A de novo designed inhibitor of D-ala-D-Ala ligase from E. coli

Angewandte Chemie - International Edition

Volumn 44, Issue 39, 2005, Pages 6403-6406

  Besong, Gilbert E ^a   Bostock, Julieanne M ^a   Stubbings, Will ^a   Chopra, Ian ^a   Roper, David I ^b   Lloyd, Adrian J ^b   Fishwick, Colin W G ^a   Johnson, A Peter ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Inhibitors; Ligases; Medicinal chemistry; Molecular modeling; Molecular recognition

Indexed keywords

CRYSTAL STRUCTURE; ENZYMES; SYNTHESIS (CHEMICAL); X RAYS;

BACTERIAL ENZYMES; MOLECULAR DESIGNS; X-RAY CRYSTAL STRUCTURES;

ESCHERICHIA COLI;

CYCLOPROPANE; CYCLOPROPANE DERIVATIVE; D-ALANYLALANINE SYNTHETASE; DEXTRO ALANINE DEXTRO ALANINE LIGASE; ENZYME INHIBITOR; PEPTIDE SYNTHASE;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; CONFORMATION; DRUG ANTAGONISM; ENZYMOLOGY; ESCHERICHIA COLI; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLOPROPANES; ENZYME INHIBITORS; ESCHERICHIA COLI; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDE SYNTHASES; PROTEIN CONFORMATION; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26844437323     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200501662     Document Type: Article

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