-
1
-
-
0036562180
-
Focus on breast cancer
-
Baselga J, Norton L. Focus on breast cancer. Cancer Cell 2002;1:319-22.
-
(2002)
Cancer Cell
, vol.1
, pp. 319-322
-
-
Baselga, J.1
Norton, L.2
-
2
-
-
0024337144
-
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
-
Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-12.
-
(1989)
Science
, vol.244
, pp. 707-712
-
-
Slamon, D.J.1
Godolphin, W.2
Jones, L.A.3
-
3
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-82.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
4
-
-
0025190758
-
Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung
-
Weiner DB, Nordberg J, Robinson R, et al. Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lung. Cancer Res 1990;50:421-5.
-
(1990)
Cancer Res
, vol.50
, pp. 421-425
-
-
Weiner, D.B.1
Nordberg, J.2
Robinson, R.3
-
5
-
-
0027215064
-
Heterogeneity of erb B-2 gene amplification in bladder cancer
-
Sauter G, Moch H, Moore D, et al. Heterogeneity of erb B-2 gene amplification in bladder cancer. Cancer Res 1993;53:2199-203.
-
(1993)
Cancer Res
, vol.53
, pp. 2199-2203
-
-
Sauter, G.1
Moch, H.2
Moore, D.3
-
6
-
-
0034929997
-
The HER-2/neu oncogene in tumors of the gastrointestinal tract
-
Ross JS, McKenna BJ. The HER-2/neu oncogene in tumors of the gastrointestinal tract. Cancer Invest 2001;19:554-68.
-
(2001)
Cancer Invest
, vol.19
, pp. 554-568
-
-
Ross, J.S.1
McKenna, B.J.2
-
7
-
-
0023713558
-
Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
-
Muller WJ, Sinn E, Pattengale PK, Wallace R, Leder P. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 1988;54:105-15.
-
(1988)
Cell
, vol.54
, pp. 105-115
-
-
Muller, W.J.1
Sinn, E.2
Pattengale, P.K.3
Wallace, R.4
Leder, P.5
-
8
-
-
0024405949
-
Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene
-
Bouchard L, Lamarre L, Tremblay PJ, Jolicoeur P. Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene. Cell 1989;57:931-6.
-
(1989)
Cell
, vol.57
, pp. 931-936
-
-
Bouchard, L.1
Lamarre, L.2
Tremblay, P.J.3
Jolicoeur, P.4
-
9
-
-
0034738969
-
Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development
-
Kiguchi K, Bol D, Carbajal S, et al. Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development. Oncogene 2000;19:4243-54.
-
(2000)
Oncogene
, vol.19
, pp. 4243-4254
-
-
Kiguchi, K.1
Bol, D.2
Carbajal, S.3
-
10
-
-
19044370434
-
Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis
-
Moody SE, Sarkisian CJ, Hahn KT, et al. Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis. Cancer Cell 2002;2:451-61.
-
(2002)
Cancer Cell
, vol.2
, pp. 451-461
-
-
Moody, S.E.1
Sarkisian, C.J.2
Hahn, K.T.3
-
11
-
-
0033996361
-
ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: Receptor overexpression does not determine growth dependency
-
Lane HA, Beuvink I, Motoyama AB, Daly JM, Neve RM, Hynes NE. ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency. Mol Cell Biol 2000;20:3210-23.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3210-3223
-
-
Lane, H.A.1
Beuvink, I.2
Motoyama, A.B.3
Daly, J.M.4
Neve, R.M.5
Hynes, N.E.6
-
13
-
-
0037179871
-
Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells
-
Timms JF, White SL, O'Hare MJ, Waterfield MD. Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells. Oncogene 2002;21:6573-86.
-
(2002)
Oncogene
, vol.21
, pp. 6573-6586
-
-
Timms, J.F.1
White, S.L.2
O'Hare, M.J.3
Waterfield, M.D.4
-
14
-
-
10744230388
-
Switching off HER-2/neu in a tetracycline-controlled mouse tumor model leads to apoptosis and tumor-size-dependent remission
-
Schiffer IB, Gebhard S, Heimerdinger CK, et al. Switching off HER-2/neu in a tetracycline-controlled mouse tumor model leads to apoptosis and tumor-size-dependent remission. Cancer Res 2003;63:7221-31.
-
(2003)
Cancer Res
, vol.63
, pp. 7221-7231
-
-
Schiffer, I.B.1
Gebhard, S.2
Heimerdinger, C.K.3
-
15
-
-
0030900653
-
The cat and mouse games that genes, viruses, and cells play
-
Weinberg HA. The cat and mouse games that genes, viruses, and cells play. Cell 1997;88:573-5.
-
(1997)
Cell
, vol.88
, pp. 573-575
-
-
Weinberg, H.A.1
-
16
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol 2001;11:S27-31.
-
(2001)
Trends Cell Biol
, vol.11
-
-
Campisi, J.1
-
17
-
-
0038277105
-
Tumor cell senescence in cancer treatment
-
Roninson IB. Tumor cell senescence in cancer treatment. Cancer Res 2003;63:2705-15.
