메뉴 건너뛰기




Volumn 14, Issue 6, 2009, Pages 828-837

Epithelial-mesenchymal transition induced by transforming growth factor-β1 in mouse tracheal epithelial cells

Author keywords

Air liquid interface; Airway; Epithelial cell; Epithelial mesenchymal transition; Transforming growth factor 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CELL MARKER; CYTOKERATIN 17; CYTOKERATIN 5; GELATINASE B; OCCLUDIN; PROTEIN ZO1; TRANSFORMING GROWTH FACTOR BETA1; VIMENTIN;

EID: 69049103163     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2009.01561.x     Document Type: Article
Times cited : (22)

References (40)
  • 1
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil J, Bottinger EP. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005 24 : 5764 5774.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 2
    • 17844384822 scopus 로고    scopus 로고
    • Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: Potential role in idiopathic pulmonary fibrosis
    • Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED et al. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am. J. Pathol. 2005 166 : 1321 1332.
    • (2005) Am. J. Pathol. , vol.166 , pp. 1321-1332
    • Willis, B.C.1    Liebler, J.M.2    Luby-Phelps, K.3    Nicholson, A.G.4    Crandall, E.D.5
  • 3
    • 0032842887 scopus 로고    scopus 로고
    • Transforming growth factor-beta regulates tubular epithelial- myofibroblast transdifferentiation in vitro
    • Fan JM, Ng YY, Hill PA, Nikolic-Paterson DJ, Mu W et al. Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro. Kidney Int. 1999 56 : 1455 1467.
    • (1999) Kidney Int. , vol.56 , pp. 1455-1467
    • Fan, J.M.1    Ng, Y.Y.2    Hill, P.A.3    Nikolic-Paterson, D.J.4    Mu, W.5
  • 4
    • 1542289674 scopus 로고    scopus 로고
    • Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury
    • Saika S, Kono-Saika S, Ohnishi Y, Sato M, Muragaki Y et al. Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury. Am. J. Pathol. 2004 164 : 651 663.
    • (2004) Am. J. Pathol. , vol.164 , pp. 651-663
    • Saika, S.1    Kono-Saika, S.2    Ohnishi, Y.3    Sato, M.4    Muragaki, Y.5
  • 5
    • 0028670258 scopus 로고
    • Expression of beta 1 integrins changes during transformation of avian lens epithelium to mesenchyme in collagen gels
    • Zuk A, Hay ED. Expression of beta 1 integrins changes during transformation of avian lens epithelium to mesenchyme in collagen gels. Dev. Dyn. 1994 201 : 378 393.
    • (1994) Dev. Dyn. , vol.201 , pp. 378-393
    • Zuk, A.1    Hay, E.D.2
  • 6
    • 0028567054 scopus 로고
    • TGF-beta 1 induces lens cells to accumulate alpha-smooth muscle actin, a marker for subcapsular cataracts
    • Hales AM, Schulz MW, Chamberlain CG, McAvoy JW. TGF-beta 1 induces lens cells to accumulate alpha-smooth muscle actin, a marker for subcapsular cataracts. Curr. Eye Res. 1994 13 : 885 890.
    • (1994) Curr. Eye Res. , vol.13 , pp. 885-890
    • Hales, A.M.1    Schulz, M.W.2    Chamberlain, C.G.3    McAvoy, J.W.4
  • 7
    • 0036322007 scopus 로고    scopus 로고
    • Evidence that fibroblasts derive from epithelium during tissue fibrosis
    • Iwano M, Plieth D, Danoff TM, Xue C, Okada H et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest. 2002 110 : 341 350.
    • (2002) J. Clin. Invest. , vol.110 , pp. 341-350
    • Iwano, M.1    Plieth, D.2    Danoff, T.M.3    Xue, C.4    Okada, H.5
  • 8
    • 0028603343 scopus 로고
    • TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
    • Miettinen PJ, Ebner R, Lopez AR, Derynck R. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell Biol. 1994 127 : 2021 2036.
