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Volumn 10, Issue 9, 2009, Pages 628-638

Microfluidic devices for measuring gene network dynamics in single cells

Author keywords

[No Author keywords available]

Indexed keywords

DIMETICONE; GREEN FLUORESCENT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 68949215494     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg2625     Document Type: Review
Times cited : (210)

References (128)
  • 1
    • 63249117139 scopus 로고    scopus 로고
    • The role of predictive modelling in rationally re-engineering biological systems
    • Koide, T., Pang, W. L. & Baliga, N. S. The role of predictive modelling in rationally re-engineering biological systems. Nature Rev. Microbiol. 7, 297-305 (2009).
    • (2009) Nature Rev. Microbiol , vol.7 , pp. 297-305
    • Koide, T.1    Pang, W.L.2    Baliga, N.S.3
  • 2
    • 0023709196 scopus 로고
    • Metabolic control theory: A structural approach
    • Reder, C. Metabolic control theory: a structural approach. J. Theor. Biol. 135, 175-201 (1988).
    • (1988) J. Theor. Biol , vol.135 , pp. 175-201
    • Reder, C.1
  • 3
    • 0036001069 scopus 로고    scopus 로고
    • Metabolic modelling of microbes: The flux-balance approach
    • Edwards, J. S., Covert, M. & Palsson, B. Metabolic modelling of microbes: the flux-balance approach. Environ. Microbiol. 4, 133-140 (2002).
    • (2002) Environ. Microbiol , vol.4 , pp. 133-140
    • Edwards, J.S.1    Covert, M.2    Palsson, B.3
  • 4
    • 38449101120 scopus 로고    scopus 로고
    • Integration of biological networks and gene expression data using Cytoscape
    • Cline, M. S. et al. Integration of biological networks and gene expression data using Cytoscape. Nature Protoc. 2, 2366-2382 (2007).
    • (2007) Nature Protoc , vol.2 , pp. 2366-2382
    • Cline, M.S.1
  • 5
    • 0037079012 scopus 로고    scopus 로고
    • Engineered gene circuits
    • Hasty, J., McMillen, D. & Collins, J. J. Engineered gene circuits. Nature 420, 224-230 (2002).
    • (2002) Nature , vol.420 , pp. 224-230
    • Hasty, J.1    McMillen, D.2    Collins, J.J.3
  • 6
    • 0033988843 scopus 로고    scopus 로고
    • Fabrication of microfluidic systems in poly(dimethylsiloxane)
    • McDonald, J. C. et al. Fabrication of microfluidic systems in poly(dimethylsiloxane). Electrophoresis 21, 27-40 (2000).
    • (2000) Electrophoresis , vol.21 , pp. 27-40
    • McDonald, J.C.1
  • 8
    • 0036811407 scopus 로고    scopus 로고
    • Components for integrated poly(dimethylsiloxane) microfluidic systems
    • References 6-8 are good reviews covering the design and manufacture of microfluidic devices
    • Ng, J. M., Gitlin, I., Stroock, A. D. & Whitesides, G. M. Components for integrated poly(dimethylsiloxane) microfluidic systems. Electrophoresis 23, 3461-3473 (2002). References 6-8 are good reviews covering the design and manufacture of microfluidic devices.
    • (2002) Electrophoresis , vol.23 , pp. 3461-3473
    • Ng, J.M.1    Gitlin, I.2    Stroock, A.D.3    Whitesides, G.M.4
  • 9
    • 0347134477 scopus 로고    scopus 로고
    • Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies
    • Sia, S. K. & Whitesides, G. M. Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies. Electrophoresis 24, 3563-3576 (2003).
    • (2003) Electrophoresis , vol.24 , pp. 3563-3576
    • Sia, S.K.1    Whitesides, G.M.2
  • 10
    • 1642460171 scopus 로고    scopus 로고
    • Lidstrom, M. E. & Meldrum, D. R. Life-on-a-chip. Nature Rev. Microbiol. 1, 158-164 (2003).
    • Lidstrom, M. E. & Meldrum, D. R. Life-on-a-chip. Nature Rev. Microbiol. 1, 158-164 (2003).
  • 12
    • 55249096780 scopus 로고    scopus 로고
    • Microfluidic single-cell analysis of intracellular compounds
    • Chao, T. C. & Ros, A. Microfluidic single-cell analysis of intracellular compounds. J. R. Soc. Interface 5 (Suppl. 2), S139-S150 (2008).
    • (2008) J. R. Soc. Interface , vol.5 , Issue.SUPPL. 2
    • Chao, T.C.1    Ros, A.2
  • 13
    • 46149110780 scopus 로고    scopus 로고
    • Cell research with physically modified microfluidic channels: A review
    • Kim, S. M., Lee, S. H. & Suh, K. Y. Cell research with physically modified microfluidic channels: a review. Lab Chip 8, 1015-1023 (2008).
    • (2008) Lab Chip , vol.8 , pp. 1015-1023
    • Kim, S.M.1    Lee, S.H.2    Suh, K.Y.3
  • 14
    • 65649093731 scopus 로고    scopus 로고
    • Microfluidics technology for systems biology research
    • Wang, C. J. & Levchenko, A. Microfluidics technology for systems biology research. Methods Mol. Biol. 500, 203-219 (2009).
    • (2009) Methods Mol. Biol , vol.500 , pp. 203-219
    • Wang, C.J.1    Levchenko, A.2
  • 15
    • 34548576414 scopus 로고
    • Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan
    • Shimomura, O., Johnson, F. H. & Saiga, Y. Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea. J. Cell Comp. Physiol. 59, 223-239 (1962).
    • (1962) Aequorea. J. Cell Comp. Physiol , vol.59 , pp. 223-239
    • Shimomura, O.1    Johnson, F.H.2    Saiga, Y.3
  • 17
    • 30944467113 scopus 로고    scopus 로고
    • A guide to choosing fluorescent proteins
    • References 15-17 detail the properties of various fluorescent proteins that are commonly used in synthetic biology
    • Shaner, N. C., Steinbach, P. A. & Tsien, R. Y. A guide to choosing fluorescent proteins. Nature Methods 2, 905-909 (2005). References 15-17 detail the properties of various fluorescent proteins that are commonly used in synthetic biology.
