메뉴 건너뛰기




Volumn 11, Issue 4, 2009, Pages 383-393

Induced pluripotent stem cells: Will they be safe?

Author keywords

Cell therapy; Induced pluripotent stem cell; Malignant potential; Safety

Indexed keywords

ADENOVIRUS VECTOR; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR SOX2;

EID: 68649125560     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (21)

References (88)
  • 1
    • 33745632618 scopus 로고    scopus 로고
    • Nuclear reprogramming and pluripotency
    • Hochedlinger K, Jaenisch R: Nuclear reprogramming and pluripotency. Nature (2006) 441 (7097):1061-1067.
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1061-1067
    • Hochedlinger, K.1    Jaenisch, R.2
  • 2
    • 50149108172 scopus 로고    scopus 로고
    • The promise of human induced pluripotent stem cells for research and therapy
    • Nishikawa S, Goldstein RA, Nierras CR: The promise of human induced pluripotent stem cells for research and therapy. Nat Rev Mol Cell Biol (2008) 9(9):725-729.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.9 , pp. 725-729
    • Nishikawa, S.1    Goldstein, R.A.2    Nierras, C.R.3
  • 3
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 126(4):663-676.
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 4
    • 68649087539 scopus 로고    scopus 로고
    • Breakthrough article first describing the generation of iPS cells from mouse fibroblasts using four factors
    • Breakthrough article first describing the generation of iPS cells from mouse fibroblasts using four factors.
  • 6
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germlinecompetent induced pluripotent stem cells
    • Okita K, Ichisaka T, Yamanaka S: Generation of germlinecompetent induced pluripotent stem cells. Nature (2007) 448 (7151):313-317.
    • (2007) Nature , vol.448 , Issue.7151 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 7
    • 68649120584 scopus 로고    scopus 로고
    • Generation of the first germline-competent iPS cells is described. Tumors developed in 25% of chimeric mice.
    • Generation of the first germline-competent iPS cells is described. Tumors developed in 25% of chimeric mice.
  • 9
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 131(5):861-872.
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 10
    • 68649116416 scopus 로고    scopus 로고
    • First report of iPS cells generated from human somatic cells
    • First report of iPS cells generated from human somatic cells.
  • 13
    • 68649100106 scopus 로고    scopus 로고
    • First proof-of-concept study in which mice with sickle cell anemia were transplanted using iPS cells generated from autologous skin, genetically modified and differentiated into hematopoietic cells
    • First proof-of-concept study in which mice with sickle cell anemia were transplanted using iPS cells generated from autologous skin, genetically modified and differentiated into hematopoietic cells.
  • 15
    • 33646887376 scopus 로고    scopus 로고
    • Genotoxicity of retroviral integration in hematopoietic cells
    • Nienhuis AW, Dunbar CE, Sorrentino BP: Genotoxicity of retroviral integration in hematopoietic cells. Mol Ther (2006) 13(6): 1031-1049.
    • (2006) Mol Ther , vol.13 , Issue.6 , pp. 1031-1049
    • Nienhuis, A.W.1    Dunbar, C.E.2    Sorrentino, B.P.3
  • 16
    • 34249863603 scopus 로고    scopus 로고
    • Strategies and new developments in the generation of patient-specific pluripotent stem cells
    • Yamanaka S: Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell (2007) 1(1):39-49.
    • (2007) Cell Stem Cell , vol.1 , Issue.1 , pp. 39-49
    • Yamanaka, S.1
  • 17
    • 38049155833 scopus 로고    scopus 로고
    • Stem cells. A new year and a new era
    • Pera MF: Stem cells. A new year and a new era. Nature (2008) 451 (7175):135-136.
    • (2008) Nature , vol.451 , Issue.7175 , pp. 135-136
    • Pera, M.F.1
  • 18
    • 56549127713 scopus 로고    scopus 로고
    • Guidelines and techniques for the generation of induced pluripotent stem cells
    • Maherali N, Hochedlinger K: Guidelines and techniques for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 3(6):595-605.