    • (1994) J. Cell Biol. , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3    Derynck, R.4
  • 9
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 2003 112 : 1776 1784.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 10
    • 8544230635 scopus 로고    scopus 로고
    • Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis
    • Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am. J. Respir. Crit. Care Med. 1997 156 : 591 599.
    • (1997) Am. J. Respir. Crit. Care Med. , vol.156 , pp. 591-599
    • Vignola, A.M.1    Chanez, P.2    Chiappara, G.3    Merendino, A.4    Pace, E.5
  • 12
    • 0034721104 scopus 로고    scopus 로고
    • Elevated levels of interleukin-8 and transforming growth factor-beta in bronchoalveolar lavage fluid from patients with bronchiolitis obliterans syndrome: Proinflammatory role of bronchial epithelial cells
    • Munich Lung Transplant Group.
    • Elssner A, Jaumann F, Dobmann S, Behr J, Schwaiblmair M et al. Elevated levels of interleukin-8 and transforming growth factor-beta in bronchoalveolar lavage fluid from patients with bronchiolitis obliterans syndrome: proinflammatory role of bronchial epithelial cells. Munich Lung Transplant Group. Transplantation 2000 70 : 362 367.
    • (2000) Transplantation , vol.70 , pp. 362-367
    • Elssner, A.1    Jaumann, F.2    Dobmann, S.3    Behr, J.4    Schwaiblmair, M.5
  • 13
    • 0037080782 scopus 로고    scopus 로고
    • Asthmatic epithelial cell proliferation and stimulation of collagen production: Human asthmatic epithelial cells stimulate collagen type III production by human lung myofibroblasts after segmental allergen challenge
    • Hastie AT, Kraft WK, Nyce KB, Zangrilli JG, Musani AI et al. Asthmatic epithelial cell proliferation and stimulation of collagen production: human asthmatic epithelial cells stimulate collagen type III production by human lung myofibroblasts after segmental allergen challenge. Am. J. Respir. Crit. Care Med. 2002 165 : 266 272.
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , pp. 266-272
    • Hastie, A.T.1    Kraft, W.K.2    Nyce, K.B.3    Zangrilli, J.G.4    Musani, A.I.5
  • 15
    • 11144358047 scopus 로고    scopus 로고
    • Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression
    • Woodruff PG, Dolganov GM, Ferrando RE, Donnelly S, Hays SR et al. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am. J. Respir. Crit. Care Med. 2004 169 : 1001 1006.
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , pp. 1001-1006
    • Woodruff, P.G.1    Dolganov, G.M.2    Ferrando, R.E.3    Donnelly, S.4    Hays, S.R.5
  • 18
    • 0034721485 scopus 로고    scopus 로고
    • Epithelial re-growth is associated with inhibition of obliterative airway disease in orthotopic tracheal allografts in non-immunosuppressed rats
    • Ikonen TS, Brazelton TR, Berry GJ, Shorthouse RS, Morris RE. Epithelial re-growth is associated with inhibition of obliterative airway disease in orthotopic tracheal allografts in non-immunosuppressed rats. Transplantation 2000 70 : 857 863.
    • (2000) Transplantation , vol.70 , pp. 857-863
    • Ikonen, T.S.1    Brazelton, T.R.2    Berry, G.J.3    Shorthouse, R.S.4    Morris, R.E.5
  • 19
    • 26944463075 scopus 로고    scopus 로고
    • Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients
    • Ward C, Forrest IA, Murphy DM, Johnson GE, Robertson H et al. Phenotype of airway epithelial cells suggests epithelial to mesenchymal cell transition in clinically stable lung transplant recipients. Thorax 2005 60 : 865 871.
    • (2005) Thorax , vol.60 , pp. 865-871
    • Ward, C.1    Forrest, I.A.2    Murphy, D.M.3    Johnson, G.E.4    Robertson, H.5
  • 20
    • 34347364932 scopus 로고    scopus 로고
    • Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse
    • Wu Z, Yang L, Cai L, Zhang M, Cheng X et al. Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir. Res. 2007 8 : 1.
