Reduced or diminished stabilization of the telomere G-quadruplex and inhibition of telomerase by small chemical ligands under molecular crowding condition

Journal of the American Chemical Society

Volumn 131, Issue 30, 2009, Pages 10430-10438

  Chen, Zhao ^a   Zheng, Ke Wei ^a   Hao, Yu Hua ^b   Tan, Zheng ^a,b  

^a WUHAN UNIVERSITY   (China)

^b INSTITUTE OF ZOOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICANCER EFFECTS; BINDING AFFINITIES; CANCER CELLS; CELL DIVISIONS; DILUTE SOLUTION; DNA REPLICATIONS; G-QUADRUPLEX; G-QUADRUPLEX STRUCTURE; HUMAN CELLS; IN-VITRO; IN-VIVO; MOLECULAR CROWDING; TELOMERASE; TELOMERE; TELOMERE DNA; WATER ACTIVITY;

BINDING ENERGY; CELL MEMBRANES; CELL PROLIFERATION; DNA; GENES; NUCLEIC ACIDS; STABILIZATION;

LIGANDS;

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; GLYCEROL; GUANINE QUADRUPLEX; K RAS PROTEIN; LIGAND; MACROGOL 200; OLIGONUCLEOTIDE; PORPHYRIN DERIVATIVE; QUANINE QUADRUPLEX LIGAND; TELOMERASE; UNCLASSIFIED DRUG; WATER;

ARTICLE; BINDING AFFINITY; DILUTION; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGAND BINDING; MOLECULAR STABILITY; MOLECULE; TELOMERE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; VISCOSITY;

BASE SEQUENCE; G-QUADRUPLEXES; GLYCEROL; HUMANS; LIGANDS; POLYETHYLENE GLYCOLS; REVERSE TRANSCRIPTASE INHIBITORS; TELOMERASE; TELOMERE; VISCOSITY; WATER;

EID: 68049109541     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9010749     Document Type: Article

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