메뉴 건너뛰기




Volumn 12, Issue 9, 2009, Pages 566-575

Anti-amyloid antibody drugs in clinical testing for Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid; Clinical trial; Immunotherapy; MAb

Indexed keywords

ACC 001; AD 01; AD 02; ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; BAPINEUZUMAB; BAY 949172; BETABLOC; CAD 106; FLUORODEOXYGLUCOSE F 18; GAMMA SECRETASE INHIBITOR; GANTENERUMAB; GSK 933776A; IMMUNOGLOBULIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; LY 2062430; MABT 5102A; MONOCLONAL ANTIBODY; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE; PF 04360365; PF 4360365; R 1450; SEMAGACESTAT; SOLANEZUMAB; UNCLASSIFIED DRUG; V 950;

EID: 69249127474     PISSN: 13697056     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (81)
  • 2
    • 0025753852 scopus 로고    scopus 로고
    • Selkoe DJ: The molecular pathology of Alzheimer's disease. Neuron (1991) 6(4):487-498.**Seminal paper to posit the amyloid hypothesis, drawing significantly from genetic studies to support this hypothesis.
    • Selkoe DJ: The molecular pathology of Alzheimer's disease. Neuron (1991) 6(4):487-498.**Seminal paper to posit the amyloid hypothesis, drawing significantly from genetic studies to support this hypothesis.
  • 3
    • 0028123071 scopus 로고
    • Alzheimer's disease: A central role for amyloid
    • Selkoe DJ: Alzheimer's disease: A central role for amyloid. J Neuropathol Exp Neurol (1994) 53(5):438-447.
    • (1994) J Neuropathol Exp Neurol , vol.53 , Issue.5 , pp. 438-447
    • Selkoe, D.J.1
  • 4
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science (2002) 297(5580):353-356.
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 5
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy JA, Higgins GA: Alzheimer's disease: The amyloid cascade hypothesis. Science (1992) 256(5054):184-185.
    • (1992) Science , vol.256 , Issue.5054 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 8
    • 0031003233 scopus 로고    scopus 로고
    • The Alzheimer family of diseases: Many etiologies, one pathogenesis?
    • Hardy J: The Alzheimer family of diseases: Many etiologies, one pathogenesis? Proc Natl Acad Sci USA (1997) 94(6):2095-2097.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.6 , pp. 2095-2097
    • Hardy, J.1
  • 9
    • 8644240928 scopus 로고    scopus 로고
    • Vascular pathologies and cognition in a population-based cohort of elderly people
    • Fernando MS, Ince PG: Vascular pathologies and cognition in a population-based cohort of elderly people. J Neurol Sci (2004) 226(1-2):13-17.
    • (2004) J Neurol Sci , vol.226 , Issue.1-2 , pp. 13-17
    • Fernando, M.S.1    Ince, P.G.2
  • 11
    • 66049148147 scopus 로고    scopus 로고
    • Biological CSF markers of Alzheimer's disease
    • Zetterberg H, Blennow K: Biological CSF markers of Alzheimer's disease. Handb Clin Neurol (2008) 89:261-268.
    • (2008) Handb Clin Neurol , vol.89 , pp. 261-268
    • Zetterberg, H.1    Blennow, K.2
  • 15
    • 33644832047 scopus 로고    scopus 로고
    • 42 levels in the CSF.
    • 42 levels in the CSF.
  • 16
    • 56749112290 scopus 로고    scopus 로고
    • The future of amyloid-β imaging: A tale of radionuclides and tracer proliferation
    • Klunk WE, Mathis CA: The future of amyloid-β imaging: A tale of radionuclides and tracer proliferation. Curr Opin Neurol (2008) 21(6):683-687.
    • (2008) Curr Opin Neurol , vol.21 , Issue.6 , pp. 683-687
    • Klunk, W.E.1    Mathis, C.A.2
  • 18
    • 34447326955 scopus 로고    scopus 로고
    • Amyloid imaging in Alzheimer's disease
    • Nordberg A: Amyloid imaging in Alzheimer's disease. Curr Opin Neurol (2007) 20(4):398-402.
