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Volumn 29, Issue 15, 2009, Pages 4964-4971

Suppression of amyloid deposition leads to long-term reductions in alzheimer's pathologies in Tg2576 mice

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ANTIBODY; PROTEIN; DROSOPHILA PROTEIN;

EID: 65549113533     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4560-08.2009     Document Type: Article
Times cited : (31)

References (32)
  • 1
    • 34248659126 scopus 로고    scopus 로고
    • Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice
    • DOI 10.1038/nprot.2006.275, PII NPROT.2006.275
    • Alamed J, Wilcock DM, Diamond DM, Gordon MN, Morgan D (2006) Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice. Nat Protoc 1:1671-1679. (Pubitemid 46773288)
    • (2006) Nature Protocols , vol.1 , Issue.4 , pp. 1671-1679
    • Alamed, J.1    Wilcock, D.M.2    Diamond, D.M.3    Gordon, M.N.4    Morgan, D.5
  • 3
    • 13644266898 scopus 로고    scopus 로고
    • Age- and region-dependent alterations in A-degrading enzymes: Implications for A-induced disorders
    • DOI 10.1016/j.neurobiolaging.2004.06.013
    • Caccamo A, Oddo S, Sugarman MC, Akbari Y, LaFerla FM (2005) Age-and region-dependent alterations in Abeta-degrading enzymes: Implications for Abeta-induced disorders. Neurobiol Aging 26:645-654. (Pubitemid 40228756)
    • (2005) Neurobiology of Aging , vol.26 , Issue.5 , pp. 645-654
    • Caccamo, A.1    Oddo, S.2    Sugarman, M.C.3    Akbari, Y.4    LaFerla, F.M.5
  • 4
    • 9644305699 scopus 로고    scopus 로고
    • Effect of age on the duration and extent of amyloid plaque reduction and microglial activation after injection of anti-A antibody into the third ventricle of TgCRND8 mice
    • DOI 10.1002/jnr.20298
    • Chauhan NB, Siegel GJ, Lichtor T (2004) Effect of age on the duration and extent of amyloid plaque reduction and microglial activation after injection of anti-Abeta antibody into the third ventricle of TgCRNDS mice. J Neurosci Res 78:732-741. (Pubitemid 39657590)
    • (2004) Journal of Neuroscience Research , vol.78 , Issue.5 , pp. 732-741
    • Chauhan, N.B.1    Siegel, G.J.2    Lichtor, T.3
  • 6
    • 0034746897 scopus 로고    scopus 로고
    • Reduced effectiveness of A1-42 immunization in APP transgenic mice with significant amyloid deposition
    • DOI 10.1016/S0197-4580(01)00245-7, PII S0197458001002457
    • Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE (2001) Reduced effectiveness of Abetal-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiol Aging 22:721-727. (Pubitemid 33055611)
    • (2001) Neurobiology of Aging , vol.22 , Issue.5 , pp. 721-727
    • Das, P.1    Murphy, M.P.2    Younkin, L.H.3    Younkin, S.G.4    Golde, T.E.5
  • 10
    • 5044222305 scopus 로고    scopus 로고
    • Time-dependent reduction in A levels after intracranial LPS administration in APP transgenic mice
    • DOI 10.1016/j.expneurol.2004.07.007, PII S0014488604002924
    • Herber DL, Roth LM, Wilson D, Wilson N, Mason JE, Morgan D, Gordon MN (2004) Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice. Exp Neurol 190:245-253. (Pubitemid 39335723)
    • (2004) Experimental Neurology , vol.190 , Issue.1 , pp. 245-253
    • Herber, D.L.1    Roth, L.M.2    Wilson, D.3    Wilson, N.4    Mason, J.E.5    Morgan, D.6    Gordon, M.N.7
  • 13
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, A elevation, and amyloid plaques in transgenic mice
    • DOI 10.1126/science.274.5284.99
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99-102. (Pubitemid 26332733)
    • (1996) Science , vol.274 , Issue.5284 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 14
    • 0037010286 scopus 로고    scopus 로고
    • Region-specific reduction of A-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging
    • DOI 10.1002/jnr.10390
    • Iwata N, Takaki Y, Fukami S, Tsubuki S, Saido TC (2002) Region-specific reduction of A beta-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. J Neurosci Res 70:493-500. (Pubitemid 35222386)
    • (2002) Journal of Neuroscience Research , vol.70 , Issue.3 , pp. 493-500
    • Iwata, N.1    Takaki, Y.2    Fukami, S.3    Tsubuki, S.4    Saido, T.C.5
