Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1- phosphate and FTY720: Discovery of potent S1P1 receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 15, 2005, Pages 3568-3572

  Clemens, Jeremy J ^a   Davis, Michael D ^a   Lynch, Kevin R ^a,b   Macdonald, Timothy L ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Bradycardia; FTY720; Phosphothioate; S1P receptor agonists; S1P1; Sphingosine 1 phosphate

Indexed keywords

4 PHENYLIMIDAZOLE; FINGOLIMOD; GUANOSINE TRIPHOSPHATE; IMIDAZOLE DERIVATIVE; RECEPTOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; UNCLASSIFIED DRUG;

AGONIST; ARTICLE; BINDING ASSAY; COMPARATIVE STUDY; DERIVATIZATION; DRUG ACTIVITY; DRUG POTENCY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IMMUNOMODULATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZIMIDAZOLES; BINDING SITES; BRADYCARDIA; CHO CELLS; CRICETINAE; IMMUNOSUPPRESSIVE AGENTS; LETHAL DOSE 50; LYSOPHOSPHOLIPIDS; PROPYLENE GLYCOLS; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21744439256     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.097     Document Type: Article

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