    • (2007) Curr Opin Neurol , vol.20 , Issue.4 , pp. 398-402
    • Nordberg, A.1
  • 20
    • 47949132196 scopus 로고    scopus 로고
    • Active and passive immunotherapy for neurodegenerative disorders
    • Brody DL, Holtzman DM: Active and passive immunotherapy for neurodegenerative disorders. Annu Rev Neurosci (2008) 31:175-193.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 175-193
    • Brody, D.L.1    Holtzman, D.M.2
  • 21
    • 33646384419 scopus 로고    scopus 로고
    • Immunology and immunotherapy of Alzheimer's disease
    • Weiner HL, Frenkel D: Immunology and immunotherapy of Alzheimer's disease. Nat Rev Immunol (2006) 6(5):404-416.
    • (2006) Nat Rev Immunol , vol.6 , Issue.5 , pp. 404-416
    • Weiner, H.L.1    Frenkel, D.2
  • 22
    • 70349123872 scopus 로고    scopus 로고
    • O3-05-02: EHT-0202: A neuroprotective and procognitive α-secretase stimulator targeted towards Alzheimer disease therapy
    • Abs O3-05-02
    • Desire L, Buee L, Lambeng N, Drouin D, Schweighoffer F: O3-05-02: EHT-0202: A neuroprotective and procognitive α-secretase stimulator targeted towards Alzheimer disease therapy. Alzheimer's and Dementia (2008) 4(4 Suppl 1):Abs O3-05-02.
    • (2008) Alzheimer's and Dementia , vol.4 , Issue.4 SUPPL. 1
    • Desire, L.1    Buee, L.2    Lambeng, N.3    Drouin, D.4    Schweighoffer, F.5
  • 24
    • 20944448555 scopus 로고    scopus 로고
    • Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, Fox NC, Eisner L, Kirby L, Rovira MB, Forette F, Orgogozo JM: Clinical effects of β immunization (AN1792) in patients with AD in an interrupted trial. Neurology (2005) 64(9):1553-1562. * First paper to comprehensively describe the overall clinical outcome in patients with AD, who received from one to three administrations of AN-1792 (n = 300) or placebo (n = 72) and were followed for a minimum of 9 months after the last injection.
    • Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, Fox NC, Eisner L, Kirby L, Rovira MB, Forette F, Orgogozo JM: Clinical effects of β immunization (AN1792) in patients with AD in an interrupted trial. Neurology (2005) 64(9):1553-1562. * First paper to comprehensively describe the overall clinical outcome in patients with AD, who received from one to three administrations of AN-1792 (n = 300) or placebo (n = 72) and were followed for a minimum of 9 months after the last injection.
  • 25
    • 67650409845 scopus 로고    scopus 로고
    • S2-04-06: Safety, tolerability and immunogenicity of the Aβ immunotherapeutic vaccine CAD106 in a first-in-man study in Alzheimer patients
    • Abs S2-04-06
    • Winblad B: S2-04-06: Safety, tolerability and immunogenicity of the Aβ immunotherapeutic vaccine CAD106 in a first-in-man study in Alzheimer patients. Alzheimer;s and Dementia (2008) 4(4 Suppl 1):Abs S2-04-06.
    • (2008) Alzheimer;s and Dementia , vol.4 , Issue.4 SUPPL. 1
    • Winblad, B.1
  • 26
    • 69249125588 scopus 로고    scopus 로고
    • Annual Report , March 14
    • Wyeth: Annual report 2001. Annual Report (2002): March 14.
    • (2002) Annual report 2001
    • Wyeth1
  • 27
    • 46749113799 scopus 로고    scopus 로고
    • Targeting β-amyloid pathology in Alzheimer's disease with Aβ immunotherapy
    • Nitsch RM, Hock C: Targeting β-amyloid pathology in Alzheimer's disease with Aβ immunotherapy. Neurotherapeutics (2008) 5(3):415-420.
