Novel peptidomimetics containing a Vinyl Ester moiety as highly potent and selective falcipain-2 inhibitors

Journal of Medicinal Chemistry

Volumn 52, Issue 7, 2009, Pages 2157-2160

  Ettari, Roberta ^a   Micale, Nicola ^a   Schirmeister, Tanja ^b   Gelhaus, Christoph ^c   Leippe, Matthias ^c   Nizi, Emanuela ^d   Di Francesco, Maria Emilia ^d   Grasso, Silvana ^a   Zappala, Maria ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF KIEL   (Germany)

^d IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CATHEPSIN; ESTER DERIVATIVE; FALCIPAIN 2; FALCIPAIN 2 INHIBITOR; KETONE DERIVATIVE; NITRILE; PEPTIDOMIMETIC AGENT; PROTEINASE INHIBITOR; QUINOXALINE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; BENZODIAZEPINES; CACO-2 CELLS; CATALYTIC DOMAIN; CATHEPSIN B; CATHEPSINS; CELL LINE; CELL MEMBRANE PERMEABILITY; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ESTERS; HUMANS; MICE; MOLECULAR MIMICRY; PEPTIDES; PLASMODIUM FALCIPARUM; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; VINYL COMPOUNDS;

EID: 64549114104     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900047j     Document Type: Article

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