Mechanisms of 2-butoxyethanol-induced hemangiosarcomas

Toxicological Sciences

Volumn 92, Issue 2, 2006, Pages 378-386

  Corthals, Stacy M ^a   Kamendulis, Lisa M ^a   Klaunig, James E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

2 butoxyethanol; DNA damage; Endothelial cells; Hemolysis; Liver hemangiosarcomas; Macrophages

Indexed keywords

2 BUTOXYACETALDEHYDE; 2 BUTOXYACETIC ACID; 2 BUTOXYETHANOL; ACETALDEHYDE; ACETIC ACID DERIVATIVE; CELL DNA; FERROUS SULFATE; HYDROGEN PEROXIDE; IRON; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANGIOSARCOMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL STIMULATION; COCULTURE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA SYNTHESIS; ENDOTHELIUM CELL; ERYTHROCYTE; HEMOLYSIS; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN;

ACETALDEHYDE; ANIMALS; CELL LINE; COMET ASSAY; DNA DAMAGE; ENDOTHELIAL CELLS; ERYTHROCYTES; ETHYLENE GLYCOLS; FERROUS COMPOUNDS; GLYCOLATES; HEMANGIOSARCOMA; HEMOLYSIS; HYDROGEN PEROXIDE; KUPFFER CELLS; MACROPHAGE ACTIVATION; MICE; SOLVENTS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 33745794453     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl007     Document Type: Article

References (47)