    • (2008) Neurotherapeutics , vol.5 , Issue.3 , pp. 415-420
    • Nitsch, R.M.1    Hock, C.2
  • 28
    • 0035123370 scopus 로고    scopus 로고
    • The functions of the amyloid precursor protein gene
    • Panegyres PK: The functions of the amyloid precursor protein gene. Rev Neurosci (2001) 12(1):1-39.
    • (2001) Rev Neurosci , vol.12 , Issue.1 , pp. 1-39
    • Panegyres, P.K.1
  • 29
    • 69249138938 scopus 로고    scopus 로고
    • Passive immunotherapies as an approach to disease modification in Alzheimer's disease
    • Chicago, IL, USA
    • Morgan D: Passive immunotherapies as an approach to disease modification in Alzheimer's disease. Satellite Symposium International Conference on Alzheimer's Disease, Chicago, IL, USA (2008).
    • (2008) Satellite Symposium International Conference on Alzheimer's Disease
    • Morgan, D.1
  • 30
    • 33745111586 scopus 로고    scopus 로고
    • Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice
    • Carty NC, Wilcock DM, Rosenthal A, Grimm J, Pons J, Ronan V, Gottschall PE, Gordon MN, Morgan D: Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice. J Neuroinflammation (2006) 3:11.
    • (2006) J Neuroinflammation , vol.3 , pp. 11
    • Carty, N.C.1    Wilcock, D.M.2    Rosenthal, A.3    Grimm, J.4    Pons, J.5    Ronan, V.6    Gottschall, P.E.7    Gordon, M.N.8    Morgan, D.9
  • 31
    • 33745001453 scopus 로고    scopus 로고
    • Deglycosylated anti-amyloid-β antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice
    • Wilcock DM, Alamed J, Gottschall PE, Grimm J, Rosenthal A, Pons J, Ronan V, Symmonds K, Gordon MN, Morgan D: Deglycosylated anti-amyloid-β antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. J Neurosci (2006) 26(20):5340-5346.
    • (2006) J Neurosci , vol.26 , Issue.20 , pp. 5340-5346
    • Wilcock, D.M.1    Alamed, J.2    Gottschall, P.E.3    Grimm, J.4    Rosenthal, A.5    Pons, J.6    Ronan, V.7    Symmonds, K.8    Gordon, M.N.9    Morgan, D.10
  • 32
    • 69249112464 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of the anti-amyloid monoclonal antibody PF-04360365 following a single infusion in patients with mild-to-moderate Alzheimer's Disease: Preliminary results
    • Bednar MM, Zhao Q, Landen JW, Billing CB, Rohrbacher K, Kupiec JW: Safety and pharmacokinetics of the anti-amyloid monoclonal antibody PF-04360365 following a single infusion in patients with mild-to-moderate Alzheimer's Disease: Preliminary results. Alzheimer Dementia (2009) 5(4):P157.
    • (2009) Alzheimer Dementia , vol.5 , Issue.4
    • Bednar, M.M.1    Zhao, Q.2    Landen, J.W.3    Billing, C.B.4    Rohrbacher, K.5    Kupiec, J.W.6
  • 34
    • 60549107033 scopus 로고    scopus 로고
    • A specific enzyme-linked immunosorbent assay for measuring β-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease
    • Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ: A specific enzyme-linked immunosorbent assay for measuring β-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch Neurol (2009) 66(2):190-199.
    • (2009) Arch Neurol , vol.66 , Issue.2 , pp. 190-199
    • Xia, W.1    Yang, T.2    Shankar, G.3    Smith, I.M.4    Shen, Y.5    Walsh, D.M.6    Selkoe, D.J.7
  • 36
    • 60549094292 scopus 로고    scopus 로고
    • P2-393: Increasing the efficacy of immunotherapy for Alzheimer's disease (AD) with intravenous immunoglobulin (IVIG)
    • Abs P2-393
    • Szabo P, Esteban M, Monthe C, White L, Lent R, Relkin N, Weksler M: P2-393: Increasing the efficacy of immunotherapy for Alzheimer's disease (AD) with intravenous immunoglobulin (IVIG). Alzheimer's and Dementia (2006) 2(3 Suppl 1):Abs P2-393.
