Potent, selective human β3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 13, 1999, Pages 1869-1874

  Mathvink, Robert J ^a   Barritta, Anna Maria ^a   Candelore, Mari R ^a   Cascieri, Margaret A ^a   Deng, Liping ^a   Tota, Laurie ^a   Strader, Catherine D ^a   Wyvratt, Matthew J ^a   Fisher, Michael H ^a   Weber, Ann E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 OCTYLTHIAZOLE DERIVATIVE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; HETEROCYCLIC COMPOUND; INDOLINE 5 SULFONAMIDE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG; UREA; ADRENERGIC RECEPTOR STIMULATING AGENT; INDOLE DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL MODEL; HAMSTER; SYNTHESIS;

ADRENERGIC AGONISTS; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; INDOLES; MODELS, CHEMICAL; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0033526662     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00277-2     Document Type: Article

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