Inhibition of human TREK-1 channels by bupivacaine

Anesthesia and Analgesia

Volumn 96, Issue 6, 2003, Pages 1665-1673

  Punke, Mark A ^a   Licher, Thomas ^b   Pongs, Olaf ^b   Friederich, Patrick ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; POTASSIUM CHANNEL;

ACIDOSIS; ANIMAL CELL; ARTICLE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG PROTEIN BINDING; GENETIC TRANSFECTION; HUMAN; HYPERPOLARIZATION; MEMBRANE POTENTIAL; NERVE CELL; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE CONDUCTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TREK 1 CHANNEL;

EID: 0038024382     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000062524.90936.1F     Document Type: Article

References (29)

1. Lesage F, Lazdunski M. Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol 2000;279:F793-801.
2. Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N. Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci 2001;2:175-84.
3. + channels. Anesthesiology 2001;95:1013-21.
4. + channels. Trends Neurosci 2001;24:339-46.
5. Meadows HJ, Benham CD, Cairns W, et al. Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel. Pflugers Arch 2000;439:714-22.
6. Medhurst AD, Rennie G, Chapman CG, et al. Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Brain Res Mol Brain Res 2001;86:101-14.
7. Butterworth JF IV, Strichartz GR. Molecular mechanisms of local anesthesia: a review. Anesthesiology 1990;72:711-34.
8. Drachman D, Strichartz G. Potassium channel blockers potentiate impulse inhibition by local anesthetics. Anesthesiology 1991;75:1051-61.
9. Brau ME, Nau C, Hempelmann G, Vogel W. Local anesthetics potently block a potential insensitive potassium channel in myelinated nerve. J Gen Physiol 1995;105:485-505.
10. Kindler CH, Yost CS, Gray AT. Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem. Anesthesiology 1999;90:1092-1102.
11. Friederich P, Benzenberg D, Urban BW. Bupivacaine inhibits human neuronal Kv3 channels in SH-SY5Y human neuroblastoma cells. Br J Anaesth 2002;88:864-6.
12. Dilger JP. Basic pharmacology of inhalational anesthetics agents. In: Bowdle TA, Horita A, Kharasch ED, eds. The pharmacological basis of anesthesiology. New York: Churchill Livingstone, 1994:497-521.
13. Maingret F, Patel A, Lesage F, et al. Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem 1999;274:26691-6.
14. Hamill OP, Marty A, Neher E, et al. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981;391:85-100.
15. Fakler B, Schultz JH, Yang J, et al. Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH. EMBO J 1996;15:4093-9.
16. Winne D. Sequential statistical trials in medicine. Arzneimittelforschung 1965;15:1088-91.
17. Motulsky H. Graph pad guide to nonlinear regression. San Diego, CA: GraphPad Software, 1996.
18. Hille B. Introduction. In: Hille B, ed. Ion channels of excitable membranes. 3rd ed. Sunderland, MA: Sinauer Associates, 2001:1-22.
19. Paton WD, Waud DR. The margin of safety of neuromuscular transmission. J Physiol 1967;191:59-90.
20. Merck index: an encyclopedia of chemicals, drugs and biologicals. 12th ed. Whitehouse Station, NJ: Merck & Co., 1996.
21. + channel. EMBO J 1998;17:4283-90.
22. Urban BW, Friederich P. Local anaesthetics-toxicity. In: Schulte am Esch J, Scholz J, Tonner P, eds. Molecular pharmacology of anaesthesia. Lengerich: Pabst Science Publishers, 2000:151-63.
23. Feldman HS, Arthur GR, Covino BG. Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. Anesth Analg 1989;69:794-801.
24. Tucker GT. Pharmacokinetics of local anaesthetics. Br J Anaesth 1986;58:717-31.
25. Hille B. Classical mechanisms of block. In: Hille B, ed. Ion channels of excitable membranes. 3rd ed. Sunderland, MA: Sinauer Associates, 2001:503-37.
26. Knudsen K, Beckman Suurkula M, Blomberg S, et al. Central nervous and cardiovascular effects of IV infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth 1997;78:507-14.
27. Cox CR, Faccenda KA, Gilhooly C, et al. Extradural S(-)bupivacaine: comparison with racemic RS-bupivacaine. Br J Anaesth 1998;80:289-93.
28. Huang YF, Pryor ME, Mather LE, Veering BT. Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. Anesth Analg 1998;86:797-804.
29. Nau C, Vogel W, Hempelmann G, Brau ME. Stereoselectivity of bupivacaine in local anesthetic-sensitive ion channels of peripheral nerve. Anesthesiology 1999;91:786-95.