    • (2006) Alzheimer's and Dementia , vol.2 , Issue.3 SUPPL. 1
    • Szabo, P.1    Esteban, M.2    Monthe, C.3    White, L.4    Lent, R.5    Relkin, N.6    Weksler, M.7
  • 37
    • 33846080463 scopus 로고    scopus 로고
    • Drug insight: The use of intravenous immunoglobulin in neurology Therapeutic considerations and practical issues
    • Gold R, Stangel M, Dalakas MC: Drug insight: The use of intravenous immunoglobulin in neurology Therapeutic considerations and practical issues. Nat Clin Pract Neurol (2007) 3(1):36-44.
    • (2007) Nat Clin Pract Neurol , vol.3 , Issue.1 , pp. 36-44
    • Gold, R.1    Stangel, M.2    Dalakas, M.C.3
  • 38
    • 19944431509 scopus 로고    scopus 로고
    • Exacerbation of cerebral amyloid angiopathyassociated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid β
    • Racke MM, Boone LI, Hepburn DL, Parsadainian M, Bryan MT, Ness DK, Piroozi KS, Jordan WH, Brown DD, Hoffman WP, Holtzman DM et al: Exacerbation of cerebral amyloid angiopathyassociated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid β. J Neurosci (2005) 25(3):629-636.
    • (2005) J Neurosci , vol.25 , Issue.3 , pp. 629-636
    • Racke, M.M.1    Boone, L.I.2    Hepburn, D.L.3    Parsadainian, M.4    Bryan, M.T.5    Ness, D.K.6    Piroozi, K.S.7    Jordan, W.H.8    Brown, D.D.9    Hoffman, W.P.10    Holtzman, D.M.11
  • 40
    • 76849117025 scopus 로고    scopus 로고
    • S1-02-02: Natural human antibodies targeting amyloid aggregates in intravenous immunoglobulin
    • Abs S1-02-02
    • Relkin NR: S1-02-02: Natural human antibodies targeting amyloid aggregates in intravenous immunoglobulin. Alzheimer's and Dementia (2008) 4(4 Suppl 1):Abs S1-02-02.
    • (2008) Alzheimer's and Dementia , vol.4 , Issue.4 SUPPL. 1
    • Relkin, N.R.1
  • 41
    • 0035979145 scopus 로고    scopus 로고
    • Aβ immunization: Moving Aβ peptide from brain to blood
    • Lee VMY: Aβ immunization: Moving Aβ peptide from brain to blood. Proc Natl Acad Sci USA (2001) 98(16):8931-8932.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.16 , pp. 8931-8932
    • Lee, V.M.Y.1
  • 42
    • 0035902619 scopus 로고    scopus 로고
    • DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM: Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA (2001) 98(15):8850-8855. ** Studying PDAPP (PDGF promoter expressing APP) transgenic mice, a rise in Aβ levels in the plasma of > 1000-fold was observed after the peripheral administration of a mAb targeting amyloid. This rise in Aβ was due, in part, to the peripheral effects of the mAb that altered the clearance of amyloid from the CNS.
    • DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM: Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA (2001) 98(15):8850-8855. ** Studying PDAPP (PDGF promoter expressing APP) transgenic mice, a rise in Aβ levels in the plasma of > 1000-fold was observed after the peripheral administration of a mAb targeting amyloid. This rise in Aβ was due, in part, to the peripheral effects of the mAb that altered the clearance of amyloid from the CNS.
  • 43
    • 52649157170 scopus 로고    scopus 로고
    • Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid β-protein in perivascular astrocytes
    • Utter S, Tamboli IY, Walter J, Upadhaya AR, Birkenmeier G, Pietrzik CU, Ghebremedhin E, Thal DR: Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid β-protein in perivascular astrocytes. J Neuropathol Exp Neurol (2008) 67(9):842-856.