    • (2005) Nature Methods , vol.2 , pp. 905-909
    • Shaner, N.C.1    Steinbach, P.A.2    Tsien, R.Y.3
  • 18
    • 0037119587 scopus 로고    scopus 로고
    • Stochastic gene expression in a single cell
    • Elowitz, M. B., Levine, A. J., Siggia, E. D. & Swain, P. S. Stochastic gene expression in a single cell. Science 297, 1183-1186 (2002).
    • (2002) Science , vol.297 , pp. 1183-1186
    • Elowitz, M.B.1    Levine, A.J.2    Siggia, E.D.3    Swain, P.S.4
  • 19
    • 28944434119 scopus 로고    scopus 로고
    • Real-time kinetics of gene activity in individual bacteria
    • Golding, I., Paulsson, J., Zawilski, S. M. & Cox, E. C. Real-time kinetics of gene activity in individual bacteria. Cell 123, 1025-1036 (2005).
    • (2005) Cell , vol.123 , pp. 1025-1036
    • Golding, I.1    Paulsson, J.2    Zawilski, S.M.3    Cox, E.C.4
  • 20
    • 34250191761 scopus 로고    scopus 로고
    • RNA visualization in live bacterial cells using fluorescent protein complementation
    • Valencia-Burton, M., McCullough, R. M., Cantor, C. R. & Broude, N. E. RNA visualization in live bacterial cells using fluorescent protein complementation. Nature Methods 4, 421-427 (2007).
    • (2007) Nature Methods , vol.4 , pp. 421-427
    • Valencia-Burton, M.1    McCullough, R.M.2    Cantor, C.R.3    Broude, N.E.4
  • 21
    • 34250206603 scopus 로고    scopus 로고
    • Splitting or stacking fluorescent proteins to visualize mRNA in living cells
    • Tyagi, S. Splitting or stacking fluorescent proteins to visualize mRNA in living cells. Nature Methods 4, 391-392 (2007).
    • (2007) Nature Methods , vol.4 , pp. 391-392
    • Tyagi, S.1
  • 22
    • 34250219568 scopus 로고    scopus 로고
    • A genomic integration method to visualize localization of endogenous mRNAs in living yeast
    • Haim, L., Zipor, G., Aronov, S. & Gerst, J. E. A genomic integration method to visualize localization of endogenous mRNAs in living yeast. Nature Methods 4, 409-412 (2007).
    • (2007) Nature Methods , vol.4 , pp. 409-412
    • Haim, L.1    Zipor, G.2    Aronov, S.3    Gerst, J.E.4
  • 23
    • 57049159362 scopus 로고    scopus 로고
    • Stricker, J. et al. A fast, robust and tunable synthetic gene oscillator. Nature 456, 516-519 (2008). This study illustrates the maturity of synthetic biology; it reports the creation of a robust and tunable synthetic gene oscillator in E. coli.
    • Stricker, J. et al. A fast, robust and tunable synthetic gene oscillator. Nature 456, 516-519 (2008). This study illustrates the maturity of synthetic biology; it reports the creation of a robust and tunable synthetic gene oscillator in E. coli.
  • 24
    • 0036790975 scopus 로고    scopus 로고
    • Intrinsic and extrinsic contributions to stochasticity in gene expression
    • Swain, P. S., Elowitz, M. B. & Siggia, E. D. Intrinsic and extrinsic contributions to stochasticity in gene expression. Proc. Natl Acad. Sci. USA 99, 12795-12800 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 12795-12800
    • Swain, P.S.1    Elowitz, M.B.2    Siggia, E.D.3
  • 25
    • 64749116742 scopus 로고    scopus 로고
    • Using movies to analyse gene circuit dynamics in single cells
    • Locke, J. C. & Elowitz, M. B. Using movies to analyse gene circuit dynamics in single cells. Nature Rev. Microbiol. 7, 383-392 (2009).
    • (2009) Nature Rev. Microbiol , vol.7 , pp. 383-392
    • Locke, J.C.1    Elowitz, M.B.2
  • 26
    • 31844449923 scopus 로고    scopus 로고
    • Gene network shaping of inherent noise spectra
    • Austin, D. W. et al. Gene network shaping of inherent noise spectra. Nature 439, 608-611 (2006).
    • (2006) Nature , vol.439 , pp. 608-611
    • Austin, D.W.1
  • 27
    • 0037447260 scopus 로고    scopus 로고
    • Frequency domain analysis of noise in autoregulated gene circuits
    • Simpson, M. L., Cox, C. D. & Sayler, G. S. Frequency domain analysis of noise in autoregulated gene circuits. Proc. Natl Acad. Sci. USA 100, 4551-4556 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 4551-4556
    • Simpson, M.L.1    Cox, C.D.2    Sayler, G.S.3
  • 28
    • 0028832822 scopus 로고
    • Understanding, improving and using green fluorescent proteins
    • Cubitt, A. B. et al. Understanding, improving and using green fluorescent proteins. Trends Biochem. Sci. 20, 448-455 (1995).
    • (1995) Trends Biochem. Sci , vol.20 , pp. 448-455
    • Cubitt, A.B.1
  • 29
    • 0036138908 scopus 로고    scopus 로고
    • A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications
    • Nagai, T. et al. A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nature Biotech. 20, 87-90 (2002).
    • (2002) Nature Biotech , vol.20 , pp. 87-90
    • Nagai, T.1
  • 30
    • 0022971952 scopus 로고
    • Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis
    • Rogers, S., Wells, R. & Rechsteiner, M. Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science 234, 364-368 (1986).
    • (1986) Science , vol.234 , pp. 364-368
    • Rogers, S.1    Wells, R.2    Rechsteiner, M.3
  • 31
    • 0031746834 scopus 로고    scopus 로고
    • New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria
    • Andersen, J. B. et al. New unstable variants of green fluorescent protein for studies of transient gene expression in bacteria. Appl. Environ. Microbiol. 64, 2240-2246 (1998).
