메뉴 건너뛰기




Volumn 33, Issue 8, 2009, Pages 904-910

DNA hypomethylation as Achilles' heel of tumorigenesis: A working hypothesis

Author keywords

5 Azacytidine; DNA hypomethylation; Latent polytene heterochromatinization; Pericentromeric heterochromatin; Somatic cancer cell biology

Indexed keywords

AZACITIDINE; GENOMIC DNA;

EID: 68049102037     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2009.02.018     Document Type: Article
Times cited : (8)

References (74)
  • 1
    • 23444454047 scopus 로고    scopus 로고
    • The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications
    • Ballestar E., and Esteller M. The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications. Prog Mol Subcell Biol 38 (2005) 169-181
    • (2005) Prog Mol Subcell Biol , vol.38 , pp. 169-181
    • Ballestar, E.1    Esteller, M.2
  • 2
    • 0036561649 scopus 로고    scopus 로고
    • Altered methylation pattern in cancer cell genomes: cause or consequence?
    • Baylin S., and Bestor T. Altered methylation pattern in cancer cell genomes: cause or consequence?. Cancer Cell 1 (2002) 299-305
    • (2002) Cancer Cell , vol.1 , pp. 299-305
    • Baylin, S.1    Bestor, T.2
  • 3
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: epigenetics joins genetics
    • Baylin S., and Herman J. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16 (2000) 168-174
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.1    Herman, J.2
  • 4
    • 0030846212 scopus 로고    scopus 로고
    • Alterations in DNA methylation - a fundamental aspect of neoplasia
    • Baylin S., Herman J., Graff J., Vertino P., and Issa J.-P. Alterations in DNA methylation - a fundamental aspect of neoplasia. Adv Cancer Res 72 (1998) 141-196
    • (1998) Adv Cancer Res , vol.72 , pp. 141-196
    • Baylin, S.1    Herman, J.2    Graff, J.3    Vertino, P.4    Issa, J.-P.5
  • 5
    • 34250633637 scopus 로고    scopus 로고
    • Cancer as a manifestation of aberrant chromatin structure
    • Brock M., Herman J., and Baylin S. Cancer as a manifestation of aberrant chromatin structure. Cancer J 13 (2007) 3-8
    • (2007) Cancer J , vol.13 , pp. 3-8
    • Brock, M.1    Herman, J.2    Baylin, S.3
  • 7
    • 33847293264 scopus 로고    scopus 로고
    • Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells
    • Chen T., Hevi S., Gay F., Tsujimoto N., He T., Zhang B., et al. Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet 39 (2007) 391-396
    • (2007) Nat Genet , vol.39 , pp. 391-396
    • Chen, T.1    Hevi, S.2    Gay, F.3    Tsujimoto, N.4    He, T.5    Zhang, B.6
  • 8
    • 0037068393 scopus 로고    scopus 로고
    • DNA methylation and gene silencing in cancer: which is the guilty party?
    • Clark S., and Melki J. DNA methylation and gene silencing in cancer: which is the guilty party?. Oncogene 21 (2002) 5380-5387
    • (2002) Oncogene , vol.21 , pp. 5380-5387
    • Clark, S.1    Melki, J.2
  • 9
    • 0028839835 scopus 로고
    • Alterations in DNA methylation may play a variety of roles in carcinogenesis
    • Counts J., and Goodman J. Alterations in DNA methylation may play a variety of roles in carcinogenesis. Cell 83 (1995) 13-15
    • (1995) Cell , vol.83 , pp. 13-15
    • Counts, J.1    Goodman, J.2
  • 10
    • 0032894211 scopus 로고    scopus 로고
    • Global DNA hypomethylation in breast carcinoma (correlation with prognostic factors and tumor progression)
    • Cravo M. Global DNA hypomethylation in breast carcinoma (correlation with prognostic factors and tumor progression). Cancer 85 (1999) 112-118
    • (1999) Cancer , vol.85 , pp. 112-118
    • Cravo, M.1
  • 11
    • 33750688857 scopus 로고    scopus 로고
    • Epigenetic tete-a-tete: the bilateral relationship between chromatin modifications and DNA methylation
    • D'Alessio A., and Szyf M. Epigenetic tete-a-tete: the bilateral relationship between chromatin modifications and DNA methylation. Biochem Cell Biol 84 (2002) 463-476
