Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age

Mechanisms of Ageing and Development

Volumn 130, Issue 9, 2009, Pages 637-647

  Simon, Kirk ^a   Mukundan, Anju ^a   Dewundara, Samantha ^a   Van Remmen, Holly ^b,c   Dombkowski, Alan A ^a   Cabelof, Diane C ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^c University of Texas Health Science Center   (United States)

Author keywords

Aging; Cell cycle; DNA damage response; DNA repair; p53

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; BRCA2 PROTEIN; CYCLINE; DIHYDROFOLATE REDUCTASE; DNA; DNA DIRECTED DNA POLYMERASE DELTA; DNA PRIMASE; DOUBLE STRANDED DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; K RAS PROTEIN; P21 ACTIVATED KINASE 3; POLO LIKE KINASE 3; PROTEIN KINASE; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH3; PROTEIN MSH6; PROTEIN P21; PROTEIN P53; PROTEIN RAD1; PROTEIN TIMELESS; RAD51 PROTEIN; RAD52 PROTEIN; REV PROTEIN; THIOREDOXIN; THYMIDINE KINASE; TRANSCRIPTION FACTOR E2F6; XRCC1 PROTEIN; ZINC FINGER PROTEIN;

AGING; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL FRACTIONATION; CELL NUCLEUS; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; GENE EXPRESSION; GENETIC REGULATION; GENETIC TRANSCRIPTION; GENOTOXICITY; MALE; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; UNINDEXED SEQUENCE; UPREGULATION;

AGING; ANIMALS; APOPTOSIS; CARCINOGENS; CELL CYCLE; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; NITROPARAFFINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROPANE; REPRODUCIBILITY OF RESULTS; SPECIFIC PATHOGEN-FREE ORGANISMS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS;

EID: 69949108377     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2009.07.007     Document Type: Article

References (50)