    • (1998) Appl. Environ. Microbiol , vol.64 , pp. 2240-2246
    • Andersen, J.B.1
  • 32
    • 34547607675 scopus 로고    scopus 로고
    • A synthetic gene network for tuning protein degradation in Saccharomyces cerevisiae
    • Grilly, C., Stricker, J., Pang, W. L., Bennett, M. R. & Hasty, J. A synthetic gene network for tuning protein degradation in Saccharomyces cerevisiae. Mol. Syst. Biol. 3, 127 (2007).
    • (2007) Mol. Syst. Biol , vol.3 , pp. 127
    • Grilly, C.1    Stricker, J.2    Pang, W.L.3    Bennett, M.R.4    Hasty, J.5
  • 33
    • 44849085110 scopus 로고    scopus 로고
    • A microfluidic device for temporally controlled gene expression and long-term fluorescent imaging in unperturbed dividing yeast cells
    • Charvin, G., Cross, F. R. & Siggia, E. D. A microfluidic device for temporally controlled gene expression and long-term fluorescent imaging in unperturbed dividing yeast cells. PLoS ONE 3, e1468 (2008).
    • (2008) PLoS ONE , vol.3
    • Charvin, G.1    Cross, F.R.2    Siggia, E.D.3
  • 34
    • 0034235973 scopus 로고    scopus 로고
    • Integrated system for rapid PCR-based DNA analysis in microfluidic devices
    • Khandurina, J. et al. Integrated system for rapid PCR-based DNA analysis in microfluidic devices. Anal. Chem. 72, 2995-3000 (2000).
    • (2000) Anal. Chem , vol.72 , pp. 2995-3000
    • Khandurina, J.1
  • 35
    • 0034213023 scopus 로고    scopus 로고
    • Chip-based microsystems for genomic and proteomic analysis
    • Sanders, G. H. W. & Manz, A. Chip-based microsystems for genomic and proteomic analysis. Trends Analyt. Chem. 19, 364-378 (2000).
    • (2000) Trends Analyt. Chem , vol.19 , pp. 364-378
    • Sanders, G.H.W.1    Manz, A.2
  • 36
    • 0035253329 scopus 로고    scopus 로고
    • Single-molecule DNA amplification and analysis in an integrated microfluidic device
    • Lagally, E. T., Medintz, I. & Mathies, R. A. Single-molecule DNA amplification and analysis in an integrated microfluidic device. Anal. Chem. 73, 565-570 (2001).
    • (2001) Anal. Chem , vol.73 , pp. 565-570
    • Lagally, E.T.1    Medintz, I.2    Mathies, R.A.3
  • 37
    • 0043064054 scopus 로고    scopus 로고
    • High-efficiency, two-dimensional separations of protein digests on microfluidic devices
    • Ramsey, J. D., Jacobson, S. C., Culbertson, C. T. & Ramsey, J. M. High-efficiency, two-dimensional separations of protein digests on microfluidic devices. Anal. Chem. 75, 3758-3764 (2003).
    • (2003) Anal. Chem , vol.75 , pp. 3758-3764
    • Ramsey, J.D.1    Jacobson, S.C.2    Culbertson, C.T.3    Ramsey, J.M.4
  • 38
    • 0242385640 scopus 로고    scopus 로고
    • Microfluidic devices for the high-throughput chemical analysis of cells
    • McClain, M. A. et al. Microfluidic devices for the high-throughput chemical analysis of cells. Anal. Chem. 75, 5646-5655 (2003).
    • (2003) Anal. Chem , vol.75 , pp. 5646-5655
    • McClain, M.A.1
  • 39
    • 0141653940 scopus 로고    scopus 로고
    • Integrated nanoliter systems
    • This review discusses the use of microfluidic devices for high-throughput biochemical assays
    • Hong, J. W. & Quake, S. R. Integrated nanoliter systems. Nature Biotechnol. 21, 1179-1183 (2003). This review discusses the use of microfluidic devices for high-throughput biochemical assays.
    • (2003) Nature Biotechnol , vol.21 , pp. 1179-1183
    • Hong, J.W.1    Quake, S.R.2
  • 40
    • 0034662160 scopus 로고    scopus 로고
    • Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping
    • Anderson, J. R. et al. Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping. Anal. Chem. 72, 3158-3164 (2000).
    • (2000) Anal. Chem , vol.72 , pp. 3158-3164
    • Anderson, J.R.1
  • 41
    • 0035853119 scopus 로고    scopus 로고
    • Using three-dimensional microfluidic networks for solving computationally hard problems
    • Chiu, D. T., Pezzoli, E., Wu, H., Stroock, A. D. & Whitesides, G. M. Using three-dimensional microfluidic networks for solving computationally hard problems. Proc. Natl Acad. Sci. USA 98, 2961-2966 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 2961-2966
    • Chiu, D.T.1    Pezzoli, E.2    Wu, H.3    Stroock, A.D.4    Whitesides, G.M.5
  • 42
    • 0037131390 scopus 로고    scopus 로고
    • Microfluidic large-scale integration
    • Thorsen, T., Maerkl, S. J. & Quake, S. R. Microfluidic large-scale integration. Science 298, 580-584 (2002).
    • (2002) Science , vol.298 , pp. 580-584
    • Thorsen, T.1    Maerkl, S.J.2    Quake, S.R.3
  • 43
    • 21644441288 scopus 로고    scopus 로고
    • Long-term monitoring of bacteria undergoing programmed population control in a microchemostat
    • Balagaddé, F. K., You, L., Hansen, C. L., Arnold, F. H. & Quake, S. R. Long-term monitoring of bacteria undergoing programmed population control in a microchemostat. Science 309, 137-140 (2005).
    • (2005) Science , vol.309 , pp. 137-140
    • Balagaddé, F.K.1    You, L.2    Hansen, C.L.3    Arnold, F.H.4    Quake, S.R.5
  • 44
    • 33646575914 scopus 로고    scopus 로고
    • Microfluidic single-cell mRNA isolation and analysis
    • Marcus, J. S., Anderson, W. F. & Quake, S. R. Microfluidic single-cell mRNA isolation and analysis. Anal. Chem. 78, 3084-3089 (2006).
    • (2006) Anal. Chem , vol.78 , pp. 3084-3089
    • Marcus, J.S.1    Anderson, W.F.2    Quake, S.R.3
  • 45
    • 33846467150 scopus 로고    scopus 로고
    • A systems approach to measuring the binding energy landscapes of transcription factors
    • Maerkl, S. J. & Quake, S. R. A systems approach to measuring the binding energy landscapes of transcription factors. Science 315, 233-237 (2007).