-
(2003)
Cancer Res
, vol.63
, pp. 2705-2715
-
-
Roninson, I.B.1
-
18
-
-
3543092021
-
Pathways of apoptotic and non-apoptotic death in tumour cells
-
Okada H, Mak TW. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer 2004;4:592-603.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 592-603
-
-
Okada, H.1
Mak, T.W.2
-
19
-
-
0036561908
-
Modelling the molecular circuitry of cancer
-
Hahn WC, Weinberg RA. Modelling the molecular circuitry of cancer. Nat Rev Cancer 2002;2:331-41.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 331-341
-
-
Hahn, W.C.1
Weinberg, R.A.2
-
20
-
-
0037148276
-
Senescence: Does it all happen at the ends?
-
Stewart SA, Weinberg RA. Senescence: does it all happen at the ends? Oncogene 2002;21:627-30.
-
(2002)
Oncogene
, vol.21
, pp. 627-630
-
-
Stewart, S.A.1
Weinberg, R.A.2
-
21
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
22
-
-
0346463059
-
High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts
-
Deng Q, Liao R, Wu BL, Sun P. High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J Biol Chem 2004;279:1050-9.
-
(2004)
J Biol Chem
, vol.279
, pp. 1050-1059
-
-
Deng, Q.1
Liao, R.2
Wu, B.L.3
Sun, P.4
-
23
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 1998;12:3008-19.
-
(1998)
Genes Dev
, vol.12
, pp. 3008-3019
-
-
Lin, A.W.1
Barradas, M.2
Stone, J.C.3
Van Aelst, L.4
Serrano, M.5
Lowe, S.W.6
-
24
-
-
0030835430
-
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
-
Woods D, Parry D, Cherwinski H, Bosch E, Lees E, McMahon M. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol 1997;17:5598-611.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5598-5611
-
-
Woods, D.1
Parry, D.2
Cherwinski, H.3
Bosch, E.4
Lees, E.5
McMahon, M.6
-
25
-
-
0030871667
-
High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
-
Sewing A, Wiseman B, Lloyd AC, Land H. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol Cell Biol 1997;17:5588-97.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5588-5597
-
-
Sewing, A.1
Wiseman, B.2
Lloyd, A.C.3
Land, H.4
-
26
-
-
0032192153
-
Senescence of human fibroblasts induced by oncogenic Raf
-
Zhu J, Woods D, McMahon M, Bishop JM. Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev 1998;12:2997-3007.
-
(1998)
Genes Dev
, vol.12
, pp. 2997-3007
-
-
Zhu, J.1
Woods, D.2
McMahon, M.3
Bishop, J.M.4
-
27
-
-
0036242247
-
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
-
Wang W, Chen JX, Liao R, et al. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol 2002;22:3389-403.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3389-3403
-
-
Wang, W.1
Chen, J.X.2
Liao, R.3
-
28
-
-
0029022369
-
Transcriptional activation by tetracyclines in mammalian cells
-
Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science 1995;268:1766-9.
-
(1995)
Science
, vol.268
, pp. 1766-1769
-
-
Gossen, M.1
Freundlieb, S.2
Bender, G.3
Muller, G.4
Hillen, W.5
Bujard, H.6
-
29
-
-
0033961809
-
Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
-
Lee RJ, Albanese C, Fu M, et al. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol Cell Biol 2000;20:672-83.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 672-683
-
-
Lee, R.J.1
Albanese, C.2
Fu, M.3
-
30
-
-
0022485548
-
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185
-
Bargmann CI, Hung MC, Weinberg RA. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell 1986;45:649-57.
-
(1986)
Cell
, vol.45
, pp. 649-657
-
-
Bargmann, C.I.1
Hung, M.C.2
Weinberg, R.A.3
-
31
-
-
0032544686
-
Tumor induction of VEGF promoter activity in stromal cells
-
Fukumura D, Xavier R, Sugiura T, et al. Tumor induction of VEGF promoter activity in stromal cells. Cell 1998;94:715-25.
-
(1998)
Cell
, vol.94
, pp. 715-725
-
-
Fukumura, D.1
Xavier, R.2
Sugiura, T.3
-
32
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995;92:9363-7.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
-
33
-
-
0032033156
-
Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development
-
Spangenberg C, Winterpacht A, Zabel BU, Lobbert RW. Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. Genomics 1998;48:178-85.
-
(1998)
Genomics
, vol.48
, pp. 178-185
-
-
Spangenberg, C.1
Winterpacht, A.2
Zabel, B.U.3
Lobbert, R.W.4
-
34
-
-
0036606633
-
Mechanisms of growth arrest by c-myc antisense oligonucleotides in MCF-7 breast cancer cells: Implications for the antiproliferative effects of antiestrogens
-
Carroll JS, Swarbrick A, Musgrove EA, Sutherland RL. Mechanisms of growth arrest by c-myc antisense oligonucleotides in MCF-7 breast cancer cells: implications for the antiproliferative effects of antiestrogens. Cancer Res 2002;62:3126-31.
