Toxicity and carcinogenicity of Elmiron in F344/N rats and B6C3F 1 mice following 2 years of gavage administration

Archives of Toxicology

Volumn 77, Issue 12, 2003, Pages 702-711

  Abdo, Kamal M ^a   Johnson, Jerry D ^b   Nyska, Abraham ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

Carcinogenicity; Elmiron; Rodents; Sodium pentosan polysulfate; Toxicity

Indexed keywords

PENTOSAN POLYSULFATE;

ANGIOSARCOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CARCINOGENICITY; CELL STRUCTURE; CELL VACUOLE; CHRONIC TOXICITY; CONTROLLED STUDY; CYTOPLASM; DRUG INFORMATION; DRUG SAFETY; ENTERITIS; FEEDING; FEMALE; HISTIOCYTE; HYPERPLASIA; LIVER CANCER; LIVER CELL CARCINOMA; LUNG; LYMPHOMA; MALE; MESENTERY LYMPH NODE; MOUSE; MOUSE STRAIN; MYXOMA; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RECTUM; SPECIES DIFFERENCE; SPLEEN; SQUAMOUS CELL METAPLASIA;

ANIMALS; ANTICOAGULANTS; BODY WEIGHT; CARCINOGENICITY TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LIVER; MALE; MICE; MICE, INBRED STRAINS; PENTOSAN SULFURIC POLYESTER; RATS; RATS, INBRED F344; SPECIES SPECIFICITY; SURVIVAL ANALYSIS; TIME FACTORS;

ANIMALIA; RODENTIA;

EID: 0346373755     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-003-0472-9     Document Type: Article

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