    • (2007) Science , vol.315 , pp. 233-237
    • Maerkl, S.J.1    Quake, S.R.2
  • 47
    • 0031569477 scopus 로고    scopus 로고
    • Transport, manipulation, and reaction of biological cells on-chip using electrokinetic effects
    • Li, P. C. H. & Harrison, D. J. Transport, manipulation, and reaction of biological cells on-chip using electrokinetic effects. Anal. Chem. 69, 1564-1568 (1997).
    • (1997) Anal. Chem , vol.69 , pp. 1564-1568
    • Li, P.C.H.1    Harrison, D.J.2
  • 49
    • 9144243610 scopus 로고    scopus 로고
    • NanoLiterBioReactor: Long-term mammalian cell culture at nanofabricated scale
    • Prokop, A. et al. NanoLiterBioReactor: long-term mammalian cell culture at nanofabricated scale. Biomed. Microdevices 6, 325-339 (2004).
    • (2004) Biomed. Microdevices , vol.6 , pp. 325-339
    • Prokop, A.1
  • 50
    • 24044453695 scopus 로고    scopus 로고
    • A microfluidic chemostat for experiments with bacterial and yeast cells
    • Groisman, A. et al. A microfluidic chemostat for experiments with bacterial and yeast cells. Nature Methods 2, 685-689 (2005).
    • (2005) Nature Methods , vol.2 , pp. 685-689
    • Groisman, A.1
  • 51
    • 33746868344 scopus 로고    scopus 로고
    • Cookson, S., Ostroff, N., Pang, W. L., Volfson, D. & Hasty, J. Monitoring dynamics of single-cell gene expression over multiple cell cycles. Mol. Syst. Biol. 1, 2005.0024 (2005).
    • Cookson, S., Ostroff, N., Pang, W. L., Volfson, D. & Hasty, J. Monitoring dynamics of single-cell gene expression over multiple cell cycles. Mol. Syst. Biol. 1, 2005.0024 (2005).
  • 52
    • 33751569377 scopus 로고    scopus 로고
    • Microfluidics device for single cell gene expression analysis in Saccharomyces cerevisiae
    • Ryley, J. & Pereira-Smith, O. M. Microfluidics device for single cell gene expression analysis in Saccharomyces cerevisiae. Yeast 23, 1065-1073 (2006).
    • (2006) Yeast , vol.23 , pp. 1065-1073
    • Ryley, J.1    Pereira-Smith, O.M.2
  • 53
    • 33645027986 scopus 로고    scopus 로고
    • Stochastic protein expression in individual cells at the single molecule level
    • Cai, L., Friedman, N. & Xie, X. S. Stochastic protein expression in individual cells at the single molecule level. Nature 440, 358-362 (2006).
    • (2006) Nature , vol.440 , pp. 358-362
    • Cai, L.1    Friedman, N.2    Xie, X.S.3
  • 54
    • 33746263955 scopus 로고    scopus 로고
    • Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays
    • Di Carlo, D., Aghdam, N. & Lee, L. P. Single-cell enzyme concentrations, kinetics, and inhibition analysis using high-density hydrodynamic cell isolation arrays. Anal. Chem. 78, 4925-4930 (2006).
    • (2006) Anal. Chem , vol.78 , pp. 4925-4930
    • Di Carlo, D.1    Aghdam, N.2    Lee, L.P.3
  • 55
    • 0034293766 scopus 로고    scopus 로고
    • Jeon, N. L. et al. Generation of solution and surface gradients using microfluidic systems. Langmuir 16, 8311-8316 (2000). This was one of the first investigations to use a microfluidic device capable of generating spatial chemical gradients to study a biological phenomenon.
    • Jeon, N. L. et al. Generation of solution and surface gradients using microfluidic systems. Langmuir 16, 8311-8316 (2000). This was one of the first investigations to use a microfluidic device capable of generating spatial chemical gradients to study a biological phenomenon.
  • 56
    • 0035866594 scopus 로고    scopus 로고
    • Generation of gradients having complex shapes using microfluidic networks
    • Dertinger, S. K. W., Chiu, D. T., Jeon, N. L. & Whitesides, G. M. Generation of gradients having complex shapes using microfluidic networks. Anal. Chem. 73, 1240-1246 (2001).
    • (2001) Anal. Chem , vol.73 , pp. 1240-1246
    • Dertinger, S.K.W.1    Chiu, D.T.2    Jeon, N.L.3    Whitesides, G.M.4
  • 57
    • 0036022527 scopus 로고    scopus 로고
    • Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device
    • Jeon, N. L. et al. Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nature Biotech. 20, 826-830 (2002).
    • (2002) Nature Biotech , vol.20 , pp. 826-830
    • Jeon, N.L.1
  • 58
    • 38549084632 scopus 로고    scopus 로고
    • The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae
    • Mettetal, J. T., Muzzey, D., Gomez-Uribe, C. & van Oudenaarden, A. The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae. Science 319, 482-484 (2008).
    • (2008) Science , vol.319 , pp. 482-484
    • Mettetal, J.T.1    Muzzey, D.2    Gomez-Uribe, C.3    van Oudenaarden, A.4
  • 60
    • 50649120833 scopus 로고    scopus 로고
    • Metabolic gene regulation in a dynamically changing environment
    • References 33 and 58-60 are seminal studies that used microfluidic devices to create temporal changes in the growth medium to study dynamic biological phenomena
    • Bennett, M. R. et al. Metabolic gene regulation in a dynamically changing environment. Nature 454, 1119-1122 (2008). References 33 and 58-60 are seminal studies that used microfluidic devices to create temporal changes in the growth medium to study dynamic biological phenomena.
    • (2008) Nature , vol.454 , pp. 1119-1122
    • Bennett, M.R.1
  • 61
    • 50349085576 scopus 로고    scopus 로고
    • Tightly regulated and heritable division control in single bacterial cells
    • Siegal-Gaskins, D. & Crosson, S. Tightly regulated and heritable division control in single bacterial cells. Biophys. J. 95, 2063-2072 (2008).
