The role of hypoxia in 2-butoxyethanol-Induced hemangiosarcoma

Toxicological Sciences

Volumn 113, Issue 1, 2009, Pages 254-266

  Laifenfeld, Daphna ^a   Gilchrist, Annalyn ^a   Drubin, David ^a   Jorge, Milena ^a   Eddy, Sean F ^a   Frushour, Brian P ^a   Ladd, Bill ^a   Obert, Leslie A ^b   Gosink, Mark M ^b   Cook, Jon C ^b   Criswell, Kay ^b   Somps, Christopher J ^b   Koza Taylor, Petra ^b   Elliston, Keith O ^a   Lawton, Michael P ^b  

^a Genstruct Inc   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

2 butoxyethanol; Angiogenesis; Endothelial cells; Endothelial precursor cells; Hemangiosarcoma; Human relevance; Hypoxia; Mechanism of action

Indexed keywords

2 BUTOXYETHANOL; ACETYLCHOLINESTERASE; ALPHA4 INTEGRIN; CD47 ANTIGEN; ERYTHROCYTE BAND 3 PROTEIN; ERYTHROPOIETIN; GLYCOPHORIN A; HEMOGLOBIN; HEMOGLOBIN X; HEMOGLOBIN Y; HEMOGLOBIN Z; RHESUS D ANTIGEN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ANGIOSARCOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ERYTHROCYTE COUNT; ERYTHROPOIESIS; GENE EXPRESSION; GENOMIC INSTABILITY; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HEPATITIS; HISTOPATHOLOGY; HYPOXIA; IMMUNOHISTOCHEMISTRY; LIVER; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; RETICULOCYTE COUNT; SIGNAL TRANSDUCTION; SPLEEN; TRANSCRIPTOMICS;

ANIMALS; BONE MARROW; CELL CYCLE; CELL DIFFERENTIATION; CELL HYPOXIA; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ERYTHROPOIESIS; ERYTHROPOIETIN; ETHYLENE GLYCOLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOMIC INSTABILITY; HEMANGIOSARCOMA; HEMATOPOIETIC STEM CELLS; HEMOLYSIS; HEPATITIS; IMMUNOHISTOCHEMISTRY; LIVER; MACROPHAGE ACTIVATION; MALE; MICE; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SPLEEN; SYSTEMS BIOLOGY; TIME FACTORS;

MUS;

EID: 69049087456     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp213     Document Type: Article

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