Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 18, 2009, Pages 6505-6511

  Micale, Nicola ^a   Ettari, Roberta ^a   Schirmeister, Tanja ^b   Evers, Astrid ^c   Gelhaus, Christoph ^c   Leippe, Matthias ^c   Zappalà, Maria ^a   Grasso, Silvana ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

2H Isoquinolin 3 ones; Cysteine proteases; Falcipain 2 inhibitors

Indexed keywords

2 AMINO 6,7 DIBENZYLOXY 1 (4 METHOXYPHENYL) 2H ISOQUINOLIN 3 ONE; ANTIMALARIAL AGENT; CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; FALCIPAIN 2; ISOQUINOLINE DERIVATIVE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTOZOAL PROTEIN; RHODESAIN; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA RHODESIENSE;

ANIMALS; ANTIPROTOZOAL AGENTS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; ISOQUINOLINES; MALARIA, FALCIPARUM; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI RHODESIENSE;

PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 69249147032     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.013     Document Type: Article

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