    • (2008) Biophys. J , vol.95 , pp. 2063-2072
    • Siegal-Gaskins, D.1    Crosson, S.2
  • 62
    • 0038444010 scopus 로고    scopus 로고
    • Intracellular integration of synthetic nanostructures with viable cells for controlled biochemical manipulation
    • McKnight, T. E. et al. Intracellular integration of synthetic nanostructures with viable cells for controlled biochemical manipulation. Nanotechnology 14, 551-556 (2003).
    • (2003) Nanotechnology , vol.14 , pp. 551-556
    • McKnight, T.E.1
  • 64
    • 43149116340 scopus 로고    scopus 로고
    • Single-cell protein induction dynamics reveals a period of vulnerability to antibiotics in persister bacteria
    • Gefen, O., Gabay, C., Mumcuoglu, M., Engel, G. & Balaban, N. Q. Single-cell protein induction dynamics reveals a period of vulnerability to antibiotics in persister bacteria. Proc. Natl Acad. Sci. USA 105, 6145-6149 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 6145-6149
    • Gefen, O.1    Gabay, C.2    Mumcuoglu, M.3    Engel, G.4    Balaban, N.Q.5
  • 65
    • 0037231111 scopus 로고    scopus 로고
    • A microfluidic bioreactor based on hydrogel-entrapped E. coli: Cell viability, lysis, and intracellular enzyme reactions
    • Heo, J., Thomas, K. J., Seong, G. H. & Crooks, R. M. A microfluidic bioreactor based on hydrogel-entrapped E. coli: cell viability, lysis, and intracellular enzyme reactions. Anal. Chem. 75, 22-26 (2003).
    • (2003) Anal. Chem , vol.75 , pp. 22-26
    • Heo, J.1    Thomas, K.J.2    Seong, G.H.3    Crooks, R.M.4
  • 66
    • 33745504892 scopus 로고    scopus 로고
    • Microchemostat-microbial continuous culture in a polymer-based, instrumented microbioreactor
    • Zhang, Z. et al. Microchemostat-microbial continuous culture in a polymer-based, instrumented microbioreactor. Lab Chip 6, 906-913 (2006).
    • (2006) Lab Chip , vol.6 , pp. 906-913
    • Zhang, Z.1
  • 67
    • 4544263876 scopus 로고    scopus 로고
    • A three-dimensional flow control concept for single-cell experiments on a microchip. 1. Cell selection, cell retention, cell culture, cell balancing, and cell scanning
    • Peng, X. Y. & Li, P. C. A three-dimensional flow control concept for single-cell experiments on a microchip. 1. Cell selection, cell retention, cell culture, cell balancing, and cell scanning. Anal. Chem. 76, 5273-5281 (2004).
    • (2004) Anal. Chem , vol.76 , pp. 5273-5281
    • Peng, X.Y.1    Li, P.C.2
  • 68
    • 57449107381 scopus 로고    scopus 로고
    • Dropspots: A picoliter array in a microfluidic device
    • Schmitz, C. H. J., Rowat, A. C., Koster, S. & Weitz, D. A. Dropspots: a picoliter array in a microfluidic device. Lab Chip 9, 44-49 (2009).
    • (2009) Lab Chip , vol.9 , pp. 44-49
    • Schmitz, C.H.J.1    Rowat, A.C.2    Koster, S.3    Weitz, D.A.4
  • 69
    • 33746538295 scopus 로고    scopus 로고
    • Pumpless, selective docking of yeast cells inside a microfluidic channel induced by receding meniscus
    • Park, M. C., Hur, J. Y., Kwon, K. W., Park, S. H. & Suh, K. Y. Pumpless, selective docking of yeast cells inside a microfluidic channel induced by receding meniscus. Lab Chip 6, 988-994 (2006).
    • (2006) Lab Chip , vol.6 , pp. 988-994
    • Park, M.C.1    Hur, J.Y.2    Kwon, K.W.3    Park, S.H.4    Suh, K.Y.5
  • 70
    • 18144418528 scopus 로고    scopus 로고
    • Micro/nanofluidic device for single-cell-based assay
    • Yun, K. S. & Yoon, E. Micro/nanofluidic device for single-cell-based assay. Biomed. Microdevices 7, 35-40 (2005).
    • (2005) Biomed. Microdevices , vol.7 , pp. 35-40
    • Yun, K.S.1    Yoon, E.2
  • 71
    • 0242586122 scopus 로고    scopus 로고
    • Microfluidic device for single-cell analysis
    • Wheeler, A. R. et al. Microfluidic device for single-cell analysis. Anal. Chem. 75, 3581-3586 (2003).
    • (2003) Anal. Chem , vol.75 , pp. 3581-3586
    • Wheeler, A.R.1
  • 72
    • 3242664287 scopus 로고    scopus 로고
    • Dynamic gene expression profiling using a microfabricated living cell array
    • Thompson, D. M. et al. Dynamic gene expression profiling using a microfabricated living cell array. Anal. Chem. 76, 4098-4103 (2004).
    • (2004) Anal. Chem , vol.76 , pp. 4098-4103
    • Thompson, D.M.1
  • 73
    • 4544288097 scopus 로고    scopus 로고
    • Microfluidic shear devices for quantitative analysis of cell adhesion
    • Lu, H. et al. Microfluidic shear devices for quantitative analysis of cell adhesion. Anal. Chem. 76, 5257-5264 (2004).
    • (2004) Anal. Chem , vol.76 , pp. 5257-5264
    • Lu, H.1
  • 74
    • 33845761551 scopus 로고    scopus 로고
    • A high-throughput microfluidic real-time gene expression living cell array
    • King, K. R. et al. A high-throughput microfluidic real-time gene expression living cell array. Lab Chip 7, 77-85 (2007).
    • (2007) Lab Chip , vol.7 , pp. 77-85
    • King, K.R.1
  • 76
    • 37249092455 scopus 로고    scopus 로고
    • Self-organization in high-density bacterial colonies: Efficient crowd control
    • Cho, H. et al. Self-organization in high-density bacterial colonies: efficient crowd control. PLoS Biol. 5, e302 (2007).
