Peptidoglycan biosynthesis: Unexploited antibacterial targets within a familiar pathway

Advances in Experimental Medicine and Biology

Volumn 456, Issue , 1998, Pages 197-217

  Wong, K K ^a   Pompliano, D L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; FOSFOMYCIN; FOSFOMYCIN TROMETAMOL; LIGASE; PEPTIDOGLYCAN; PYRUVATE OXIDASE; RACEMASE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; DRUG TARGETING; ENZYME KINETICS; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0032226551     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-4897-3_11     Document Type: Review

References (84)

1. Bacterial plasmids and gene flux
2. Evaluation of 5-enolpyruvoylshikimate-3-phosphate synthase substrate and inhibitor binding by stopped-flow and equilibrium fluorescence measurements
3. Kineic and structural analysis of enzyme intermediates: Lessons from EPSP synthase
4. Kinetic mechanism of the Escherichia coli UDPMurNAc-tripeptide D-alanyl-D-anlanine-adding enzyme: Use of a glutathione S-transferase fusion
5. Spectroscopic properties of Escherichia coli UDP-N-acetylpyruylglucosamine reductase
6. Role of penicillin-binding proteins of Staphylococcus aureus in the induction of bacteriolysis
7. An enzyme-substrate complex involved in bacterial cell wall biosynthesis
8. The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell walls
9. Fosfomycin resistance protein (FosA) is a manganese metalloglutathione transferase related to glyoxalase 1 and the extradiol dioxygenases
10. Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli
11. Ultrastructure, chemistry and function of the bacterial cell wall
12. Invariant amino acids in the Mur peptide synthetases of bacterial peptidoglycan synthesis and their modification by site-directed mutagenesis in the UDP-MurNAc:L-alanine ligase from Escherichia coli
13. MurA(MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis is essential in Escherichia coli
14. Intracellular steps of bacterial cell wall peptidoglycan biosynthesis: Enzymology, antibiotic, and antibiotic resistance
15. Purification and mechanism of action of proline racemase
16. Synergy of fosfomycin with beta-lactam antibiotics against staphylococci and aerobic gram-negative bacilli
17. New approaches to the control of infections caused by antibiotic-resistant bacteria
18. New directions in antibacterial research
19. Origins, acquisition, and dissemination of antibiotic resistance determinants
20. Single-dose fosfomycin trometamol (Monuril) versus multiple-dose norfloxacin: Results of a multicenter study in females with uncomplicated lower urinary tract infections
21. New targets and strategies for the development of antibacterial agents
22. Steady-sate kinetic mechanism of Escherichia coli UDP-N-acetylenolpyruvyl-glucosamine reductase
23. ATP-dependent inactivation and slow binding inhibition of Salmonella typhimurium D-alanine:D-alanine ligase (ADP) by aminoalkyl)phosphinate and aminophosphonate analogues of D-alanine
24. (1-Aminoethyl)boronic acid: A novel inhibitor for Bacillus stearothermophilus alanine racemase and Salmonella typhimurium D-alanine:D-alanine ligase
25. Kinetic and crystallographic studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligase
26. Conditional lethal Escherichia coli murein mutants contain point defects that map to regions conserved among murein and folyl poly-γ-glutamate ligases: Identification of a ligase superfamily
27. Biochemical evidence for the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction
28. Localizing the NADP+ binding site on the MurB enzyme by NMR
29. The discovery of cell wall active antibacterial antibiotics
30. Purification, cloning, and cofactor independence of glutamate racemase from Lactobacillus
31. Mechanism of the reaction catalyzed by glutamate racemase
32. Inhibitors of the bacterial cell wall biosynthesis enzyme MurD
33. Major surface antigen p190 of Plasmodium falciparum: Detection of common epitopes present in a variety of Plasmodia isolates
34. The intensive care unit: The hottest zone
35. Spontaneous point mutations that occur more often when advantageous than when neutral
36. UDP-N-acetylmuramyl-L-alanine functions as an activator in the regulation of the Escherichia coli glutamate racemase activity
37. Drug synthesis by genetically engineered microorganisms
38. Homology among MurC, MurD, MurE and MurF proteins in Escherichia coli and that between E. coli MurG and a possible MurG protein in Bacillus subtilis
