGENT; CARBOXYPEPTIDASE; GLYCOPEPTIDE; PEPTIDASE; PEPTIDOGLYCAN; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; BIOSYNTHESIS; CONFERENCE PAPER; ENTEROCOCCUS; ENZYME SPECIFICITY; HYDROLYSIS; NONHUMAN; TRANSPOSON;

AMINO ACID SEQUENCE; CARBOXYPEPTIDASES; DRUG RESISTANCE, MICROBIAL; ENTEROCOCCUS; MOLECULAR SEQUENCE DATA; PEPTIDOGLYCAN; SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE; VANCOMYCIN;

ENTEROCOCCUS;

EID: 0031899463     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000180050159     Document Type: Conference Paper

References (18)

1. Arthur M., Reynolds P. E. and Courvalin P. (1996) Glycopeptide resistance in enterococci. Trends Microbiol. 4: 401-407
2. Arthur M., Molinas C. and Courvalin P. (1992) The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J. Bacteriol. 174: 2582-2591
3. Allen N. E. and Hobbs J. N. Jr. (1995) Induction of vancomycin resistance in Enterococcus faecium by non-glycopeptide antibiotics. FEMS Microbiol. Lett. 132: 107-114
4. Baptista M., Depardieu F., Courvalin P. and Arthur M. (1996) Specificity of induction of glycopeptide resistance genes in Enterococcus faecalis. Antimicrob. Agents Chemother. 40: 2291-2295
5. Ulijasz A. T., Grenader A. and Weisblum B. (1996) A vancomycin-inducible lacZ reporter system in Bacillus subtilis: induction by antibiotics that inhibit cell wall synthesis and by lysozyme. J. Bacteriol. 178: 6305-6309
6. Bugg T. D. H., Wright G. D., Dutka-Malen S., Arthur M., Courvalin P. and Walsh C. T. (1991) Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry 30: 10408-10415
7. Park I.-S., Lin C.-H. and Walsh C. T. (1996) Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl:D-alanine ligase B. Biochemistry 35: 10464-10471
8. Reynolds P. E., Depardieu F., Dutka-Malen S., Arthur M. and Courvalin P. (1994) Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine. Mol. Microbiol. 13: 1065-1070
9. Arthur M., Depardieu F., Snaith H. A., Reynolds P. E. and Courvalin P. (1994) Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors. Antimicrob. Agents Chemother. 38: 1899-1903
10. Arthur M., Depardieu F., Reynolds P. E. and Courvalin P. (1996) Quantitative analysis of the metabolism of soluble cytoplasmic precursors of glycopeptide-resistant enterococci. Mol. Microbiol. 21: 33-44
11. Quintiliani R. Jr. and Courvalin P. (1996) Characterisation of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecalis BM4281. Gene 172: 1-8
12. Reynolds P. E., Snaith H. A., Maguire A. J., Dutka-Malen S. and Courvalin P. (1994) Analysis of peptidoglycan precursors in vancomycin-resistant Enterococcus gallinarum BM4174. Biochem. J. 301: 5-8
13. Billot-Klein D., Gutmann L., Sable S., Guittet E. and van Heijenoort J. (1994) Modification of peptidoglycan precursors is a common feature of the low-level resistant VANB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroides and Enterococcus gallinarum. J. Bacteriol. 176: 2398-2405
14. Dutka-Malen S., Molinas C., Arthur M. and Courvalin P. (1992) Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance. Gene 112: 53-58
15. Billot-Klein D., Blanot D., Gutmann L. and van Heijenoort J. (1994) Association constants for the binding of vancomycin and teicoplanin to N-acetyl-D-alanyl-D-alanine and N-acetyl-D-alanyl-D-serine. Biochem. J. 304: 1021-1022
16. Evers S., Quintiliani R. Jr. and Courvalin P. (1996) Genetics of glycopeptide resistance in enterococci. Microb. Drug Resist. 2: 219-223
17. McCafferty D. G., Lessard I. and Walsh C. T. (1997) Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. Biochemistry 36: 10498-10505
18. 2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5Å resolution. Nature 299: 469-470