  • 15
    • 0028169925 scopus 로고
    • Visualization of Abeta42(43) and Abeta40 in senile plaques with end-specific Abeta monoclonals: Evidence that an initially deposited species is Abeta42(43)
    • DOI 10.1016/0896-6273(94)90458-8
    • Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y (1994) Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: Evidence that an initially deposited species is Abeta 42(43). Neuron 13:45-53. (Pubitemid 2122600)
    • (1994) Neuron , vol.13 , Issue.1 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 17
    • 0027195933 scopus 로고
    • Seeding 'one-dimensional crystallization' of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
    • DOI 10.1016/0092-8674(93)90635-4
    • Jarrett JT, Lansbury PT Jr (1993) Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie? Cell 73:1055-1058. (Pubitemid 23180480)
    • (1993) Cell , vol.73 , Issue.6 , pp. 1055-1058
    • Jarrett, J.T.1    Lansbury Jr., P.T.2
  • 18
    • 0027258525 scopus 로고
    • The carboxy terminus of the amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
    • DOI 10.1021/bi00069a001
    • Jarrett JT, Berger EP, Lansbury PT Jr (1993) The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease. Biochemistry 32:4693-4697. (Pubitemid 23162022)
    • (1993) Biochemistry , vol.32 , Issue.18 , pp. 4693-4697
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury Jr., P.T.3
  • 20
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG (2001) Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21:372-381. (Pubitemid 32107428)
    • (2001) Journal of Neuroscience , vol.21 , Issue.2 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 22
  • 23
    • 33751111439 scopus 로고    scopus 로고
    • Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid β40, and amyloid β42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice
    • Levites Y, Jansen K, Smithson LA, Dakin R, Holloway VM, Das P, Golde TE (2006) Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid β40, and amyloid β42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice. J Neurosci 26:11923-11928.
    • (2006) J Neurosci , vol.26 , pp. 11923-11928
    • Levites, Y.1    Jansen, K.2    Smithson, L.A.3    Dakin, R.4    Holloway, V.M.5    Das, P.6    Golde, T.E.7
  • 24
    • 34047206283 scopus 로고    scopus 로고
    • Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-A antibodies
    • DOI 10.1186/1471-2202-8-22
    • Li Q, Gordon M, Cao C, Ugen KE, Morgan D (2007) Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-Abeta antibodies. BMC Neurosci 8:22. (Pubitemid 46534761)
    • (2007) BMC Neuroscience , vol.8 , pp. 22
    • Li, Q.1    Gordon, M.2    Cao, C.3    Ugen, K.E.4    Morgan, D.5
  • 29
    • 4043167747 scopus 로고    scopus 로고
    • A immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • DOI 10.1016/j.neuron.2004.07.003, PII S0896627304004246
    • Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM (2004) Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43:321-332. (Pubitemid 39061125)
    • (2004) Neuron , vol.43 , Issue.3 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    LaFerla, F.M.5
  • 31
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ (2001) Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 81:741-766. (Pubitemid 32267077)
    • (2001) Physiological Reviews , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 32
    • 34147120073 scopus 로고    scopus 로고
    • -site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: Implications for Alzheimer's disease pathogenesis
    • DOI 10.1523/JNEUROSCI.4396-06.2007
    • Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R (2007) β-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: Implications for Alzheimer's disease pathogenesis. J Neurosci 27:3639-3649. (Pubitemid 46557686)
    • (2007) Journal of Neuroscience , vol.27 , Issue.14 , pp. 3639-3649
    • Zhao, J.1    Fu, Y.2    Yasvoina, M.3    Shao, P.4    Hitt, B.5    O'Connor, T.6    Logan, S.7    Maus, E.8    Citron, M.9    Berry, R.10    Binder, L.11    Vassar, R.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.