PKCepsilon mediates glucose-regulated insulin production in pancreatic beta-cells

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1783, Issue 10, 2008, Pages 1929-1934

  Warwar, Nasim ^a   Dov, Avital ^a   Abramovitch, Eva ^a   Wu, Ren ^a   Jmoudiak, Marina ^a   Haber, Esther ^a   Cerasi, Erol ^a   Nesher, Rafael ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

COP1; Anchoring proteins; Proinsulin biosynthesis; siRNA; Translocation inhibiting peptides

Indexed keywords

BINDING PROTEIN; COATOMER PROTEIN; PROINSULIN; PROTEIN KINASE C EPSILON; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; GLUCONEOGENESIS; GLUCOSE METABOLISM; GOLGI COMPLEX; INSULIN RESPONSE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; TRANS GOLGI NETWORK;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MALE; PROTEIN KINASE C-EPSILON; PROTEIN TRANSPORT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

RATTUS;

EID: 50849130230     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2008.04.007     Document Type: Article

References (31)

1. Schuit F., Flamez D., De Vos A., and Pipeleers D. Glucose-regulated gene expression maintaining the glucose-responsive state of beta-cells. Diabetes 51 Suppl 3 (2002) S326-S332
2. Deeney J.T., Prentki M., and Corkey B.E. Metabolic control of beta-cell function. Semin. Cell Dev. Biol. 11 (2000) 267-275
3. Jones P.M., and Persaud S.J. Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic beta-cells. Endocr. Rev. 19 (1998) 429-461
4. Schechtman D., and Mochly-Rosen D. Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 20 (2001) 6339-6347
5. Warwar N., Efendic S., Ostenson C.G., Haber E.P., Cerasi E., and Nesher R. Dynamics of glucose-induced localization of PKC isoenzymes in pancreatic beta-cells: diabetes-related changes in the GK rat. Diabetes 55 (2006) 590-599
6. Yedovitzky M., Mochly-Rosen D., Johnson J.A., Gray M.O., Ron D., Abramovitch E., Cerasi E., and Nesher R. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells. J. Biol. Chem. 272 (1997) 1417-1420
7. Rao V.U., Shiraishi H., and McDermott P.J. PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth. Am. J. Physiol. 286 (2004) H2195-H2203
8. Wu D., Foreman T.L., Gregory C.W., McJilton M.A., Wescott G.G., Ford O.H., Alvey R.F., Mohler J.L., and Terrian D.M. Protein kinase Cepsilon has the potential to advance the recurrence of human prostate cancer. Cancer Res. 62 (2002) 2423-2429
9. Xu T.R., and Rumsby M.G. Phorbol ester-induced translocation of PKC epsilon to the nucleus in fibroblasts: identification of nuclear PKC epsilon-associating proteins. FEBS Lett. 570 (2004) 20-24
10. Akita Y. Protein kinase C-epsilon (PKC-epsilon): its unique structure and function. J. Biochem. 132 (2002) 847-852
11. Csukai M., Chen C.H., De Matteis M.A., and Mochly-Rosen D. The coatomer protein beta′-COP, a selective binding protein (RACK) for protein kinase Cepsilon. J. Biol. Chem. 272 (1997) 29200-29206
12. Schechtman D., Craske M.L., Kheifets V., Meyer T., Schechtman J., and Mochly-Rosen D. A critical intramolecular interaction for protein kinase Cepsilon translocation. J. Biol. Chem. 279 (2004) 15831-15840
13. Nesher R., Waldman L., and Cerasi E. Time-dependent inhibition of insulin release: glucose-arginine interactions in the perfused rat pancreas. Diabetologia 26 (1984) 146-149
14. Gadot M., Leibowitz G., Shafrir E., Cerasi E., Gross D.J., and Kaiser N. Hyperproinsulinemia and insulin deficiency in the diabetic Psammomys obesus. Endocrinology 135 (1994) 610-616
15. Nesher R., Warwar N., Khan A., Efendic S., Cerasi E., and Kaiser N. Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes. Diabetes 50 (2001) 308-314
16. Elbashir S.M., Harborth J., Weber K., and Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26 (2002) 199-213
17. Shinohara H., Kayagaki N., Yagita H., Oyaizu N., Ohba M., Kuroki T., and Ikawa Y. A protective role of PKCe against TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in glioma cells. Biochem. Biophys. Res. Commun. 284 (2001) 1162-1167
18. He T., Zhou S., da Costa L., Yu J., Kinzler K., and Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 2509-2514
19. Halban P.A., Rhodes C.J., and Shoelson S.E. High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin. Diabetologia 29 (1986) 893-896
20. Zambre Y., Ling Z., Hou X., Foriers A., Van Den Bogaert B., Van Schravendijk C., and Pipeleers D. Effect of glucose on production and release of proinsulin conversion products by cultured human islets. J. Clin. Endocrinol. Metab. 83 (1998) 1234-1238
21. Mendez C.F., Leibiger I.B., Leibiger B., Hoy M., Gromada J., Berggren P.O., and Bertorello A.M. Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis. J. Biol. Chem. 278 (2003) 44753-44757
22. Gold G., Gishizky M.L., and Grodsky G.M. Evidence that glucose "marks" beta cells resulting in preferential release of newly synthesized insulin. Science 218 (1982) 56-58 (New York, N.Y
23. Halban P.A. Differential rates of release of newly synthesized and of stored insulin from pancreatic islets. Endocrinology 110 (1982) 1183-1188
24. Sando H., Borg J., and Steiner D.F. Studies on the secretion of newly synthesized proinsulin and insulin from isolated rat islets of Langerhans. J. Clin. Invest. 51 (1972) 1476-1485
25. Van Schravendijk C.F., Kiekens R., and Pipeleers D.G. Pancreatic beta cell heterogeneity in glucose-induced insulin secretion. J. Biol. Chem. 267 (1992) 21344-21348
26. Gadot M., Ariav Y., Cerasi E., Kaiser N., and Gross D.J. Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the beta-cell. Endocrinology 136 (1995) 4218-4223
27. Gomez E., Powell M.L., Greenman I.C., and Herbert T.P. Glucose-stimulated protein synthesis in pancreatic beta-cells parallels an increase in the availability of the translational ternary complex (eIF2-GTP.Met-tRNAi) and the dephosphorylation of eIF2 alpha. J. Biol. Chem. 279 (2004) 53937-53946
28. Mochly-Rosen D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science 268 (1995) 247-251
29. Mochly-Rosen D., and Gordon A.S. Anchoring proteins for protein kinase C: a means for isozyme selectivity. Faseb J. 12 (1998) 35-42
30. Shirai Y., Kashiwagi K., Yagi K., Sakai N., and Saito N. Distinct effects of fatty acids on translocation of gamma- and epsilon-subspecies of protein kinase C. J. Cell Biol. 143 (1998) 511-521
31. Schmitz-Peiffer C., Laybutt D.R., Burchfield J.G., Gurisik E., Narasimhan S., Mitchell C.J., Pedersen D.J., Braun U., Cooney G.J., Leitges M., and Biden T.J. Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab 6 (2007) 320-328