1. Bakkenist C.J., Drissi R., Wu J., Kastan M.B., and Dome J.S. Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. Cancer Res. 64 (2004) 3748-3752
2. Besson A., Assoian R.K., and Roberts J.M. Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?. Nat. Rev. Cancer 4 (2004) 948-955
3. Bohr V.A., and Anson R.M. DNA damage, mutation and fine structure DNA repair in aging. Mutat. Res. 338 (1995) 25-34
4. Cabelof D.C., Ikeno Y., Nyska A., Busuttil R.A., Anyangwe N., Vijg J., Matherly L.H., Tucker J.D., Wilson S.H., Richardson A., and Heydari A.R. Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Cancer Res. 66 (2006) 7460-7465
5. Cabelof D.C., Raffoul J.J., Ge Y., Van Remmen H., Matherly L.H., and Heydari A.R. Age-related loss of the DNA repair response following exposure to oxidative stress. J. Gerontol. A: Biol. Sci. Med. Sci. 61 (2006) 427-434
6. Cabelof D.C., Raffoul J.J., Yanamadala S., Ganir C., Guo Z., and Heydari A.R. Attenuation in DNA polymerase β-dependent base excision repair pathway and increased DMS induced mutagenicity in aged mice. Mutat. Res. 500 (2002) 135-145
7. Cabelof D.C., Raffoul J.J., Yanamadala S., Guo Z., and Heydari A.R. Induction of DNA polymerase beta-dependent base excision repair in response to oxidative stress in vivo. Carcinogenesis 23 (2002) 1419-1425
8. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 12 (2005) 513-522
9. Chou D.M., and Elledge S.J. Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 18143-18147
10. Coppe J.P., Patil C.K., Rodier F., Sun Y., Munoz D.P., Goldstein J., Nelson P.S., Desprez P.Y., and Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6 (2008) e301
11. d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., Fiegler H., Carr P., Von Zglinicki T., Saretzki G., Carter N.P., and Jackson S.P. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426 (2003) 194-198 (EMBO J. 20, 914-923)
12. Fang G., Yu H., and Kirschner M.W. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev. 12 (1998) 1871-1883
13. Feng Z., Hu W., Teresky A.K., Hernando E., Cordon-Cardo C., and Levine A.J. Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 16633-16638
14. Gotter A.L., Suppa C., and Emanuel B.S. Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. J. Mol. Biol. 366 (2007) 36-52
15. Goukassian D., Gad F., Yaar M., Eller M.S., Nehal U.S., and Gilchrest B.A. Mechanisms and implications of the age-associated decrease in DNA repair capacity. FASEB J. 14 (2000) 1325-1334
16. Guo Z., Wang M., Tian G., Burger J., Gochfeld M., and Yang C.S. Age- and gender-related variations in the activities of drug-metabolizing and antioxidant enzymes in the white-footed mouse (Peromyscus leucopus). Growth Dev. Aging 57 (1993) 85-100
17. Hamadeh H.K., Trouba K.J., Amin R.P., Afshari C.A., and Germolec D. Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes. Toxicol. Sci. 69 (2002) 306-316
18. Intano G.W., Cho E.J., McMahan C.A., and Walter C.A. Age-related base excision repair activity in mouse brain and liver nuclear extracts. J. Gerontol. A: Biol. Sci. Med. Sci. 58 (2003) 205-211
19. Ivancsits S., Diem E., Jahn O., and Rudiger H.W. Age-related effects on induction of DNA strand breaks by intermittent exposure to electromagnetic fields. Mech. Ageing Dev. 124 (2003) 847-850
20. Kaneko T., Tahara S., Tanno M., and Taguchi T. Age-related changes in the induction of DNA polymerases in rat liver by gamma-ray. Mech. Ageing Dev. 123 (2002) 1521-1528
21. Katsure Y., Sasaki S., Sato M., Yamaoka K., Suzukawa K., Nagasawa T., Yokota J., and Kohno T. Involvement of Ku80 in microhomology-mediated end joining for DNA double-strand breaks in vivo. DNA Repair 6 (2007) 639-648
22. Kho P.S., Wang Z., Zhuang L., Li Y., Chew J.L., Ng H.H., Liu E.T., and Yu Q. p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. J. Biol. Chem. 279 (2004) 21183-21192
23. Kim K.S., Kang K.W., Seu Y.B., Baek S.H., and Kim J.R. Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells. Mech. Ageing Dev. 130 (2009) 179-188
24. Kujoth G.C., Hiona A., Pugh T.D., Someya S., Panzer K., Wohlgemuth S.E., Hofer T., Seo A.Y., Sullivan R., Jobling W.A., Morrow J.D., Van Remmen H., Sedivy J.M., Yamasoba T., Tanokura M., Weindruch R., Leeuwenburgh C., and Prolla T.A. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309 (2005) 481-484