1. Arii, S., and Imamura, M. (2000). Physiological role of sinusoidal endothelial cells and Kupffer cells and their implication in the pathogenesis of liver injury. J. Hepatobiliary Pancreat. Surg. 7, 40-48.
2. Aust, S. D., Morehouse, L. A., and Thomas, C. E. (1985). Role of metals in oxygen radical reactions. J. Free Radic. Biol. Med. 1, 3-25.
3. Bacon, B. R., and Britton, R. S. (1990). The pathology of hepatic iron overload: A free radical-mediated process? Hepatology 11, 127-137.
4. Bartnik, F. G., Reddy, A. K., Klecak, G., Zimmermann, V., Hostynek, J. J., and Kunstler, K. (1987). Percutaneous absorption, metabolism, and hemolytic activity of n-butoxyethanol. Fundam. Appl. Toxicol. 8, 59-70.
5. Britton, R. S., Bacon, B. R., and Recknagel, R. O. (1987). Lipid peroxidation and associated hepatic organelle dysfunction in iron overload. Chem. Phys. Lipids 45, 207-239.
6. Cerutti, P. A. (1985). Prooxidant states and tumor promotion. Science 227, 375-381.
7. Decker, K. (1990). Biologically active products of stimulated liver macrophages (Kupffer cells) Eur. J. Biochem. 192, 245-261.
8. Deisinger, P. J., and Boatman, R. J. (2004). In vivo metabolism and kinetics of ethylene glycol monobutyl ether and its metabolites, 2-butoxyacetaldehyde and 2-butoxyacetic acid, as measured in blood, liver and forestomach of mice. Xenobiotica 34, 675-685.
9. Dill, J. A., Lee, K. M., Bates, D. J., Anderson, D. J., Johnson, R. E., Chou, B. J., Burka, L. T., and Roycroft, J. H. (1998). Toxicokinetics of inhaled 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in F344 rats and B6C3F1 mice. Toxicol. Appl. Pharmacol. 153, 227-242.
10. Dizdaroglu, M. (1992). Measurement of radiation-induced damage to DNA at the molecular level. Int. J. of Radiat. Biol. 61, 175-183.
11. Elliott, B. M., and Ashby, J. (1997). Review of the genotoxicity of 2-butoxyethanol. Mutat. Res. 387, 89-96.
12. Ghanayem, B. I. (1989). Metabolic and cellular basis of 2-butoxyethanol-induced hemolytic anemia in rats and assessment of human risk in vitro. Biochem. Pharmacol. 38, 1679-1684.
13. Ghanayem, B. I., Blair, P. C., Thompson, M. B., Maronpot, R. R., and Matthews, H. B. (1987a). Effect of age on the toxicity and metabolism of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Toxicol. Appl. Pharmacol. 91, 222-234.
14. Ghanayem, B. I., Burka, L. T., and Matthews, H. B. (1987b). Metabolic basis of ethylene glycol monobutyl ether (2-butoxyethanol) toxicity: Role of alcohol and aldehyde dehydrogenases. J. Pharmacol. Exp. Ther. 242, 222-231.
15. Ghanayem, B. I., Burka, L. T., Sanders, J. M., and Matthews, H. B. (1987c). Metabolism and disposition of ethylene glycol monobutyl ether (2-butoxyethanol) in rats. Drug Metab. Dispos. 15, 478-484.
16. Ghanayem, B. I., and Sullivan, C. A. (1993). Assessment of the haemolytic activity of 2-butoxyethanol and its major metabolite, butoxyacetic acid, in various mammals including humans. Hum. Exp. Toxicol. 12, 305-311.
17. Goldsworthy, T. L., Butterworth, B. E., and Maronpot, R. R. (1993). Concepts, labeling procedures, and design of cell proliferation studies relating to carcinogenesis. Environ. Health Perspect. 101(Suppl. 5), 59-65.
18. Halliwell, B., and Gutteridge, J. M. (1984). Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219, 1-14.
19. Hoflack, J. C., Lambolez, L., Elias, Z., and Vasseur, P. (1995). Mutagenicity of ethylene glycol ethers and of their metabolites in Salmonella typhimurium his. Mutat. Res. 341, 281-287.
20. James, N. H., and Roberts, R. A. (1996). Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than suppression of apoptosis. Carcinogenesis 17, 1623-1632.
21. Jaruga, P., and Dizdaroglu, M. (1996). Repair of products of oxidative DNA base damage in human cells. Nucleic Acids Res. 24, 1389-1394.
22. Klaunig, J. E., and Kamendulis, L. M. (2004). The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 44, 239-267.
23. Klaunig, J. E., and Kamendulis, L. M. (2005). Mode of action of butoxyethanol-induced mouse liver hemangiosarcomas and hepatocellular carcinomas. Toxicol. Lett. 28, 107-115.
24. Knolle, P., Lohr, H., Treichel, U., Dienes, H. P., Lohse, A., Schlaack, J., and Gerken, G. (1995). Parenchymal and nonparenchymal liver cells and their interaction in the local immune response. Z. Gastroenterol. 33, 613-620.
25. Krasavage, W. J. (1986). Subchronic oral toxicity of ethylene glycol monobutyl ether in male rats. Fundam. Appl. Toxicol. 6, 349-355.
26. Lee, K. M., Dill, J. A., Chou, B. J., and Roycroft, J. H. (1998). Physiologically based pharmacokinetic model for chronic inhalation of 2-butoxyethanol. Toxicol. Appl. Pharmacol. 153, 211-226.
27. Ley, T. J., Griffith, P., and Nienhuis, A. W. (1982). Transfusion haemosiderosis and chelation therapy. Clin. Haematol. 11, 437-464.
28. Mandishona, E., MacPhail, A. P., Gordeuk, V. R., Kedda, M. A., Paterson, A. C., Rouault, T. A., and Kew, M. C. (1998). Dietary iron overload as a risk factor for hepatocellular carcinoma in Black Africans. Hepatology 27, 1563-1566.
29. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
30. National Toxicology Program (NTP) (2000). Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CAS NO. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). National Toxicology Program. NIH Publication No. 00-3974
31. Niederau, C., Fischer, R., Sonnenberg, A., Stremmel, W., Trampisch, H. J., and Strohmeyer, G. (1985). Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N. Engl. J. Med. 313, 1256-1262.
32. Nyska, A., Haseman, J. K., Kohen, R., and Maronpot, R. R. (2004). Association of liver hemangiosarcoma and secondary iron overload in B6C3F1 mice - The national toxicology program experience. Toxicol. Pathol. 32, 222-228.
33. Park, J., Kamendulis, L. M., and Klaunig, J. E. (2002a). Effects of 2-butoxyethanol on hepatic oxidative damage. Toxicol. Lett. 126, 19-29.
34. Park, J., Kamendulis, L. M., and Klaunig, J. E. (2002b). Mechanisms of 2-butoxyethanol carcinogenicity: Studies on Syrian Hamster Embryo (SHE) cell transformation. Toxicol. Sci. 68, 43-50.
35. Parola, M., and Robino, G. (2001). Oxidative stress-related molecules and liver fibrosis. J. Hepatol. 35, 297-306.
36. Rojas, E., Lopez, M. C., and Valverde, M. (1999). Single cell gel electrophoresis assay: Methodology and applications. J. Chromatogr. B Biomed. Sci. Appl. 722, 225-254.
37. Searle, J. W., Kerr, J. F. R., Halliday, J. W., and Powell, L. W. (1987). Iron storage disease. In Pathology of the Liver (R. N. M. MacSween, P. P. Anthony, and P. J. Scheuer, Eds.), pp. 181-201. Churchill Livingstone, Edinburgh, New York.
38. She, H., Xiong, S., Lin, M., Zandi, E., Giulivi, C., and Tsukamoto, H. (2002). Iron activates NF-kappaB in Kupffer cells. Am. J. Physiol. Gastrointest. Liver Physiol. 283, G719-G726.
39. Siesky, A. M., Kamendulis, L. M., and Klaunig, J. E. (2002). Hepatic effects of 2-butoxyethanol in rodents. Toxicol. Sci. 70, 252-260.
40. Singh, N. P., McCoy, M. T., Tice, R. R., and Schneider, E. L. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184-191.
41. Stevens, R. G., Graubard, B. I., Micozzi, M. S., Neriishi, K., and Blumberg, B. S. (1994). Moderate elevation of body iron level and increased risk of cancer occurrence and death. Int. J. Cancer 56, 364-369.
42. Sunderkotter, C., Steinbrink, K., Goebeler, M., Bhardwaj, R., and Sorg, C. (1994). Macrophages and angiogenesis. J. Leukoc. Biol. 55, 410-422.
43. Terpstra, V., and van Berkel, T. J. (2000). Scavenger receptors on liver Kupffer cells mediate the in vivo uptake of oxidatively damaged red blood cells in mice. Blood 95, 2157-2163.
44. Tice, R. R., Andrews, P. W., Hirai, O., and Singh, N. P. (1991). The single cell gel (SCG) assay: An electrophoretic technique for the detection of DNA damage in individual cells. Adv. Exp. Med. Biol. 283, 157-164.
45. Udden, M. M. (1994). Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol: II. Resistance in red blood cells from humans with potential susceptibility J. Appl. Toxicol. 14, 97-102.
46. Udden, M. M. (2000). Rat erythrocyte morphological changes after gavage dosing with 2-butoxyethanol: A comparison with the in vitro effects of butoxyacetic acid on rat and human erythrocytes. J. Appl. Toxicol. 20, 381-387.
47. Udden, M. M., and Patton, C. S. (1994). Hemolysis and deformability of erythrocytes exposed to butoxyacetic acid, a metabolite of 2-butoxyethanol: I. Sensitivity in rats and resistance in normal humans. J. Appl. Toxicol. 14, 91-96.