Carbonic anhydrase inhibitors; Fluorinated phenyl sulfamates show strong inhibitory activity and selectivity for the inhibition of the tumor-associated isozymes IX and XII over the cytosolic ones I and II

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5082-5085

  Winum, Jean Yves ^a   Innocenti, Alessio ^b   Vullo, Daniela ^b   Montero, Jean Louis ^a   Supuran, Claudiu T ^b  

^a UNIV MONTPELLIER   (France)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic anhydrase; Fluorophenyl; Selective inhibitor; Sulfamate; Tumor associated isoforms

Indexed keywords

ACETAZOLAMIDE; BENZENE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; DORZOLAMIDE; SULFUR ACID DERIVATIVE;

ARTICLE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; PROTEIN EXPRESSION; REACTION ANALYSIS;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; HUMANS; PROTEIN ISOFORMS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS;

EID: 68349154361     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.056     Document Type: Article

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