    • (2008) J Neuropathol Exp Neurol , vol.67 , Issue.9 , pp. 842-856
    • Utter, S.1    Tamboli, I.Y.2    Walter, J.3    Upadhaya, A.R.4    Birkenmeier, G.5    Pietrzik, C.U.6    Ghebremedhin, E.7    Thal, D.R.8
  • 44
    • 34249040510 scopus 로고    scopus 로고
    • Blood-brain barrier impairment in Alzheimer disease: Stability and functional significance
    • Bowman GL, Kaye JA, Moore M, Waichunas D, Carlson NE, Quinn JF: Blood-brain barrier impairment in Alzheimer disease: Stability and functional significance. Neurology (2007) 68(21):1809-1814.
    • (2007) Neurology , vol.68 , Issue.21 , pp. 1809-1814
    • Bowman, G.L.1    Kaye, J.A.2    Moore, M.3    Waichunas, D.4    Carlson, N.E.5    Quinn, J.F.6
  • 45
    • 33750874717 scopus 로고    scopus 로고
    • Vaccine development for Alzheimer's disease
    • DaSilva KA, Aubert I, McLaurin JA: Vaccine development for Alzheimer's disease. Curr Pharm Des (2006) 12(33):4283-4293.
    • (2006) Curr Pharm Des , vol.12 , Issue.33 , pp. 4283-4293
    • DaSilva, K.A.1    Aubert, I.2    McLaurin, J.A.3
  • 48
    • 47149112621 scopus 로고    scopus 로고
    • 42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial. Lancet (2008) 372(9634):216-223. * A thought-provoking paper on the cognitive-histopathological relationship of a group of patients immunized with AN-1793 who were followed until death; results of the post-mortem autopsy were also analyzed.
    • 42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial. Lancet (2008) 372(9634):216-223. * A thought-provoking paper on the cognitive-histopathological relationship of a group of patients immunized with AN-1793 who were followed until death; results of the post-mortem autopsy were also analyzed.
  • 49
    • 0036240395 scopus 로고    scopus 로고
    • Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, Paul SM: Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model. Nat Neurosci (2002) 5(5):452-457. * Provides evidence that the reversal of memory deficits in transgenic mice may be affected by alterations in soluble amyloid rather than insoluble brain amyloid.
    • Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, Paul SM: Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model. Nat Neurosci (2002) 5(5):452-457. * Provides evidence that the reversal of memory deficits in transgenic mice may be affected by alterations in soluble amyloid rather than insoluble brain amyloid.
  • 51
    • 65249163018 scopus 로고    scopus 로고
    • O3-04-05: Clinical trials of bapineuzumab, a β-amyloid-targeted immunotherapy in patients with mild to moderate Alzheimer's disease
    • Abs O3-04-05
    • Grundman M, Black R: O3-04-05: Clinical trials of bapineuzumab, a β-amyloid-targeted immunotherapy in patients with mild to moderate Alzheimer's disease. Alzheimer's and Dementia (2008) 4(4 Suppl 1):Abs O3-04-05.
    • (2008) Alzheimer's and Dementia , vol.4 , Issue.4 SUPPL. 1
    • Grundman, M.1    Black, R.2
  • 52
    • 1542268242 scopus 로고    scopus 로고
    • Bennett DA, Schneider JA, Wilson RS, Bienias JL, Arnold SE: Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch Neurol (2004) 61(3):378-384. * Human cognitive-neuropathological correlation from the Religious Orders Study, which provided evidence that tau may be the downstream mediator for the cognitive decline previously associated with the more proximal event of amyloid deposition.
    • Bennett DA, Schneider JA, Wilson RS, Bienias JL, Arnold SE: Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch Neurol (2004) 61(3):378-384. * Human cognitive-neuropathological correlation from the Religious Orders Study, which provided evidence that tau may be the downstream mediator for the cognitive decline previously associated with the more proximal event of amyloid deposition.