    • (2008) Cell Stem Cell , vol.3 , Issue.6 , pp. 595-605
    • Maherali, N.1    Hochedlinger, K.2
  • 19
    • 68649121046 scopus 로고    scopus 로고
    • NIH, Bethesda, MD, USA
    • MEDLINE database: NIH, Bethesda, MD, USA (2009). www.pubmed.com
    • (2009) MEDLINE database
  • 20
    • 68649097727 scopus 로고    scopus 로고
    • Wiley, Hoboken, NJ, USA
    • Cochrane database: Wiley, Hoboken, NJ, USA (2009). www3.interscience.wiley.com
    • (2009) Cochrane database
  • 21
    • 68649107717 scopus 로고    scopus 로고
    • Elsevier, New York, NY, USA
    • EMBASE database: Elsevier, New York, NY, USA (2009). www.embase.com
    • (2009) EMBASE database
  • 23
    • 68649087048 scopus 로고    scopus 로고
    • First paper to demonstrate that IPS cells can be generated using Oct-4 only.
    • First paper to demonstrate that IPS cells can be generated using Oct-4 only.
  • 27
    • 68649117796 scopus 로고    scopus 로고
    • Described the generation of a panel of disease-specific iPS cell lines
    • Described the generation of a panel of disease-specific iPS cell lines.
  • 32
    • 45449094570 scopus 로고    scopus 로고
    • Reprogramming of pancreatic β cells into induced pluripotent stem cells
    • Stadtfeld M, Brennand K, Hochedlinger K: Reprogramming of pancreatic β cells into induced pluripotent stem cells. Curr Biol (2008) 18(12):890-894.
    • (2008) Curr Biol , vol.18 , Issue.12 , pp. 890-894
    • Stadtfeld, M.1    Brennand, K.2    Hochedlinger, K.3
  • 33
    • 55849115999 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated without viral integration
    • Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K: Induced pluripotent stem cells generated without viral integration. Science (2008) 322 (5903):945-949.
    • (2008) Science , vol.322 , Issue.5903 , pp. 945-949
    • Stadtfeld, M.1    Nagaya, M.2    Utikal, J.3    Weir, G.4    Hochedlinger, K.5
  • 34
    • 55049122748 scopus 로고    scopus 로고
    • Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression
    • Eminli S, Utikal J, Arnold K, Jaenisch R, Hochedlinger K: Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells (2008) 26(10):2467-2474.
    • (2008) Stem Cells , vol.26 , Issue.10 , pp. 2467-2474
    • Eminli, S.1    Utikal, J.2    Arnold, K.3    Jaenisch, R.4    Hochedlinger, K.5
  • 37
    • 18844392836 scopus 로고    scopus 로고
    • Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues
    • Hochedlinger K, Yamada Y, Beard C, Jaenisch R: Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 121(3):465-477.
    • (2005) Cell , vol.121 , Issue.3 , pp. 465-477
    • Hochedlinger, K.1    Yamada, Y.2    Beard, C.3    Jaenisch, R.4
  • 38
    • 0344063368 scopus 로고    scopus 로고
    • Oct-3/4 is a dosedependent oncogenic fate determinant
    • Gidekel S, Pizov G, Bergman Y, Pikarsky E: Oct-3/4 is a dosedependent oncogenic fate determinant. Cancer Cell (2003) 4(5):361-370.
    • (2003) Cancer Cell , vol.4 , Issue.5 , pp. 361-370
    • Gidekel, S.1    Pizov, G.2    Bergman, Y.3    Pikarsky, E.4
  • 39
    • 59849125058 scopus 로고    scopus 로고
    • Oct4A is expressed by a subpopulation of prostate neuroendocrine cells
    • Sotomayor P, Godoy A, Smith GJ, Huss WJ: Oct4A is expressed by a subpopulation of prostate neuroendocrine cells. Prostate (2009) 69(4):401-410.