    • (2007) Respir. Res. , vol.8 , pp. 1
    • Wu, Z.1    Yang, L.2    Cai, L.3    Zhang, M.4    Cheng, X.5
  • 21
    • 0036891878 scopus 로고    scopus 로고
    • Growth and differentiation of mouse tracheal epithelial cells: Selection of a proliferative population
    • You Y, Richer EJ, Huang T, Brody SL. Growth and differentiation of mouse tracheal epithelial cells: selection of a proliferative population. Am. J. Physiol. Lung Cell. Mol. Physiol. 2002 283 : L1315 21.
    • (2002) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.283
    • You, Y.1    Richer, E.J.2    Huang, T.3    Brody, S.L.4
  • 22
    • 40749108505 scopus 로고    scopus 로고
    • Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cells
    • Fujisawa T, Ide K, Holtzman MJ, Suda T, Suzuki K et al. Involvement of the p38 MAPK pathway in IL-13-induced mucous cell metaplasia in mouse tracheal epithelial cells. Respirology 2008 13 : 191 202.
    • (2008) Respirology , vol.13 , pp. 191-202
    • Fujisawa, T.1    Ide, K.2    Holtzman, M.J.3    Suda, T.4    Suzuki, K.5
  • 23
    • 32444436464 scopus 로고    scopus 로고
    • Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
    • Tyner JW, Kim EY, Ide K, Pelletier MR, Roswit WT et al. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. J. Clin. Invest. 2006 116 : 309 321.
    • (2006) J. Clin. Invest. , vol.116 , pp. 309-321
    • Tyner, J.W.1    Kim, E.Y.2    Ide, K.3    Pelletier, M.R.4    Roswit, W.T.5
  • 24
    • 34547599359 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
    • Kaimori A, Potter J, Kaimori JY, Wang C, Mezey E et al. Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J. Biol. Chem. 2007 282 : 22089 101.
    • (2007) J. Biol. Chem. , vol.282 , pp. 22089-22101
    • Kaimori, A.1    Potter, J.2    Kaimori, J.Y.3    Wang, C.4    Mezey, E.5
  • 25
    • 0033178473 scopus 로고    scopus 로고
    • Mechanisms of myofibroblast activity and phenotypic modulation
    • Serini G, Gabbiani G. Mechanisms of myofibroblast activity and phenotypic modulation. Exp. Cell Res. 1999 250 : 273 283.
    • (1999) Exp. Cell Res. , vol.250 , pp. 273-283
    • Serini, G.1    Gabbiani, G.2
  • 26
    • 0033524949 scopus 로고    scopus 로고
    • The integrin alpha v beta 6 binds and activates latent TGF beta 1: A mechanism for regulating pulmonary inflammation and fibrosis
    • Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL et al. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999 96 : 319 328.
    • (1999) Cell , vol.96 , pp. 319-328
    • Munger, J.S.1    Huang, X.2    Kawakatsu, H.3    Griffiths, M.J.4    Dalton, S.L.5
  • 27
    • 6344254484 scopus 로고    scopus 로고
    • TGF-beta1 induces alveolar epithelial to mesenchymal transition in vitro
    • Yao HW, Xie QM, Chen JQ, Deng YM, Tang HF. TGF-beta1 induces alveolar epithelial to mesenchymal transition in vitro. Life Sci. 2004 76 : 29 37.
    • (2004) Life Sci. , vol.76 , pp. 29-37
    • Yao, H.W.1    Xie, Q.M.2    Chen, J.Q.3    Deng, Y.M.4    Tang, H.F.5
  • 28
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir. Res. 2005 6 : 56.
    • (2005) Respir. Res. , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 29
    • 36148956552 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces epithelial-to-mesenchymal transition of A549 cells
    • Kim JH, Jang YS, Eom KS, Hwang YI, Kang HR et al. Transforming growth factor beta1 induces epithelial-to-mesenchymal transition of A549 cells. J. Korean Med. Sci. 2007 22 : 898 904.