25. Leakey J.A., Cunny J., Bazasre J., Webb P.J., Feuers R.J., Duffy P.H., and Hart R.W. Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the fisher 344 rat. I. The cytochrome P-450 dependent monooxygenase system. Mech. Ageing Dev. 48 (1989) 145-155
26. Medvedev Z.A. Age-related polyploidization of hepatocytes: the cause and possible role. A mini-review. Exp. Gerontol. 21 (1986) 277-282
27. O'Reilly P.G., Wagner S., Franks D.J., Cailliau K., Browaeys E., Dissous C., and Sabourin L.A. The Ste20-like kinase SLK is required for cell cycle progression through G2. J. Biol. Chem. 280 (2005) 42383-42390
28. Preston C.R., Flores C., and Engels W.R. Age-dependent usage of double-strand-break repair pathways. Curr. Biol. 16 (2006) 2009-2015
29. Riley T., Sontag E., Chen P., and Levine A. Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 9 (2008) 401-412
30. Rodríguez-Vilarrupla A., Diaz C., Canela N., Rahn H.P., Bachs O., and Agell N. Identification of the nuclear localization signal of p21(cip1) and consequences of its mutation on cell proliferation. FEBS Lett. 531 (2002) 319-323
31. Rooney S., Sekiguchi J., Whitlow S., Eckersdorff M., Manis J.P., Lee C., Ferguson D.O., and Alt F.W. Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 2410-2415
32. Rooney S., Sekiguchi J., Zhu C., Cheng H.L., Manis J., Whitlow S., DeVido J., Foy D., Chaudhuri J., Lombard D., and Alt F.W. Leaky Scid phenotype associated with defective V(D)J coding end processing in artemis-deficient mice. Mol. Cell 10 (2002) 1379-1390
33. Runge-Morris M.A. Sulfotransferase gene expression in rat hepatic and extrahepatic tissues. Chem. Biol. Interact. 92 (1994) 67-76
34. Saleh-Gohari N., Bryant H.E., Schultz N., Parker K.M., Cassel T.N., and Helleday T. Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol. Cell Biol. 25 (2005) 7158-7169
35. Salvi S.S., Nordenhall C., Blomberg A., Rudell B., Pourazar J., Kelly F.J., Wilson S., Sandstrom T., Holgate S.T., and Frew A.J. Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. Am. J. Respir. Crit. Care Med. 161 (2000) 550-557
36. Sedelnikova O.A., Horikawa I., Zimonjic D.B., Popescu N.C., Bonner W.M., and Barrett J.C. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 6 (2004) 168-170
37. Seluanov A., Mittelman D., Pereira-Smith O.M., Wilson J.H., and Gorbunova V. DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 7624-7629
38. Singh N.P., Ogburn C.E., Wolf N.S., van Belle G., and Martin G.M. DNA double-strand breaks in mouse kidney cells with age. Biogerontology 2 (2001) 261-270
39. Sonoda E., Sasaki M.S., Buerstedde J.M., Bezzubova O., Shinohara A., Ogawa H., Takata M., Yamaguchi-Iwai Y., and Tekeda S. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J. 17 (1998) 598-608
40. Tarloff J.B., Goldstein R.S., Sozio R.S., and Hook J.B. Hepatic and renal conjugation (Phase II) enzyme activities in young adult, middle-aged, and senescent male Sprague-Dawley rats. Proc. Soc. Exp. Biol. Med. 197 (1991) 297-303
41. Udell C.M., Lee S.K., and Davey S. HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene. Nucl. Acids Res. 26 (1998) 3971-3976
42. van Leeuwen F., Gafken P.R., and Gottschling D.E. Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell 109 (2002) 745-756
43. Vijg J., Dole M.E., Martus H.J., and Boerrigter M.E. Transgenic mouse models for studying mutations in vivo: applications in aging research. Mech. Ageing Dev. 98 (1997) 189-202
44. Walter C.A., Grabowski D.T., Street K.A., Conrad C.C., and Richardson A. Analysis and modulation of DNA repair in aging. Mech. Ageing Dev. 98 (1997) 203-222
45. Wang Q., Ponomareva O.N., Lasarev M., and Turker M.S. High frequency induction of mitotic recombination by ionizing radiation in Mlh1 null mouse cells. Mutat. Res. 594 (2006) 189-198
46. Warner H.R., and Price A.R. Involvement of DNA repair in cancer and aging. J. Gerontol. 44 (1989) 45-54
47. Wu Y., Kantake N., Sugiyama T., and Kowalczykowski S.C. Rad51 protein controls Rad52-mediated DNA annealing. J. Biol. Chem. 283 (2008) 14883-14892
48. Wysocki R., Javaheri A., Allard S., Sha F., Cote J., and Kron S.J. Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol. Cell Biol. 25 (2005) 8430-8443
49. Zhu W., Chen Y., and Dutta A. Rereplication by depletion of gemenin is seen regardless of p53 status and activates a G2/M checkpoint. Mol. Cell Biol. 24 (2004) 7140-7150
50. Zimmerman W.C., and Erikson R.L. Polo-like kinase 3 is required for entry into S phase. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 1847-1852