  • 55
    • 70049083865 scopus 로고    scopus 로고
    • Relkin NR, Szabo P, Adamiak B, Burgut T, Monthe C, Lent RW, Younkin S, Younkin L, Schiff R, Weksler ME: 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol Aging (2008):doi:10.1016/j.neurobiolaging.2007.12.021 * Despite a small patient population (n = 8), this study demonstrates an association of cognitive improvement/stabilization with changes in Aβ levels in the plasma and CSF during IVIg administration, with reversion to baseline during a 3-month withdrawal period that occurred between a 6-month and a 9-month IVIg dosing period.
    • Relkin NR, Szabo P, Adamiak B, Burgut T, Monthe C, Lent RW, Younkin S, Younkin L, Schiff R, Weksler ME: 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol Aging (2008):doi:10.1016/j.neurobiolaging.2007.12.021 * Despite a small patient population (n = 8), this study demonstrates an association of cognitive improvement/stabilization with changes in Aβ levels in the plasma and CSF during IVIg administration, with reversion to baseline during a 3-month withdrawal period that occurred between a 6-month and a 9-month IVIg dosing period.
  • 56
    • 69249149090 scopus 로고    scopus 로고
    • Cognitive and functional outcomes from a phase II trial of bapineuzumab in mild to moderate Alzheimer's disease
    • WA, USA ():Abs
    • Salloway S SR, Gregg K, Black R, Grundman M: Cognitive and functional outcomes from a phase II trial of bapineuzumab in mild to moderate Alzheimer's disease. American Academy of Neurology, Seattle, WA, USA (2009):Abs S32.002.
    • (2009) American Academy of Neurology, Seattle
    • Salloway, S.S.1    Gregg, K.2    Black, R.3    Grundman, M.4
  • 58
    • 69249150272 scopus 로고    scopus 로고
    • O3-05-04: Intravenous immunoglobulin (IVIg) maintains cognition over 18 months in patients with Alzheimer's disease (AD)
    • Abs O3-05-04
    • Adamiak B, Monthe C, Bender H, Szabo P, Schiff R, Weksler ME, Relkin NR: O3-05-04: Intravenous immunoglobulin (IVIg) maintains cognition over 18 months in patients with Alzheimer's disease (AD). Alzheimer's and Dementia (2006) 2(3 Suppl 1):Abs O3-05-04.
    • (2006) Alzheimer's and Dementia , vol.2 , Issue.3 SUPPL. 1
    • Adamiak, B.1    Monthe, C.2    Bender, H.3    Szabo, P.4    Schiff, R.5    Weksler, M.E.6    Relkin, N.R.7
  • 59
    • 69249142076 scopus 로고    scopus 로고
    • A multicentre, randomised, double blind, placebo controlled, multiple ascending dose, safety, tolerability, and amyloidimaging positron emission tomography (PET) trial of AAB 001 (ELN115727) in patients with mild to moderate Alzheimer's disease (AD): Current Controlled Trials Ltd, London, UK (2009). controlled-trials.com/ISRCTN17517446
    • A multicentre, randomised, double blind, placebo controlled, multiple ascending dose, safety, tolerability, and amyloidimaging positron emission tomography (PET) trial of AAB 001 (ELN115727) in patients with mild to moderate Alzheimer's disease (AD): Current Controlled Trials Ltd, London, UK (2009). controlled-trials.com/ISRCTN17517446
  • 60
    • 18144415471 scopus 로고    scopus 로고
    • Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    • Fox NC, Black RS, Gilman S, Rossor MN, Griffith SG, Jenkins L, Koller M: Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease. Neurology (2005) 64(9):1563-1572.
