Inhibition of human two-pore domain K+ channel TREK1 by local anesthetic lidocaine: Negative cooperativity and half-of-sites saturation kinetics

Molecular Pharmacology

Volumn 76, Issue 4, 2009, Pages 903-917

  Nayak, Tapan K ^a   Harinath, S ^a   Nama, S ^a   Somasundaram, K ^a   Sikdar, Sujit K ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HETERODIMER; LIDOCAINE; POTASSIUM CHANNEL; PROTEIN KINASE; PROTEIN TREK1; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; DELETION MUTANT; DRUG EFFECT; DRUG INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOICHIOMETRY;

AMINO ACID SEQUENCE; ANESTHETICS, LOCAL; CELL LINE; DIMERIZATION; HUMANS; KINETICS; LIDOCAINE; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 70349315077     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.056838     Document Type: Article

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