    • (2007) PLoS Biol , vol.5
    • Cho, H.1
  • 77
    • 44449091966 scopus 로고    scopus 로고
    • Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5
    • Hao, N. et al. Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol. Cell 30, 649-656 (2008).
    • (2008) Mol. Cell , vol.30 , pp. 649-656
    • Hao, N.1
  • 78
    • 0037165671 scopus 로고    scopus 로고
    • A microfluidic device with a linear temperature gradient for parallel and combinatorial measurements
    • Mao, H., Yang, T. & Cremer, P. S. A microfluidic device with a linear temperature gradient for parallel and combinatorial measurements. J. Am. Chem. Soc. 124, 4432-4435 (2002).
    • (2002) J. Am. Chem. Soc , vol.124 , pp. 4432-4435
    • Mao, H.1    Yang, T.2    Cremer, P.S.3
  • 80
    • 8844266899 scopus 로고    scopus 로고
    • Arrays of horizontally-oriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation
    • Zhu, X. et al. Arrays of horizontally-oriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation. Analyst 129, 1026-1031 (2004).
    • (2004) Analyst , vol.129 , pp. 1026-1031
    • Zhu, X.1
  • 81
    • 1342306789 scopus 로고    scopus 로고
    • Walker, G. M., Ozers, M. S. & Beebe, D. J. Cell infection within a microfluidic device using virus gradients. Sens. Actuators B Chem. 98, 347-355 (2004).
    • Walker, G. M., Ozers, M. S. & Beebe, D. J. Cell infection within a microfluidic device using virus gradients. Sens. Actuators B Chem. 98, 347-355 (2004).
  • 82
    • 17644388181 scopus 로고    scopus 로고
    • A general method for patterning gradients of biomolecules on surfaces using microfluidic networks
    • Jiang, X. et al. A general method for patterning gradients of biomolecules on surfaces using microfluidic networks. Anal. Chem. 77, 2338-2347 (2005).
    • (2005) Anal. Chem , vol.77 , pp. 2338-2347
    • Jiang, X.1
  • 83
    • 33646746703 scopus 로고    scopus 로고
    • Universal microfluidic gradient generator
    • Irimia, D., Geba, D. A. & Toner, M. Universal microfluidic gradient generator. Anal. Chem. 78, 3472-3477 (2006).
    • (2006) Anal. Chem , vol.78 , pp. 3472-3477
    • Irimia, D.1    Geba, D.A.2    Toner, M.3
  • 84
    • 0037965621 scopus 로고    scopus 로고
    • A sensitive, versatile microfluidic assay for bacterial chemotaxis
    • Mao, H., Cremer, P. S. & Manson, M. D. A sensitive, versatile microfluidic assay for bacterial chemotaxis. Proc. Natl Acad. Sci. USA 100, 5449-5454 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 5449-5454
    • Mao, H.1    Cremer, P.S.2    Manson, M.D.3
  • 85
    • 33644661720 scopus 로고    scopus 로고
    • A three-channel microfluidic device for generating static linear gradients and its application to the quantitative analysis of bacterial chemotaxis
    • Diao, J. et al. A three-channel microfluidic device for generating static linear gradients and its application to the quantitative analysis of bacterial chemotaxis. Lab Chip 6, 381-388 (2006).
    • (2006) Lab Chip , vol.6 , pp. 381-388
    • Diao, J.1
  • 86
    • 33750476278 scopus 로고    scopus 로고
    • T cell chemotaxis in a simple microfluidic device
    • Lin, F. & Butcher, E. C. T cell chemotaxis in a simple microfluidic device. Lab Chip 6, 1462-1469 (2006).
    • (2006) Lab Chip , vol.6 , pp. 1462-1469
    • Lin, F.1    Butcher, E.C.2
  • 87
    • 17144398875 scopus 로고    scopus 로고
    • Human neural stem cell growth and differentiation in a gradient-generating microfluidic device
    • Chung, B. G. et al. Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab Chip 5, 401-406 (2005).
    • (2005) Lab Chip , vol.5 , pp. 401-406
    • Chung, B.G.1
  • 88
    • 33847394655 scopus 로고    scopus 로고
    • MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast
    • Paliwal, S. et al. MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature 446, 46-51 (2007).
    • (2007) Nature , vol.446 , pp. 46-51
    • Paliwal, S.1
  • 89
    • 3142694728 scopus 로고    scopus 로고
    • Generation of dynamic temporal and spatial concentration gradients using microfluidic devices
    • Lin, F. et al. Generation of dynamic temporal and spatial concentration gradients using microfluidic devices. Lab Chip 4, 164-167 (2004).
    • (2004) Lab Chip , vol.4 , pp. 164-167
    • Lin, F.1
  • 90
    • 33645383666 scopus 로고    scopus 로고
    • Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients
    • Irimia, D. et al. Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. Lab Chip 6, 191-198 (2006).
    • (2006) Lab Chip , vol.6 , pp. 191-198
    • Irimia, D.1
  • 91
    • 50649111625 scopus 로고    scopus 로고
    • Systems biology - reverse engineering the cell
    • Ingolia, N. T. & Weissman, J. S. Systems biology - reverse engineering the cell. Nature 454, 1059-1062 (2008).
    • (2008) Nature , vol.454 , pp. 1059-1062
    • Ingolia, N.T.1    Weissman, J.S.2
  • 92
    • 12344282703 scopus 로고    scopus 로고
    • Differentiation-on-a- chip: A microfluidic platform for long-term cell culture studies
    • Tourovskaia, A., Figueroa-Masot, X. & Folch, A. Differentiation-on-a- chip: a microfluidic platform for long-term cell culture studies. Lab Chip 5, 14-19 (2005).
    • (2005) Lab Chip , vol.5 , pp. 14-19
    • Tourovskaia, A.1    Figueroa-Masot, X.2    Folch, A.3
  • 93
    • 20444420895 scopus 로고    scopus 로고
    • A chemical waveform synthesizer
    • Olofsson, J. et al. A chemical waveform synthesizer. Proc. Natl Acad. Sci. USA 102, 8097-8102 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 8097-8102
    • Olofsson, J.1
  • 94
    • 57449118900 scopus 로고    scopus 로고
    • Dynamic cell culture: A microfluidic function generator for live cell microscopy
    • Lee, P. J., Gaige, T. A. & Hung, P. J. Dynamic cell culture: a microfluidic function generator for live cell microscopy. Lab Chip 9, 164-166 (2009).
