Involvement of Ku80 in microhomology-mediated end joining for DNA double-strand breaks in vivo

DNA Repair

Volumn 6, Issue 5, 2007, Pages 639-648

  Katsura, Yukitaka ^a,b   Sasaki, Shigeru ^a   Sato, Masanori ^a   Yamaoka, Kiyoshi ^c   Suzukawa, Kazumi ^b   Nagasawa, Toshiro ^b   Yokota, Jun ^a   Kohno, Takashi ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

DNA double strand breaks; Ku; Microhomology mediated end joining; Non homologous end joining

Indexed keywords

COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; KU ANTIGEN; KU80 PROTEIN; PLASMID DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CHO CELL; DNA REPAIR; DNA SEQUENCE; DNA STRAND BREAKAGE; GENETIC TRANSDUCTION; HUMAN; MAMMAL CELL; MATHEMATICAL MODEL; MICROHOMOLOGY MEDIATED END JOINING; MUTAGENESIS; NON HOMOLOGOUS END JOINING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROVIRUS;

ANIMALS; ANTIGENS, NUCLEAR; BASE SEQUENCE; CHO CELLS; CRICETINAE; CRICETULUS; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; RECOMBINATION, GENETIC; SEQUENCE HOMOLOGY, NUCLEIC ACID;

MAMMALIA;

EID: 34047169367     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2006.12.002     Document Type: Article

References (26)

1. Liang L., Deng L., Chen Y., Li G.C., Shao C., and Tischfield J.A. Modulation of DNA end joining by nuclear proteins. J. Biol. Chem. 280 (2005) 31442-31449
2. Ma J.L., Kim E.M., Haber J.E., and Lee S.E. Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences. Mol. Cell Biol. 23 (2003) 8820-8828
3. Betti C.J., Villalobos M.J., Diaz M.O., and Vaughan A.T. Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system. Cancer Res. 61 (2001) 4550-4555
4. Canning S., and Dryja T.P. Short, direct repeats at the breakpoints of deletions of the retinoblastoma gene. Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 5044-5048
5. Sasaki S., Kitagawa Y., Sekido Y., Minna J.D., Kuwano H., Yokota J., and Kohno T. Molecular processes of chromosome 9p21 deletions in human cancers. Oncogene 22 (2003) 3792-3798
6. Florl A.R., and Schulz W.A. Peculiar structure and location of 9p21 homozygous deletion breakpoints in human cancer cells. Genes Chromosomes Cancer 37 (2003) 141-148
7. Smanik P.A., Furminger T.L., Mazzaferri E.L., and Jhiang S.M. Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma. Hum. Mol. Genet. 4 (1995) 2313-2318
8. Jego N., Thomas G., and Hamelin R. Short direct repeats flanking deletions, and duplicating insertions in p53 gene in human cancers. Oncogene 8 (1993) 209-213
9. Iwao K., Nakamori S., Kameyama M., Imaoka S., Kinoshita M., Fukui T., Ishiguro S., Nakamura Y., and Miyoshi Y. Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations. Cancer Res. 58 (1998) 1021-1026
10. Kabotyanski E.B., Gomelsky L., Han J.O., Stamato T.D., and Roth D.B. Double-strand break repair in Ku86- and XRCC4-deficient cells. Nucleic Acids Res. 26 (1998) 5333-5342
11. Feldmann E., Schmiemann V., Goedecke W., Reichenberger S., and Pfeiffer P. DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining. Nucleic Acids Res. 28 (2000) 2585-2596
12. Verkaik N.S., Esveldt-van Lange R.E., van Heemst D., Bruggenwirth H.T., Hoeijmakers J.H., Zdzienicka M.Z., and van Gent D.C. Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur. J. Immunol. 32 (2002) 701-709
13. Smith J., Riballo E., Kysela B., Baldeyron C., Manolis K., Masson C., Lieber M.R., Papadopoulo D., and Jeggo P. Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res. 31 (2003) 2157-2167
14. Guirouilh-Barbat J., Huck S., Bertrand P., Pirzio L., Desmaze C., Sabatier L., and Lopez B.S. Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. Mol. Cell 14 (2004) 611-623
15. Khanna K.K., and Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nat. Genet. 27 (2001) 247-254
16. Valerie K., and Povirk L.F. Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22 (2003) 5792-5812
17. Lieber M.R., Ma Y., Pannicke U., and Schwarz K. Mechanism and regulation of human non-homologous DNA end-joining. Nat. Rev. Mol. Cell Biol. 4 (2003) 712-720
18. Budman J., and Chu G. Processing of DNA for nonhomologous end-joining by cell-free extract. EMBO J. 24 (2005) 849-860
19. Ma Y., Lu H., Tippin B., Goodman M.F., Shimazaki N., Koiwai O., Hsieh C.L., Schwarz K., and Lieber M.R. A biochemically defined system for mammalian nonhomologous DNA end joining. Mol. Cell 16 (2004) 701-713
20. Singleton B.K., Priestley A., Steingrimsdottir H., Gell D., Blunt T., Jackson S.P., Lehmann A.R., and Jeggo P.A. Molecular and biochemical characterization of xrs mutants defective in Ku80. Mol. Cell Biol. 17 (1997) 1264-1273
21. Sasaki S., Sato M., Katsura Y., Kurimasa A., Chen D.J., Takeda S., Kuwano H., Yokota J., and Kohno T. Rapid assessment of two major repair activities against DNA double-strand breaks in vertebrate cells. Biochem. Biophys. Res. Commun. 339 (2006) 583-590
22. Tauchi H., Kobayashi J., Morishima K., van Gent D.C., Shiraishi T., Verkaik N.S., vanHeems D., Ito E., Nakamura A., Sonoda E., Takata M., Takeda S., Matsuura S., and Komatsu K. Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells. Nature 420 (2002) 93-98
23. Liang F., and Jasin M. Ku80-deficient cells exhibit excess degradation of extrachromosomal DNA. J. Biol. Chem. 271 (1996) 14405-14411
24. Lieber M.R., Ma Y., Pannicke U., and Schwarz K. The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst.) 3 (2004) 817-826
25. Bartkova J., Horejsi Z., Koed K., Kramer A., Tort F., Zieger K., Guldberg P., Sehested M., Nesland J.M., Lukas C., Orntoft T., Lukas J., and Bartek J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434 (2005) 864-870
26. Gorgoulis V.G., Vassiliou L.V., Karakaidos P., Zacharatos P., Kotsinas A., Liloglou T., Venere M., Ditullio Jr. R.A., Kastrinakis N.G., Levy B., Kletsas D., Yoneta A., Herlyn M., Kittas C., and Halazonetis T.D. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434 (2005) 907-913