Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells

Nature Medicine

Volumn 14, Issue 2, 2008, Pages 162-169

  Ding, Yi ^a   Shen, Shiqian ^a   Lino, Andreia C ^a   Curotto De Lafaille, Maria A ^a   Lafaille, Juan J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; TRANSCRIPTION FACTOR FOXP3; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL COUNT; CELL PROTECTION; CELL SURVIVAL; CLONAL ANERGY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENTERITIS; GENE EXPRESSION; GENE THERAPY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN STABILITY; REGULATORY T LYMPHOCYTE;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BETA CATENIN; CELL SURVIVAL; CLONAL ANERGY; COLITIS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; T-LYMPHOCYTES, REGULATORY; THERMODYNAMICS; TRANSDUCTION, GENETIC;

EID: 38949168084     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1707     Document Type: Article

References (39)

1. Gregorieff, A. & Clevers, H. Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev. 19, 877-890 (2005).
2. Reya, T. & Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 843-850 (2005).
3. Willert, K. & Jones, K.A. Wnt signaling: is the party in the nucleus? Genes Dev. 20, 1394-1404 (2006).
4. Amit, S. et al. Axin-mediated CKI phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev. 16, 1066-1076 (2002).
5. Liu, C. et al. Control of β-catenin phosphorylation/ degradation by a dual-kinase mechanism. Cell 108, 837-847 (2002).
6. Jiang, J. & Struhl, G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493-496 (1998).
7. Latres, E., Chiaur, D.S. & Pagano, M. The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-catenin. Oncogene 18, 849-854 (1999).
8. Staal, F.J., Noort Mv, M., Strous, G.J. & Clevers, H.C. Wnt signals are transmitted through N-terminally dephosphorylated β-catenin. EMBO Rep. 3, 63-68 (2002).
9. + regulatory T cells in autoimmunity and allergy. Curr. Opin. Immunol. 14, 771-778 (2002).
10. + T cells. Curr. Opin. Immunol. 15, 690-696 (2003).
11. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6, 345-352 (2005).
12. Bluestone, J.A. & Abbas, A.K. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3, 253-257 (2003).
13. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
14. Apostolou, I. & von Boehmer, H. In vivo instruction of suppressor commitment in naive T cells. J. Exp. Med. 199, 1401-1408 (2004).
15. + regulatory T cells by peripheral expansion. J. Immunol. 173, 7259-7268 (2004).
16. Mucida, D. et al. Oral tolerance in the absence of naturally occurring Tregs. J. Clin. Invest. 115, 1923-1933 (2005).
17. Kretschmer, K. et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat. Immunol. 6, 1219-1227 (2005).
18. Knoechel, B., Lohr, J., Kahn, E., Bluestone, J.A. & Abbas, A.K. Sequential development of interleukin-2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J. Exp. Med. 202, 1375-1386 (2005).
19. Reya, T. et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423, 409-414 (2003).
20. Evan, G.I. et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119-128 (1992).
21. L. Mol. Cell. Biol. 23, 7256-7270 (2003).
22. Dansen, T.B., Whitfield, J., Rostker, F., Brown-Swigart, L. & Evan, G.I. Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo. J. Biol. Chem. 281, 10890-10895 (2006).
23. Soucie, E.L. et al. Myc potentiates apoptosis by stimulating Bax activity at the mitochondria. Mol. Cell. Biol. 21, 4725-4736 (2001).
24. Juin, P. et al. c-Myc functionally cooperates with Bax to induce apoptosis. Mol. Cell. Biol. 22, 6158-6169 (2002).
25. Mitchell, K.O. et al. Bax is a transcriptional target and mediator of c-myc-induced apoptosis. Cancer Res. 60, 6318-6325 (2000).
26. Gavin, M.A. et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 445, 771-775 (2007).
27. + T cells. J. Exp. Med. 183, 2669-2674 (1996).
28. Shen, S. et al. Control of homeostatic proliferation by regulatory T cells. J. Clin. Invest. 115, 3517-3526 (2005).
29. Curotto de Lafaille, M.A. et al. Hyper immunoglobulin E response in mice with monoclonal populations of B and T lymphocytes. J. Exp. Med. 194, 1349-1359 (2001).
30. Gounari, F. et al. Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development. Nat. Immunol. 2, 863-869 (2001).
31. + thymocyte survival. Nat. Immunol. 2, 691-697 (2001).
32. Ohteki, T. et al. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J. Exp. Med. 192, 99-104 (2000).
33. Staal, F.J. et al. Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur. J. Immunol. 31, 285-293 (2001).
34. Mulroy, T., Xu, Y. & Sen, J.M. β-catenin expression enhances generation of mature thymocytes. Int. Immunol. 15, 1485-1494 (2003).
35. Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
36. + regulatory T cells. Nat. Immunol. 4, 330-336 (2003).
37. Lombardi, G., Sidhu, S., Batchelor, R. & Lechler, R. Anergic T cells as suppressor cells in vitro. Science 264, 1587-1589 (1994).
38. Lin, W. et al. Regulatory T cell development in the absence of functional Foxp3. Nat. Immunol. 8, 359-368 (2007).
39. Wu, Y. et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126, 375-387 (2006).