-
(2002)
Cancer Res
, vol.62
, pp. 3126-3131
-
-
Carroll, J.S.1
Swarbrick, A.2
Musgrove, E.A.3
Sutherland, R.L.4
-
36
-
-
0025352187
-
Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
-
Morgenstern JP, Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 1990;18:3587-96.
-
(1990)
Nucleic Acids Res
, vol.18
, pp. 3587-3596
-
-
Morgenstern, J.P.1
Land, H.2
-
37
-
-
0034608802
-
Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
-
Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard H, Hillen W. Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci U S A 2000;97:7963-8.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 7963-7968
-
-
Urlinger, S.1
Baron, U.2
Thellmann, M.3
Hasan, M.T.4
Bujard, H.5
Hillen, W.6
-
38
-
-
0034745353
-
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
-
Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 2001;3:245-52.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 245-252
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Spohn, B.4
Lee, M.H.5
Hung, M.C.6
-
39
-
-
0032510327
-
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
-
McConnell BB, Starborg M, Brookes S, Peters G. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol 1998;8:351-4.
-
(1998)
Curr Biol
, vol.8
, pp. 351-354
-
-
McConnell, B.B.1
Starborg, M.2
Brookes, S.3
Peters, G.4
-
40
-
-
0037086268
-
DNA damage is able to induce senescence in tumor cells in vitro and in vivo
-
te Poele RH, Okorokov AL, Jardine L, Cummings J, Joel SP. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res 2002;62:1876-83.
-
(2002)
Cancer Res
, vol.62
, pp. 1876-1883
-
-
Te Poele, R.H.1
Okorokov, A.L.2
Jardine, L.3
Cummings, J.4
Joel, S.P.5
-
42
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
El Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993;75:817-25.
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
El Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
-
43
-
-
0031577480
-
Sodium butyrate induces N1H3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1 in p53-independent manner
-
Xiao H, Hasegawa T, Miyaishi O, Ohkusu K, Isobe K. Sodium butyrate induces N1H3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1 in p53-independent manner. Biochem Biophys Res Commun 1997;237:457-60.
-
(1997)
Biochem Biophys Res Commun
, vol.237
, pp. 457-460
-
-
Xiao, H.1
Hasegawa, T.2
Miyaishi, O.3
Ohkusu, K.4
Isobe, K.5
-
44
-
-
0034815687
-
p53-independent elevation of p21 expression by PMA results from PKC-mediated mRNA stabilization
-
Park JW, Jang MA, Lee YH, Passaniti A, Kwon TK. p53-independent elevation of p21 expression by PMA results from PKC-mediated mRNA stabilization. Biochem Biophys Res Commun 2001;280:244-8.
-
(2001)
Biochem Biophys Res Commun
, vol.280
, pp. 244-248
-
-
Park, J.W.1
Jang, M.A.2
Lee, Y.H.3
Passaniti, A.4
Kwon, T.K.5
-
45
-
-
0345932931
-
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway
-
Iwasa H, Han J, Ishikawa F. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 2003;8:131-44.
-
(2003)
Genes Cells
, vol.8
, pp. 131-144
-
-
Iwasa, H.1
Han, J.2
Ishikawa, F.3
-
46
-
-
0034213138
-
p38 MAP kinases: Beyond the stress response
-
Nebreda AR, Porras A. p38 MAP kinases: beyond the stress response. Trends Biochem Sci 2000;25:257-60.
-
(2000)
Trends Biochem Sci
, vol.25
, pp. 257-260
-
-
Nebreda, A.R.1
Porras, A.2
-
47
-
-
0032214980
-
Overexpression of ErbB2 blocks taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase
-
Yu D, Jing T, Liu B, et al. Overexpression of ErbB2 blocks taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Mol Cell 1998;2:581-91.
-
(1998)
Mol Cell
, vol.2
, pp. 581-591
-
-
Yu, D.1
Jing, T.2
Liu, B.3
-
48
-
-
0346485798
-
Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis
-
Winters ZE, Leek RD, Bradburn MJ, Norbury CJ, Harris AL. Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis. Breast Cancer Res 2003;5:R242-9.
-
(2003)
Breast Cancer Res
, vol.5
-
-
Winters, Z.E.1
Leek, R.D.2
Bradburn, M.J.3
Norbury, C.J.4
Harris, A.L.5
-
49
-
-
0037118575
-
AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival
-
Bacus SS, Altomare DA, Lyass L, et al. AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene 2002;21:3532-40.
-
(2002)
Oncogene
, vol.21
, pp. 3532-3540
-
-
Bacus, S.S.1
Altomare, D.A.2
Lyass, L.3
-
50
-
-
0032557492
-
Antibodies stage a comeback in cancer treatment
-
Dickman S. Antibodies stage a comeback in cancer treatment. Science 1998;280:1196-7.
-
(1998)
Science
, vol.280
, pp. 1196-1197
-
-
Dickman, S.1
-
51
-
-
0347628818
-
p21Waf1/Cip1 as a therapeutic target in breast and other cancers
-
Weiss RH. p21Waf1/Cip1 as a therapeutic target in breast and other cancers. Cancer Cell 2003;4:425-9.
-
(2003)
Cancer Cell
, vol.4
, pp. 425-429
-
-
Weiss, R.H.1
|