39. Structural studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligase
40. The mechanism of action of fosfomycin (phosphonomycin)
41. Dispensability of either penicillin-binding protein-1a or -1b involved in the essential process for cell elongation in Escherichia coli
42. Combinatorial chemistry and biology: An opportunity for engineers
43. Kinetic characterization of the inactivation of UDP-GlcNAc-enoylpyruvyl transferase by (Z)-3-fluorophosphoenol-pyruvate: Evidence for two oxocarbenium ion intermediates in enolpyruvl transfer catalysis
44. Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNac enolpyruvyl transferae (MurA) that confers resistence to inactivation by the antibiotic fosfomycin
45. New strategies for antibacterial drug design
46. Synthesis of new peptide inhibitors of the mesodiaminopimelate-adding enzyme
47. Analysis of the enol ether transfer catalyzed by UDP-GlcNac enolpyruvyl transferase using (E)- and (Z)-isomers of phosphoenolbutyrate: Sterochemical, partitioning and isotope effect studies
48. (E)-Enolbutyryl-UDP-N-acetylglucosamine as a mechanistic probe of UDP-N-acetylenolpyruvylglucosamine reductase (MurB)
49. 14C]acetylglucosamine
50. Murein synthesis and identification of cell wall precursors of temperature-sensitive lysis mutants of Escherichia coli
51. Temperature-sensitive mutant of Escherichia coli K-12 with low activities of the L-alanine adding enzyme and the D-alanyl-D-alanine adding enzyme
52. Temperature-sensitive mutant of Escherichia coli K-12 with an impaired D-alanine:D-alanine ligase
53. On the mechanism of action of the antibiotic O-carbamyl-d-serine in Streptococcus faecalis
54. An Escherichia coli vector to express and purify foreign proteins by fusion to and separation from maltose-binding protein
55. Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enoylpyruvoyl transferase by the antibiotic fosfomycin
56. Aminoalkylphosphinate inhibitors of D-ala-D-ala adding enzyme
57. Monuril in lower uncomplicated urinary tract infection in adults
58. Preparation and characterization of uridinediphosphate-N-acetylmuramyl-L-alanyl-D-glutamyl-meso-2,6- diaminopimelic acid
59. Inhibition of cell wall biosyntheisis by analogues of alanine
60. A molecular view of microbial diversity and the biosphere
61. Phosphinic acid inhibitors of D-alanyl-D-alanine ligase
62. High-level expression of soluble protein in Escherichia coli using a His6-tag and maltose-binding-protein double-affinity fusion system
63. The biochemical mechanism of resistance by streptococci to the antibiotic D-cycloserine and O-carbamyl-D-serine
64. Adaptive mutations produce resistance to ciprofloxacin
65. Reaction mechanism and structure of the active site proline racemase
66. Crystal structure of UDP-N-acetylglucoamine enolpyruvatetransferase, the target of the antibiotic fosfomycin
67. Current approaches to overcome bacterial resistance
68. Screening of natural products for antimicrobial agents
69. Discovery and development of new antibiotics: The problem of antibiotic resistance
70. Structure and topological symmetry of the glyphosate target 5-enol-pyruvaylshikimate-3-phosphate synthase: A distinctive protein fold
71. 5-Enolpyruvylshikimate-3-phosphate synthase of Klehsiella pneumoniae 2. Inhibition by glyphosate [N-(phosphonomethyl)glycine]
72. Plasmid-encoded fosfomycin resistance
73. Hospital-acquired infections: Diseases with increasingly limited therapies
74. Phosphinate inhibitor of the D-glutamate acid-adding enzyme of peptidoglycan biosynthesis
75. Isotope effects and the identification of catalytic residues in the reaction catalyzed by glutamate racemase
76. Inhibition of phosphoenoylpyruvate:uridine diphosphate N-acetylglucoseamine enoylpyruvyl transferase by uridine diphosphate N-acetylmuramyl peptides
77. Enzymes in the D-alanine branch of bacterial cell wall peptidoglycan assembly
78. Bacterial resistance to vancomycin: Five genes and one missing hydrogen bond tell the story
79. Evidence that the reaction of the UDP-N-acetylglucoamine 1-carboxyvinyl-transferase proceeds through the O-phosphothioketal of pyruvic acid bound to Cys115 of the enzyme
80. Partial purification and properties of the pyruvate-uridine diphospho-N-acetylglucosamine transferase from Staphylococcus epidermidis
81. Pyruvate-uridine diphospho-N-acetylglucosamine transferase: Purification to homogeneity and feedback inhibition