Synthesis, chiral resolution, and enantiopharmacology of a potent 2,3-benzodiazepine derivative as noncompetitive AMPA receptor antagonist

Journal of Medicinal Chemistry

Volumn 49, Issue 2, 2006, Pages 575-581

  Zappalà, Maria ^a   Postorino, Giovanna ^a   Micale, Nicola ^a   Caccamese, Salvatore ^b   Parrinello, Nunziatina ^b   Grazioso, Giovanni ^c   Roda, Gabriella ^c   Menniti, Frank S ^d   De Sarro, Giovambattista ^e   Grasso, Silvana ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d PFIZER INC   (United States)

^e UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 AMINOPHENYL) 3,4 DIHYDRO 4 METHYL 3 METHYLCARBAMOYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 3,5 DIHYDRO 5 METHYL 7,8 METHYLENEDIOXY 4H 2,3 BENZODIAZEPIN 4 ONE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; BENZODIAZEPINE DERIVATIVE; CALCIUM ION; GYKI 53405; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TALAMPANEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; CEREBELLUM CORTEX; CHIRALITY; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; EPILEPSY; FEMALE; GRANULE CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

EID: 84962476695     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050552y     Document Type: Article

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