Binding of 2,6- and 2,7-dihydroxynaphthalene to wild-type and E-B13Q insulins: Dynamic, equilibrium, and molecular modeling investigations

Biochemistry

Volumn 36, Issue 42, 1997, Pages 12746-12758

  Bloom, Curtis R ^a,c   Heymann, Robert ^a   Kaarsholm, Niels C ^b   Dunn, Michael F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NOVO NORDISK A S   (Denmark)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; NAPHTHALENE DERIVATIVE; PHENOL DERIVATIVE; RECOMBINANT HUMAN INSULIN;

ABSORPTION SPECTROSCOPY; ARTICLE; BINDING AFFINITY; HORMONE BINDING; HUMAN; HYDROGEN BOND; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ALLOSTERIC SITE; COMPUTER SIMULATION; HUMANS; HYDROGEN BONDING; INSULIN; KINETICS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; NAPHTHOLS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY;

EID: 0030668277     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970761n     Document Type: Article

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