    • (2007) J. Korean Med. Sci. , vol.22 , pp. 898-904
    • Kim, J.H.1    Jang, Y.S.2    Eom, K.S.3    Hwang, Y.I.4    Kang, H.R.5
  • 30
    • 43149111275 scopus 로고    scopus 로고
    • Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1
    • Alcorn JF, Guala AS, van der Velden J, McElhinney B, Irvin CG et al. Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J. Cell Sci. 2008 121 : 1036 1045.
    • (2008) J. Cell Sci. , vol.121 , pp. 1036-1045
    • Alcorn, J.F.1    Guala, A.S.2    Van Der Velden, J.3    McElhinney, B.4    Irvin, C.G.5
  • 32
    • 33244472554 scopus 로고    scopus 로고
    • Histological types and significance of bronchial epithelial dysplasia
    • Wang GF, Lai MD, Yang RR, Chen PH, Su YY et al. Histological types and significance of bronchial epithelial dysplasia. Mod. Pathol. 2006 19 : 429 437.
    • (2006) Mod. Pathol. , vol.19 , pp. 429-437
    • Wang, G.F.1    Lai, M.D.2    Yang, R.R.3    Chen, P.H.4    Su, Y.Y.5
  • 33
    • 0026710986 scopus 로고
    • Regional assignment of the human keratin 5 (KRT5) gene to chromosome 12q near D12S14 by PCR analysis of somatic cell hybrids and multicolor in situ hybridization
    • Bonifas JM, Bare JW, Lynch ED, Lebo RV, Epstein EH Jr. Regional assignment of the human keratin 5 (KRT5) gene to chromosome 12q near D12S14 by PCR analysis of somatic cell hybrids and multicolor in situ hybridization. Genomics 1992 13 : 452 454.
    • (1992) Genomics , vol.13 , pp. 452-454
    • Bonifas, J.M.1    Bare, J.W.2    Lynch, E.D.3    Lebo, R.V.4    Epstein Jr., E.H.5
  • 35
    • 0034668172 scopus 로고    scopus 로고
    • Induction and regulation of epithelial-mesenchymal transitions
    • Boyer B, Valles AM, Edme N. Induction and regulation of epithelial-mesenchymal transitions. Biochem. Pharmacol. 2000 60 : 1091 1099.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1091-1099
    • Boyer, B.1    Valles, A.M.2    Edme, N.3
  • 36
    • 30144440059 scopus 로고    scopus 로고
    • Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders
    • Bertolino P, Deckers M, Lebrin F, ten Dijke P. Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders. Chest 2005 128 : 585S 90S.
    • (2005) Chest , vol.128
    • Bertolino, P.1    Deckers, M.2    Lebrin, F.3    Ten Dijke, P.4
  • 37
    • 0030800795 scopus 로고    scopus 로고
    • Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung
    • Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J. Clin. Invest. 1997 100 : 768 776.
    • (1997) J. Clin. Invest. , vol.100 , pp. 768-776
    • Sime, P.J.1    Xing, Z.2    Graham, F.L.3    Csaky, K.G.4    Gauldie, J.5
  • 39
    • 3242799550 scopus 로고    scopus 로고
    • Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis
    • Bonniaud P, Kolb M, Galt T, Robertson J, Robbins C et al. Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis. J. Immunol. 2004 173 : 2099 2108.
    • (2004) J. Immunol. , vol.173 , pp. 2099-2108
    • Bonniaud, P.1    Kolb, M.2    Galt, T.3    Robertson, J.4    Robbins, C.5
  • 40
    • 0036854980 scopus 로고    scopus 로고
    • Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
    • Yang J, Shultz RW, Mars WM, Wegner RE, Li Y et al. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J. Clin. Invest. 2002 110 : 1525 1538.
    • (2002) J. Clin. Invest. , vol.110 , pp. 1525-1538
    • Yang, J.1    Shultz, R.W.2    Mars, W.M.3    Wegner, R.E.4    Li, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.