    • (2005) Neurology , vol.64 , Issue.9 , pp. 1563-1572
    • Fox, N.C.1    Black, R.S.2    Gilman, S.3    Rossor, M.N.4    Griffith, S.G.5    Jenkins, L.6    Koller, M.7
  • 61
    • 69249120453 scopus 로고    scopus 로고
    • Effect of bapineuzumab on MRI measures of cerebral volume change in patients with Alzheimer's disease
    • WA, USA ():Abs
    • Fox NC, DeCarli C, Black R, Grundman M: Effect of bapineuzumab on MRI measures of cerebral volume change in patients with Alzheimer's disease. American Academy of Neurology, Seattle, WA, USA (2009):Abs P03.098.
    • (2009) American Academy of Neurology, Seattle
    • Fox, N.C.1    DeCarli, C.2    Black, R.3    Grundman, M.4
  • 63
    • 70349847734 scopus 로고    scopus 로고
    • Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances
    • doi:10.1016/j.neurobiolaging.2008.01.017
    • Thal DR, Capetillo-Zarate E, Larionov S, Staufenbiel M, Zurbruegg S, Beckmann N: Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances. Neurobiol Aging (2008):doi:10.1016/j.neurobiolaging.2008.01.017.
    • (2008) Neurobiol Aging
    • Thal, D.R.1    Capetillo-Zarate, E.2    Larionov, S.3    Staufenbiel, M.4    Zurbruegg, S.5    Beckmann, N.6
  • 64
    • 51349166667 scopus 로고    scopus 로고
    • 2O PET imaging, respectively, and were demonstrated to be inversely correlated in various (though not all) brain regions.
    • 2O PET imaging, respectively, and were demonstrated to be inversely correlated in various (though not all) brain regions.
  • 65
    • 0037703255 scopus 로고    scopus 로고
    • Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H et al: RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat Med (2003) 9(7):907-913. * Describes the interaction of Aβ with the receptor for advanced glycation endproducts (RAGE) at the BBB in transgenic mice, resulting in the transport of Aβ into the CNS and an associated proinflammatory response, thus outlining a possible target for modulating AD pathology.
    • Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H et al: RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat Med (2003) 9(7):907-913. * Describes the interaction of Aβ with the receptor for advanced glycation endproducts (RAGE) at the BBB in transgenic mice, resulting in the transport of Aβ into the CNS and an associated proinflammatory response, thus outlining a possible target for modulating AD pathology.
  • 67
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • Farkas E, Luiten PG: Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol (2001) 64(6):575-611.
    • (2001) Prog Neurobiol , vol.64 , Issue.6 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.2
  • 68
    • 33748925716 scopus 로고    scopus 로고
    • Interventions for heart disease and their effects on Alzheimer's disease
    • Wolozin B, Bednar MM: Interventions for heart disease and their effects on Alzheimer's disease. Neurol Res (2006) 28(6): 630-636.
    • (2006) Neurol Res , vol.28 , Issue.6 , pp. 630-636
    • Wolozin, B.1    Bednar, M.M.2
  • 70
    • 54349124928 scopus 로고    scopus 로고
    • O4-03-04: Safety assessments and biomarker changes following a monoclonal Aβ antibody given to subjects with Alzheimer's disease
    • Abs O4-03-04
    • Siemers ER, Benson C, Gonzales C, Hansen R, Dean RA, Farlow MR, DeMattos R: O4-03-04: Safety assessments and biomarker changes following a monoclonal Aβ antibody given to subjects with Alzheimer's disease. Alzheimer's and Dementia (2006) 2(3 Suppl 1):Abs O4-03-04.
    • (2006) Alzheimer's and Dementia , vol.2 , Issue.3 SUPPL. 1
    • Siemers, E.R.1    Benson, C.2    Gonzales, C.3    Hansen, R.4    Dean, R.A.5    Farlow, M.R.6    DeMattos, R.7
  • 71
    • 48949085739 scopus 로고    scopus 로고
    • Amyloid-β immunisation for Alzheimer's disease
    • Wisniewski T, Konietzko U: Amyloid-β immunisation for Alzheimer's disease. Lancet Neurol (2008) 7(9):805-811.