    • (2009) Prostate , vol.69 , Issue.4 , pp. 401-410
    • Sotomayor, P.1    Godoy, A.2    Smith, G.J.3    Huss, W.J.4
  • 42
    • 0032572734 scopus 로고    scopus 로고
    • Generation of purified neural precursors from embryonic stem cells by lineage selection
    • Li M, Pevny L, Lovell-Badge R, Smith A: Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr Biol (1998) 8(17):971-974.
    • (1998) Curr Biol , vol.8 , Issue.17 , pp. 971-974
    • Li, M.1    Pevny, L.2    Lovell-Badge, R.3    Smith, A.4
  • 44
    • 34250315214 scopus 로고    scopus 로고
    • Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo
    • Gu G, Yuan J, Wills M, Kasper S: Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo. Cancer Res (2007) 67(10):4807-4815.
    • (2007) Cancer Res , vol.67 , Issue.10 , pp. 4807-4815
    • Gu, G.1    Yuan, J.2    Wills, M.3    Kasper, S.4
  • 46
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, Weinberg RA: An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 40(5):499-507.
    • (2008) Nat Genet , vol.40 , Issue.5 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6    Weinberg, R.A.7
  • 49
    • 30144440248 scopus 로고    scopus 로고
    • The Klf4 tumour suppressor is a transcriptional repressor of p53 that acts as a contextdependent oncogene
    • Rowland BD, Bernards R, Peeper DS: The Klf4 tumour suppressor is a transcriptional repressor of p53 that acts as a contextdependent oncogene. Nat Cell Biol (2005) 7(11):1074-1082.
    • (2005) Nat Cell Biol , vol.7 , Issue.11 , pp. 1074-1082
    • Rowland, B.D.1    Bernards, R.2    Peeper, D.S.3
  • 50
    • 13944273471 scopus 로고    scopus 로고
    • p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
    • Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E, Xu Y: p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol (2005) 7(2): 165-171.
    • (2005) Nat Cell Biol , vol.7 , Issue.2 , pp. 165-171
    • Lin, T.1    Chao, C.2    Saito, S.3    Mazur, S.J.4    Murphy, M.E.5    Appella, E.6    Xu, Y.7
  • 56
    • 37549008674 scopus 로고    scopus 로고
    • c-Myc is dispensable for direct reprogramming of mouse fibroblasts
    • Wernig M, Meissner A, Cassady JP, Jaenisch R: c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2008) 2(1):10-12.
    • (2008) Cell Stem Cell , vol.2 , Issue.1 , pp. 10-12
    • Wernig, M.1    Meissner, A.2    Cassady, J.P.3    Jaenisch, R.4
  • 57
    • 38049055931 scopus 로고    scopus 로고
    • Simpler and safer cell reprogramming
    • Pera MF, Hasegawa K: Simpler and safer cell reprogramming. Nat Biotechnol (2008) 26(1):59-60.
    • (2008) Nat Biotechnol , vol.26 , Issue.1 , pp. 59-60
    • Pera, M.F.1    Hasegawa, K.2
  • 58
    • 34548445454 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells in the absence of drug selection
    • Blelloch R, Venere M, Yen J, Ramalho-Santos M: Generation of induced pluripotent stem cells in the absence of drug selection. Cell Stem Cell (2007) 1(3):245-247.
    • (2007) Cell Stem Cell , vol.1 , Issue.3 , pp. 245-247
    • Blelloch, R.1    Venere, M.2    Yen, J.3    Ramalho-Santos, M.4
  • 60
    • 50849142559 scopus 로고    scopus 로고
    • A high-efficiency system for the generation and study of human induced pluripotent stem cells
    • Maherali N, Ahfeldt T, Rigamonti A, Utikal J, Cowan C, Hochedlinger K: A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell (2008) 3 (3):340-345.