    • (2009) Lab Chip , vol.9 , pp. 164-166
    • Lee, P.J.1    Gaige, T.A.2    Hung, P.J.3
  • 95
    • 61449096586 scopus 로고    scopus 로고
    • Microfluidic perfusion system for automated delivery of temporal gradients to islets of Langerhans
    • Zhang, X. & Roper, M. G. Microfluidic perfusion system for automated delivery of temporal gradients to islets of Langerhans. Anal. Chem. 81, 1162-1168 (2009).
    • (2009) Anal. Chem , vol.81 , pp. 1162-1168
    • Zhang, X.1    Roper, M.G.2
  • 96
    • 66149084862 scopus 로고    scopus 로고
    • Forced periodic expression of G1 cyclins phase-locks the budding yeast cell cycle
    • Charvin, G., Cross, F. R. & Siggia, E. D. Forced periodic expression of G1 cyclins phase-locks the budding yeast cell cycle. Proc. Natl Acad. Sci. USA 106, 6632-6637 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 6632-6637
    • Charvin, G.1    Cross, F.R.2    Siggia, E.D.3
  • 97
    • 55949131242 scopus 로고    scopus 로고
    • The chemistrode: A droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution
    • Chen, D. et al. The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proc. Natl Acad. Sci. USA 105, 16843-16848 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 16843-16848
    • Chen, D.1
  • 98
    • 37349067768 scopus 로고    scopus 로고
    • Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments
    • King, K. R., Wang, S., Jayaraman, A., Yarmush, M. L. & Toner, M. Microfluidic flow-encoded switching for parallel control of dynamic cellular microenvironments. Lab Chip 8, 107-116 (2008).
    • (2008) Lab Chip , vol.8 , pp. 107-116
    • King, K.R.1    Wang, S.2    Jayaraman, A.3    Yarmush, M.L.4    Toner, M.5
  • 99
    • 62649094918 scopus 로고    scopus 로고
    • Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform
    • Taylor, R. J. et al. Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform. Proc. Natl Acad. Sci. USA 106, 3758-3763 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3758-3763
    • Taylor, R.J.1
  • 101
    • 64649103179 scopus 로고    scopus 로고
    • Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures
    • Polinkovsky, M., Gutierrez, E., Levchenko, A. & Groisman, A. Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures. Lab Chip 9, 1073-1084 (2009).
    • (2009) Lab Chip , vol.9 , pp. 1073-1084
    • Polinkovsky, M.1    Gutierrez, E.2    Levchenko, A.3    Groisman, A.4
  • 102
    • 33645522086 scopus 로고    scopus 로고
    • Microfluidics-based systems biology
    • Breslauer, D. N., Lee, P. J. & Lee, L. P. Microfluidics-based systems biology. Mol. Biosyst. 2, 97-112 (2006).
    • (2006) Mol. Biosyst , vol.2 , pp. 97-112
    • Breslauer, D.N.1    Lee, P.J.2    Lee, L.P.3
  • 103
    • 57449090900 scopus 로고    scopus 로고
    • Defined spatial structure stabilizes a synthetic multispecies bacterial community
    • Kim, H. J., Boedicker, J. Q., Choi, J. W. & Ismagilov, R. F. Defined spatial structure stabilizes a synthetic multispecies bacterial community. Proc. Natl Acad. Sci. USA 105, 18188-18193 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 18188-18193
    • Kim, H.J.1    Boedicker, J.Q.2    Choi, J.W.3    Ismagilov, R.F.4
  • 107
    • 17844376743 scopus 로고    scopus 로고
    • Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics
    • Lucchetta, E. M., Lee, J. H., Fu, L. A., Patel, N. H. & Ismagilov, R. F. Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics. Nature 434, 1134-1138 (2005).
    • (2005) Nature , vol.434 , pp. 1134-1138
    • Lucchetta, E.M.1    Lee, J.H.2    Fu, L.A.3    Patel, N.H.4    Ismagilov, R.F.5
  • 108
    • 52949098296 scopus 로고    scopus 로고
    • Frequency-modulated nuclear localization bursts coordinate gene regulation
    • Cai, L., Dalal, C. K. & Elowitz, M. B. Frequency-modulated nuclear localization bursts coordinate gene regulation. Nature 455, 485-490 (2008).
    • (2008) Nature , vol.455 , pp. 485-490
    • Cai, L.1    Dalal, C.K.2    Elowitz, M.B.3
  • 109
    • 0036207347 scopus 로고    scopus 로고
    • Modeling and simulation of genetic regulatory systems: A literature review
    • De Jong, H. Modeling and simulation of genetic regulatory systems: a literature review. J. Comput. Biol. 9, 67-103 (2002).
    • (2002) J. Comput. Biol , vol.9 , pp. 67-103
    • De Jong, H.1
  • 110
    • 0015609281 scopus 로고
    • The logical analysis of continuous, non-linear biochemical control networks
    • Glass, L. & Kauffman, S. A. The logical analysis of continuous, non-linear biochemical control networks. J. Theor. Biol. 39, 103-129 (1973).
    • (1973) J. Theor. Biol , vol.39 , pp. 103-129
    • Glass, L.1    Kauffman, S.A.2
  • 111
    • 0016145568 scopus 로고
    • Comparison of classical and autogenous systems of regulation in inducible operons
    • Savageau, M. A. Comparison of classical and autogenous systems of regulation in inducible operons. Nature 252, 546-549 (1974).
    • (1974) Nature , vol.252 , pp. 546-549
    • Savageau, M.A.1
  • 112
    • 61349161146 scopus 로고    scopus 로고
    • Delay-induced degrade-and-fire oscillations in small genetic circuits
    • Mather, W., Bennett, M. R., Hasty, J. & Tsimring, L. S. Delay-induced degrade-and-fire oscillations in small genetic circuits. Phys. Rev. Lett. 102, 068105 (2009).