    • (2008) Lancet Neurol , vol.7 , Issue.9 , pp. 805-811
    • Wisniewski, T.1    Konietzko, U.2
  • 72
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K et al: Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med (2000) 6(8): 916-919.
    • (2000) Nat Med , vol.6 , Issue.8 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3    Burke, R.L.4    Games, D.5    Grajeda, H.6    Guido, T.7    Hu, K.8    Huang, J.9    Johnson-Wood, K.10    Khan, K.11
  • 74
    • 0035877075 scopus 로고    scopus 로고
    • Antibody-mediated phagocytosis of the amyloid β-peptide in microglia is differentially modulated by C1q
    • Webster SD, Galvan MD, Ferran E, Garzon-Rodriguez W, Glabe CG, Tenner AJ: Antibody-mediated phagocytosis of the amyloid β-peptide in microglia is differentially modulated by C1q. J Immunol (2001) 166(12):7496-7503.
    • (2001) J Immunol , vol.166 , Issue.12 , pp. 7496-7503
    • Webster, S.D.1    Galvan, M.D.2    Ferran, E.3    Garzon-Rodriguez, W.4    Glabe, C.G.5    Tenner, A.J.6
  • 76
    • 47949132196 scopus 로고    scopus 로고
    • Active and passive immunotherapy for neurodegenerative disorders
    • Brody DL, Holtzman DM: Active and passive immunotherapy for neurodegenerative disorders. Annu Rev Neurosci (2008) 31:175-193.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 175-193
    • Brody, D.L.1    Holtzman, D.M.2
  • 77
    • 30844472909 scopus 로고    scopus 로고
    • IgG-assisted age-dependent clearance of Alzheimer's amyloid β peptide by the blood-brain barrier neonatal Fc receptor
    • Describes neonatal Fc receptor-mediated transport of amyloid across the BBB; details of this process are relevant to understanding the equilibrium established for amyloid between central and peripheral compartments, *
    • Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV: IgG-assisted age-dependent clearance of Alzheimer's amyloid β peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci (2005) 25(50):11495-11503. * Describes neonatal Fc receptor-mediated transport of amyloid across the BBB; details of this process are relevant to understanding the equilibrium established for amyloid between central and peripheral compartments.
    • (2005) J Neurosci , vol.25 , Issue.50 , pp. 11495-11503
    • Deane, R.1    Sagare, A.2    Hamm, K.3    Parisi, M.4    LaRue, B.5    Guo, H.6    Wu, Z.7    Holtzman, D.M.8    Zlokovic, B.V.9
  • 78
    • 4043167747 scopus 로고    scopus 로고
    • Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM: Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron (2004) 43(3):321-332.
    • (2004) Neuron , vol.43 , Issue.3 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    LaFerla, F.M.5
  • 79
    • 69249123594 scopus 로고    scopus 로고
    • Weller RO: CSF, interstitial fluid, cerebrovascular disease and Alzheimer's disease. The 4th International Congress of the International Society for Vascular Behavioral and Cognitive Disorders (VAS-COG), City of Singapore, Singapore (2009).
    • Weller RO: CSF, interstitial fluid, cerebrovascular disease and Alzheimer's disease. The 4th International Congress of the International Society for Vascular Behavioral and Cognitive Disorders (VAS-COG), City of Singapore, Singapore (2009).
  • 81
    • 67649268898 scopus 로고    scopus 로고
    • P4-351: Effects of uninterrrupted intravenous immunoglobulin treatment of Alzheimer's disease for nine months
    • Abs P4-351
    • Tsakanikas D, Shah K, Flores C, Assuras S, Relkin NR: P4-351: Effects of uninterrrupted intravenous immunoglobulin treatment of Alzheimer's disease for nine months. Alzheimer's and Dementia (2008) 4(4 Suppl 1):Abs P4-351.
    • (2008) Alzheimer's and Dementia , vol.4 , Issue.4 SUPPL. 1
    • Tsakanikas, D.1    Shah, K.2    Flores, C.3    Assuras, S.4    Relkin, N.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.