    • (2008) Cell Stem Cell , vol.3 , Issue.3 , pp. 340-345
    • Maherali, N.1    Ahfeldt, T.2    Rigamonti, A.3    Utikal, J.4    Cowan, C.5    Hochedlinger, K.6
  • 61
    • 39149115929 scopus 로고    scopus 로고
    • Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse
    • Stadtfeld M, Maherali N, Breault DT, Hochedlinger K: Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell (2008) 2(3):230-240.
    • (2008) Cell Stem Cell , vol.2 , Issue.3 , pp. 230-240
    • Stadtfeld, M.1    Maherali, N.2    Breault, D.T.3    Hochedlinger, K.4
  • 62
    • 48249117043 scopus 로고    scopus 로고
    • Does retroviral insertional mutagenesis play a role in the generation of induced pluripotent stem cells?
    • Hawley RG: Does retroviral insertional mutagenesis play a role in the generation of induced pluripotent stem cells? Mol Ther (2008) 16(8):1354-1355.
    • (2008) Mol Ther , vol.16 , Issue.8 , pp. 1354-1355
    • Hawley, R.G.1
  • 66
    • 44049103962 scopus 로고    scopus 로고
    • Adeno-associated virus integration: Virus versus vector
    • Smith RH: Adeno-associated virus integration: virus versus vector. Gene Ther (2008) 15(11):817-22.
    • (2008) Gene Ther , vol.15 , Issue.11 , pp. 817-822
    • Smith, R.H.1
  • 67
    • 65649116572 scopus 로고    scopus 로고
    • Human induced pluripotent stem cells free of vector and transgene sequences
    • Yu J, Hu K, Smuga-Otto K, Tian S, Stewart R, Slukvin II, Thomson JA: Human induced pluripotent stem cells free of vector and transgene sequences. Science (2009) 324 (5928): 797-801.
    • (2009) Science , vol.324 , Issue.5928 , pp. 797-801
    • Yu, J.1    Hu, K.2    Smuga-Otto, K.3    Tian, S.4    Stewart, R.5    Slukvin, I.I.6    Thomson, J.A.7
  • 69
    • 33845981514 scopus 로고    scopus 로고
    • PiggyBac transposon-mediated gene transfer in human cells
    • Wilson MH, Coates CJ, George Al Jr: PiggyBac transposon-mediated gene transfer in human cells. Mol Ther (2007) 15(1):139-145.
    • (2007) Mol Ther , vol.15 , Issue.1 , pp. 139-145
    • Wilson, M.H.1    Coates, C.J.2    George Jr, A.3
  • 70
    • 65449154892 scopus 로고    scopus 로고
    • Generation of transgenefree induced pluripotent mouse stem cells by the piggyBac transposon
    • Yusa K, Rad R, Takeda J, Bradley A: Generation of transgenefree induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods (2009) 6(5):363-369.
    • (2009) Nat Methods , vol.6 , Issue.5 , pp. 363-369
    • Yusa, K.1    Rad, R.2    Takeda, J.3    Bradley, A.4
  • 71
    • 55849117368 scopus 로고    scopus 로고
    • Generation of mouse induced pluripotent stem cells without viral vectors
    • Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S: Generation of mouse induced pluripotent stem cells without viral vectors. Science (2008) 322 (5903):949-953.
    • (2008) Science , vol.322 , Issue.5903 , pp. 949-953
    • Okita, K.1    Nakagawa, M.2    Hyenjong, H.3    Ichisaka, T.4    Yamanaka, S.5
  • 72
    • 68649084609 scopus 로고    scopus 로고
    • Describes the generation of iPS cells using plasmid transfection, and demonstrates that alternatives to the use of viral vectors exist
    • Describes the generation of iPS cells using plasmid transfection, and demonstrates that alternatives to the use of viral vectors exist.
  • 73
    • 46949085597 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    • Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA: Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 26(7):795- 797.
