Raman signatures of ligand binding and allosteric conformation change in hexameric insulin

Biopolymers - Biospectroscopy Section

Volumn 62, Issue 5, 2001, Pages 249-260

  Ferrari, Davide ^a   Diers, James R ^a   Bocian, David F ^b   Kaarsholm, Niels C ^c   Dunn, Michael F ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NOVO NORDISK A S   (Denmark)

Author keywords

Allostery; Insulin hexamer; Ligand binding; Raman difference spectra

Indexed keywords

AROMATIC COMPOUNDS; CONFORMATIONS; INSULIN; PROTEINS; RAMAN SCATTERING; SPECTROSCOPY;

PHENOLIC LIGANDS;

BIOPOLYMERS;

4 AMINOBENZOIC ACID; 4 HYDROXY 3 NITROBENZOIC ACID; AMIDE; ANION; AROMATIC COMPOUND; CARBOXYLIC ACID DERIVATIVE; HISTIDINE; INSULIN; METAL; NITROBENZOIC ACID DERIVATIVE; PHENOL DERIVATIVE; PHENYLALANINE; THIOCYANATE; UNCLASSIFIED DRUG;

ALLOSTERISM; ALPHA HELIX; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; HUMAN; LIGAND BINDING; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; RAMAN SPECTROMETRY;

ALLOSTERIC SITE; COBALT; HUMANS; INSULIN; LIGANDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SPECTRUM ANALYSIS, RAMAN; SUBSTRATE SPECIFICITY; ZINC;

EID: 0034795660     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.1020     Document Type: Article

References (38)