    • (2009) Phys. Rev. Lett , vol.102 , pp. 068105
    • Mather, W.1    Bennett, M.R.2    Hasty, J.3    Tsimring, L.S.4
  • 113
    • 58749106454 scopus 로고    scopus 로고
    • Ensemble modeling of metabolic networks
    • Tran, L. M., Rizk, M. L. & Liao, J. C. Ensemble modeling of metabolic networks. Biophys. J. 95, 5606-5617 (2008).
    • (2008) Biophys. J , vol.95 , pp. 5606-5617
    • Tran, L.M.1    Rizk, M.L.2    Liao, J.C.3
  • 114
    • 0035193294 scopus 로고    scopus 로고
    • Stochasticity in transcriptional regulation: Origins, consequences, and mathematical representations
    • References 109-111 and 114 discuss some of the best modelling techniques that are common to both systems and synthetic biology, especially those that model the dynamics and stochasticity of gene regulation
    • Kepler, T. B. & Elston, T. C. Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations. Biophys. J. 81, 3116-3136 (2001). References 109-111 and 114 discuss some of the best modelling techniques that are common to both systems and synthetic biology, especially those that model the dynamics and stochasticity of gene regulation.
    • (2001) Biophys. J , vol.81 , pp. 3116-3136
    • Kepler, T.B.1    Elston, T.C.2
  • 116
    • 54249099099 scopus 로고    scopus 로고
    • Zamir, E. & Bastiaens, P. I. Reverse engineering intracellular biochemical networks. Nature Chem. Biol. 4, 643-647 (2008).
    • Zamir, E. & Bastiaens, P. I. Reverse engineering intracellular biochemical networks. Nature Chem. Biol. 4, 643-647 (2008).
  • 117
    • 0006092502 scopus 로고    scopus 로고
    • Designer gene networks: Towards fundamental cellular control
    • Hasty, J., Isaacs, F., Dolnik, M., McMillen, D. & Collins, J. J. Designer gene networks: towards fundamental cellular control. Chaos 11, 207-220 (2001).
    • (2001) Chaos , vol.11 , pp. 207-220
    • Hasty, J.1    Isaacs, F.2    Dolnik, M.3    McMillen, D.4    Collins, J.J.5
  • 118
    • 0037444724 scopus 로고    scopus 로고
    • Stochastic chemical kinetics and the quasi-steady-state assumption: Application to the Gillespie algorithm
    • Rao, C. V. & Arkin, A. P. Stochastic chemical kinetics and the quasi-steady-state assumption: application to the Gillespie algorithm. J. Chem. Phys. 118, 4999-5010 (2003).
    • (2003) J. Chem. Phys , vol.118 , pp. 4999-5010
    • Rao, C.V.1    Arkin, A.P.2
  • 119
    • 33645429016 scopus 로고
    • Exact stochastic simulation of coupled chemical-reactions
    • This paper describes the Gillespie algorithm, which is used to simulate systems of randomly interacting chemical species and is now ubiquitously used in the synthetic biology community
    • Gillespie, D. T. Exact stochastic simulation of coupled chemical-reactions. J. Phys. Chem. 81, 2340-2361 (1977). This paper describes the Gillespie algorithm, which is used to simulate systems of randomly interacting chemical species and is now ubiquitously used in the synthetic biology community.
    • (1977) J. Phys. Chem , vol.81 , pp. 2340-2361
    • Gillespie, D.T.1
  • 120
    • 32844454497 scopus 로고    scopus 로고
    • Origins of extrinsic variability in eukaryotic gene expression
    • Volfson, D. et al. Origins of extrinsic variability in eukaryotic gene expression. Nature 439, 861-864 (2006).
    • (2006) Nature , vol.439 , pp. 861-864
    • Volfson, D.1
  • 121
    • 0017391683 scopus 로고
    • Time lag in a model of a biochemical reaction sequence with end product inhibition
    • MacDonald, N. Time lag in a model of a biochemical reaction sequence with end product inhibition. J. Theor. Biol. 67, 549-556 (1977).
    • (1977) J. Theor. Biol , vol.67 , pp. 549-556
    • MacDonald, N.1
  • 122
    • 0021171678 scopus 로고
    • Models of genetic control by repression with time delays and spatial effects
    • Mahaffy, J. M. & Pao, C. V. Models of genetic control by repression with time delays and spatial effects. J. Math. Biol. 20, 39-57 (1984).
    • (1984) J. Math. Biol , vol.20 , pp. 39-57
    • Mahaffy, J.M.1    Pao, C.V.2
  • 123
    • 0029028963 scopus 로고
    • Circuit simulation of genetic networks
    • McAdams, H. H. & Shapiro, L. Circuit simulation of genetic networks. Science 269, 650-656 (1995).
    • (1995) Science , vol.269 , pp. 650-656
    • McAdams, H.H.1    Shapiro, L.2
  • 125
    • 0037339442 scopus 로고    scopus 로고
    • Fluctuations and slow variables in genetic networks
    • Bundschuh, R., Hayot, F. & Jayaprakash, C. Fluctuations and slow variables in genetic networks. Biophys. J. 84, 1606-1615 (2003).
    • (2003) Biophys. J , vol.84 , pp. 1606-1615
    • Bundschuh, R.1    Hayot, F.2    Jayaprakash, C.3
  • 126
    • 34247849391 scopus 로고    scopus 로고
    • Transient dynamics of genetic regulatory networks
    • Bennett, M. R., Volfson, D., Tsimring, L. & Hasty, J. Transient dynamics of genetic regulatory networks. Biophys. J. 92, 3501-3512 (2007).
    • (2007) Biophys. J , vol.92 , pp. 3501-3512
    • Bennett, M.R.1    Volfson, D.2    Tsimring, L.3    Hasty, J.4
  • 127
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • Gardner, T. S., Cantor, C. R. & Collins, J. J. Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339-342 (2000).
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 128
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • References 127 and 128 are two of the earliest triumphs of synthetic biology, the construction of a genetic toggle switch and a synthetic oscillator, respectively
    • Elowitz, M. B. & Leibler, S. A synthetic oscillatory network of transcriptional regulators. Nature 403, 335-338 (2000). References 127 and 128 are two of the earliest triumphs of synthetic biology, the construction of a genetic toggle switch and a synthetic oscillator, respectively.
    • (2000) Nature , vol.403 , pp. 335-338
    • Elowitz, M.B.1    Leibler, S.2


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