    • (2008) Nat Biotechnol , vol.26 , Issue.7 , pp. 795-797
    • Huangfu, D.1    Maehr, R.2    Guo, W.3    Eijkelenboom, A.4    Snitow, M.5    Chen, A.E.6    Melton, D.A.7
  • 74
    • 68649104152 scopus 로고    scopus 로고
    • Demonstrated that small molecules can increase the efficiencies of pluripotent cell induction
    • Demonstrated that small molecules can increase the efficiencies of pluripotent cell induction.
  • 76
    • 68649117553 scopus 로고    scopus 로고
    • First study to demonstrate that iPS cells can be generated without introducing exogenous genetic sequences, bringing the use of iPS cells closer to clinical applications
    • First study to demonstrate that iPS cells can be generated without introducing exogenous genetic sequences, bringing the use of iPS cells closer to clinical applications.
  • 79
    • 44349103591 scopus 로고    scopus 로고
    • A combined chemical and genetic approach for the generation of induced pluripotent stem cells
    • Shi Y, Do JT, Desponts C, Hahm HS, Schöler HR, Ding S: A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 2(6): 525-528.
    • (2008) Cell Stem Cell , vol.2 , Issue.6 , pp. 525-528
    • Shi, Y.1    Do, J.T.2    Desponts, C.3    Hahm, H.S.4    Schöler, H.R.5    Ding, S.6
  • 82
    • 39149130361 scopus 로고    scopus 로고
    • Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
    • Jaenisch R, Young R: Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 132(4):567-582.
    • (2008) Cell , vol.132 , Issue.4 , pp. 567-582
    • Jaenisch, R.1    Young, R.2
  • 84
    • 66149179125 scopus 로고    scopus 로고
    • Deconstructing stem cell tumorigenicity: A roadmap to safe regenerative medicine
    • Knoepfer PS: Deconstructing stem cell tumorigenicity: A roadmap to safe regenerative medicine. Stem Cells (2009) 27(5):1050-1056.
    • (2009) Stem Cells , vol.27 , Issue.5 , pp. 1050-1056
    • Knoepfer, P.S.1
  • 86
    • 60649084367 scopus 로고    scopus 로고
    • Induced pluripotent stem cells: Current progress and potential for regenerative medicine
    • Amabile G, Meissner A: Induced pluripotent stem cells: Current progress and potential for regenerative medicine. Trends Mol Med (2009) 15(2):59-68.
    • (2009) Trends Mol Med , vol.15 , Issue.2 , pp. 59-68
    • Amabile, G.1    Meissner, A.2
  • 87
    • 48349106268 scopus 로고    scopus 로고
    • Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1
    • Choo AB, Tan HL, Ang SN, Fong WJ, Chin A, Lo J, Zheng L, Hentze H, Philp RJ, Oh SK, Yap M: Selection against undifferentiated human embryonic stem cells by a cytotoxic antibody recognizing podocalyxin-like protein-1. Stem Cells (2008) 26(6):1454-1463.
    • (2008) Stem Cells , vol.26 , Issue.6 , pp. 1454-1463
    • Choo, A.B.1    Tan, H.L.2    Ang, S.N.3    Fong, W.J.4    Chin, A.5    Lo, J.6    Zheng, L.7    Hentze, H.8    Philp, R.J.9    Oh, S.K.10    Yap, M.11
  • 88
    • 0038700553 scopus 로고    scopus 로고
    • Selective ablation of human embryonic stem cells expressing a 'suicide' gene
    • Schuldiner M, Itskovitz-Eldor J, Benvenisty N: Selective ablation of human embryonic stem cells expressing a 'suicide' gene. Stem Cells (2003) 21(3):257-265.
    • (2003) Stem Cells , vol.21 , Issue.3 , pp. 257-265
    • Schuldiner, M.1    Itskovitz-Eldor, J.2    Benvenisty, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.