Engineering of glycerol-stimulated insulin secretion in islet beta cells. Differential metabolic fates of glucose and glycerol provide insight into mechanisms of stimulus-secretion coupling

Journal of Biological Chemistry

Volumn 272, Issue 30, 1997, Pages 18621-18627

  Noel, Richard J ^b   Antinozzi, Peter A ^b   McGarry, J Denis ^b   Newgard, Christopher B ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; FATTY ACID; GLUCOSE; GLYCERALDEHYDE; GLYCEROL; GLYCEROL KINASE; GLYCEROPHOSPHATE; INSULIN; LONG CHAIN FATTY ACID COENZYME A LIGASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ESTERIFICATION; FATTY ACID OXIDATION; GENETIC ENGINEERING; GLUCOSE METABOLISM; GLYCOLYSIS; INSULIN RELEASE; INSULINOMA; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STIMULUS SECRETION COUPLING;

ADENOVIRIDAE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUCOSE; GLYCEROL; GLYCEROL KINASE; INSULIN; ISLETS OF LANGERHANS; LACTIC ACID; RATS; RNA, MESSENGER; TRIAZENES; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0030753653     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.30.18621     Document Type: Article

References (33)

1. Meglasson M. D., and Matschinsky, F. M. (1986) Diabetes Metab. Rev. 2, 163-214
2. Newgard, C. B., and McGarry J. D. (1995) Annu. Rev. Biochem. 64, 689-719
3. Hedeskov, C. J. (1980) Physiol.l Rev. 60, 442-510
4. MacDonald, M. J., and Fahien, L. A. (1990) Arch. Biochem. Biophys. 279, 104-108
5. Mertz, R. J., Worley, J. F., III, Spencer, B., Johnson, J. H., and Dukes, I. D. (1996) J. Biol. Chem. 271, 4838-4845
6. Weis, J, N., and Lamp, S. T. (1987) Science 238, 67-69
7. Duchen, M. R., Smith, P. A., and Ashcroft, F. M. (1993) Biochem J. 294, 35-42
8. Corkey, B. E., Glennon, M. C., Chen, K. S., Deeney, J. T., Matschinsky, F. M., and Prentki, M. (1989) J. Biol. Chem. 264, 21608-21612
9. Prentki, M., Vischer, S., Glennon, M. C., Regazzi, R., Deeney, J. T., and Corkey, B. E. (1992) J. Biol. Chem. 267, 5802-5810
10. Chen, S., Ogawa, A., Ohneda, M., Unger, R. H., Foster, D. W., and McGarry, J. D. (1994) Diabetes 43, 878-883
11. MacDonald, M. J. (1981) J. Biol. Chem. 256, 8287-8290
12. MacDonald, M. J. (1990) Diabetes 39, 1461-1466
13. Dukes, I. D., McIntyre, M. S., Mertz, R. J., Philipson, L. H., Roe, M. W., Spencer, B., and Worley, J. F., III (1994) J. Biol. Chem. 269, 10979-10982
14. Yilmaz, M. T., Sener, A., and Malaisse, W. J. (1987) Mol. Cell. Endocrinol. 52, 251-256
15. Sener, A., Rasschaert, J., Zahner, D., and Malaisse, W. J. (1988) Int. J. Biochem. 20, 595-598
16. Becker, T. C., Noel, R. J., Coats, W. S., Gomez-Foix, A. M., Alam, T., and Newgard, C. B. (1994) Methods Cell Biol. 43, 162-189
17. Becker, T. C., BeltrandelRio, H., Noel, R. J., Johnson, J. H., and Newgard, C. B. (1994) J. Biol. Chem. 269, 21234-21238
18. Becker, T. C., Noel, R. J., Johnson, J. H., Lynch, R. M., Hirose, H., Tokuyama, Y., Bell, G. I., and Newgard, C. B. (1996) J. Biol. Chem. 271, 390-394
19. Pettigrew, D. W., Ma, D.-P., Conrad, C. A., and Johnson, J. R. (1988) J. Biol. Chem. 263, 135-139
20. Gomez-Foix, A. M., Coats, W. S., Baque, S., Alam, T., Gerard, R. D., and Newgard, C. B. (1992) J. Biol. Chem. 267, 25129-25134
21. McCrory, W. J., Bautista, D. S., and Graham, F. L. (1988) Virology 163, 614-617
22. Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P. A., and Wollheim, C. B. (1991) Endocrinology 130, 167-178
23. Herz, J., and Gerard, R. D. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2812-2816
24. Johnson, J. H., Newgard, C. B., Milburn, J. L., Lodish, H. F., and Thorens, B. (1990) J. Biol. Chem. 265, 6548-6551
25. Miyaura, C., Chen, L., Appel, M., Alam, T., Hughes, S. D., Milburn, J. L., Unger, R. H., and Newgard, C. B. (1991) Mol. Endocrinol. 5, 226-234
26. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
27. Kuwajima, M., Newgard, C. B., Foster, D. W., and McGarry, J. D. (1986) J. Biol. Chem. 261, 8849-8853
28. Milburn, J. L., Jr., Hirose, H., Lee, Y. H., Nagasawa, Y., Ogawa, A., Ohneda, M., BeltrandelRio, H., Newgard, C. B., Johnson, J. H., and Unger, R. H. (1995) J. Biol. Chem. 270, 1295-1299
29. Ferber, S., BeltrandelRio, H., Johnson, J. H., Noel, R. J., Cassidy, L. E., Clark, S., Becker, T. C., Hughes, S. D., and Newgard, C. B. (1994) J. Biol. Chem., 269, 11523-11529
30. Lin, E. (1976) Annu. Rev. Microbiol. 30, 535-578
31. MacDonald, M. J. (1982) Horm. Metab. Res. 14, 678-679
32. Tomoda, H., Igarashi, K., and Omura, S. (1987) Biochim. Biophys. Acta 921, 595-598
33. Stein, D. T., Esser, V., Stevenson, B. E., Lane, K. E., Whiteside, J. H., Daniels, M. B., Chen, S., and McGarry, J. D. (1996) J. Clin. Invest. 97, 2728-2735