Regulation of Cell Signaling Dynamics by the Protein Kinase-Scaffold Ste5

Molecular Cell

Volumn 30, Issue 5, 2008, Pages 649-656

  Hao, Nan ^a   Nayak, Sujata ^c   Behar, Marcelo ^b   Shanks, Ryan H ^a   Nagiec, Michal J ^a   Errede, Beverly ^a   Hasty, Jeffrey ^c   Elston, Timothy C ^a   Dohlman, Henrik G ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

SIGNALING

Indexed keywords

FUS3 ENZYME; KSS1 ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; PHEROMONE; PROTEIN KINASE; PROTEIN STE5; SCAFFOLD PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL DIVISION; CELL ELONGATION; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE CONTROL; NONHUMAN; PROTEIN BINDING; SIGNAL TRANSDUCTION; YEAST CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL DIFFERENTIATION; ENZYME ACTIVATION; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; PHEROMONES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 44449091966     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2008.04.016     Document Type: Article

References (31)

1. Andersson J., Simpson D.M., Qi M., Wang Y., and Elion E.A. Differential input by Ste5 scaffold and Msg5 phosphatase route a MAPK cascade to multiple outcomes. EMBO J. 23 (2004) 2564-2576
2. Bhattacharyya R.P., Remenyi A., Good M.C., Bashor C.J., Falick A.M., and Lim W.A. The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway. Science 311 (2006) 822-826
3. Breitkreutz A., Boucher L., and Tyers M. MAPK specificity in the yeast pheromone response independent of transcriptional activation. Curr. Biol. 11 (2001) 1266-1271
4. Choi K.Y., Satterberg B., Lyons D.M., and Elion E.A. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 78 (1994) 499-512
5. Cook J.G., Bardwell L., and Thorner J. Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway. Nature 390 (1997) 85-88
6. Dorer R., Pryciak P.M., and Hartwell L.H. Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients. J. Cell Biol. 131 (1995) 845-861
7. Erdman S., and Snyder M. A filamentous growth response mediated by the yeast mating pathway. Genetics 159 (2001) 919-928
8. Ferrell J.E.J., and Machleder E.M. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science 280 (1998) 895-898
9. Flatauer L.J., Zadeh S.F., and Bardwell L. Mitogen-activated protein kinases with distinct requirements for Ste5 scaffolding influence signaling specificity in Saccharomyces cerevisiae. Mol. Cell. Biol. 25 (2005) 1793-1803
10. Gartner A., Nasmyth K., and Ammerer G. Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1. Genes Dev. 6 (1992) 1280-1292
11. Goldbeter A., and Koshland Jr. D.E. An amplified sensitivity arising from covalent modification in biological systems. Proc. Natl. Acad. Sci. USA 78 (1981) 6840-6844
12. Koshland Jr. D.E., Goldbeter A., and Stock J.B. Amplification and adaptation in regulatory and sensory systems. Science 217 (1982) 220-225
13. Kusari A.B., Molina D.M., Sabbagh Jr. W., Lau C.S., and Bardwell L. A conserved protein interaction network involving the yeast MAP kinases Fus3 and Kss1. J. Cell Biol. 164 (2004) 267-277
14. Liu H., Styles C.A., and Fink G.R. Elements of the yeast pheromone response pathway required for filamentous growth of diploids. Science 262 (1993) 1741-1744
15. Madden K., and Snyder M. Specification of sites for polarized growth in Saccharomyces cerevisiae and the influence of external factors on site selection. Mol. Biol. Cell 3 (1992) 1025-1035
16. Madhani H.D., and Fink G.R. Combinatorial control required for the specificity of yeast MAPK signaling. Science 275 (1997) 1314-1317
17. Maeder C.I., Hink M.A., Kinkhabwala A., Mayr R., Bastiaens P.I., and Knop M. Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling. Nat. Cell Biol. 9 (2007) 1319-1326
18. Maleri S., Ge Q., Hackett E.A., Wang Y., Dohlman H.G., and Errede B. Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast. Mol. Cell. Biol. 24 (2004) 9221-9238
19. Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80 (1995) 179-185
20. Nern A., and Arkowitz R.A. A GTP-exchange factor required for cell orientation. Nature 391 (1998) 195-198
21. Paliwal S., Iglesias P.A., Campbell K., Hilioti Z., Groisman A., and Levchenko A. MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature 446 (2007) 46-51
22. Poritz M.A., Malmstrom S., Kim M.K., Rossmeissl P.J., and Kamb A. Graded mode of transcriptional induction in yeast pheromone signalling revealed by single-cell analysis. Yeast 18 (2001) 1331-1338
23. Printen J.A., and Sprague Jr. G.F. Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138 (1994) 609-619
24. Roberts R.L., and Fink G.R. Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth. Genes Dev. 8 (1994) 2974-2985
25. Roberts C.J., Nelson B., Marton M.J., Stoughton R., Meyer M.R., Bennett H.A., He Y.D., Dai H., Walker W.L., Hughes T.R., et al. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287 (2000) 873-880
26. Sabbagh Jr. W., Flatauer L.J., Bardwell A.J., and Bardwell L. Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation. Mol. Cell 8 (2001) 683-691
27. Segall J.E. Polarization of yeast cells in spatial gradients of alpha mating factor. Proc. Natl. Acad. Sci. USA 90 (1993) 8332-8336
28. Sette C., Inouye C.J., Stroschein S.L., Iaquinta P.J., and Thorner J. Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the ste5 scaffold protein. Mol. Biol. Cell 11 (2000) 4033-4049
29. Strickfaden S.C., and Pryciak P.M. Distinct roles for two G{alpha}-G{beta} interfaces in cell polarity control by a yeast heterotrimeric G protein. Mol. Biol. Cell 19 (2007) 181-197
30. Valtz N., Peter M., and Herskowitz I. FAR1 is required for oriented polarization of yeast cells in response to mating pheromones. J. Cell Biol. 131 (1995) 863-873
31. Wang Y., and Dohlman H.G. Pheromone signaling mechanisms in yeast: a prototypical sex machine. Science 306 (2004) 1508-1509