    • (2002) Biochem Cell Biol , vol.84 , pp. 463-476
    • D'Alessio, A.1    Szyf, M.2
  • 12
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal Instability and tumors promoted by DNA hypomethylation
    • Eden A., Gaudet E., Waghmare A., and Jaenisch R. Chromosomal Instability and tumors promoted by DNA hypomethylation. Science 300 (2003) 455
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, E.2    Waghmare, A.3    Jaenisch, R.4
  • 13
    • 0036324032 scopus 로고    scopus 로고
    • DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome, and chromosomal rearrangements
    • Ehrlich M. DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome, and chromosomal rearrangements. J Nutr 132 (2002) 2424S-2429S
    • (2002) J Nutr , vol.132
    • Ehrlich, M.1
  • 14
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: too much, but also too little
    • Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 21 (2002) 5400-5413
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1
  • 16
    • 0036145156 scopus 로고    scopus 로고
    • Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
    • Esteller M., and Herman J. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol 196 (2002) 1-7
    • (2002) J Pathol , vol.196 , pp. 1-7
    • Esteller, M.1    Herman, J.2
  • 17
    • 5444255150 scopus 로고    scopus 로고
    • The epigenetics of cancer etiology
    • Feinberg A. The epigenetics of cancer etiology. Semin Cancer Biol 14 (2004) 427-432
    • (2004) Semin Cancer Biol , vol.14 , pp. 427-432
    • Feinberg, A.1
  • 18
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg A., and Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301 (1983) 89-92
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.1    Vogelstein, B.2
  • 19
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • Feinberg A., Ohlsson R., and Henikoff S. The epigenetic progenitor origin of human cancer. Nat Rev Genet 7 (2006) 21-33
    • (2006) Nat Rev Genet , vol.7 , pp. 21-33
    • Feinberg, A.1    Ohlsson, R.2    Henikoff, S.3
  • 20
    • 4143140030 scopus 로고    scopus 로고
    • A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors
    • Fraga M., Herranz M., Espada J., Ballestar E., Paz M., Ropero S., et al. A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res 64 (2004) 5527-5534
    • (2004) Cancer Res , vol.64 , pp. 5527-5534
    • Fraga, M.1    Herranz, M.2    Espada, J.3    Ballestar, E.4    Paz, M.5    Ropero, S.6
  • 21
    • 3342971009 scopus 로고    scopus 로고
    • Quantitative evaluation of DNA in the nuclei of buccal epithelium in fibroadenoma, fibroadenomatosis and breast cancer
    • (Russian)
    • Ganina K., Borodai N., Petunin I., and Klinshin D. Quantitative evaluation of DNA in the nuclei of buccal epithelium in fibroadenoma, fibroadenomatosis and breast cancer. Exp Oncol (Ukraine) 20 (1998) 130-134 (Russian)
    • (1998) Exp Oncol (Ukraine) , vol.20 , pp. 130-134
    • Ganina, K.1    Borodai, N.2    Petunin, I.3    Klinshin, D.4
  • 22
    • 0036705608 scopus 로고    scopus 로고
    • DNA hypermethylation: when tumour suppressor genes go silent
    • Garinis G., Patrinos G., Spanakis N., and Menounos P. DNA hypermethylation: when tumour suppressor genes go silent. Hum Genet 111 (2002) 115-127
    • (2002) Hum Genet , vol.111 , pp. 115-127
    • Garinis, G.1    Patrinos, G.2    Spanakis, N.3    Menounos, P.4
  • 25
    • 0025049211 scopus 로고
    • Induction of invasive and metastatic potential in mouse T-lymphoma cells (BW5147) by treatment with 5-azacytidine
    • Habets G., van der Kammen R., Scholtes E., and Collard J. Induction of invasive and metastatic potential in mouse T-lymphoma cells (BW5147) by treatment with 5-azacytidine. Clin Exp Metastasis 8 (1990) 567-577
    • (1990) Clin Exp Metastasis , vol.8 , pp. 567-577
    • Habets, G.1    van der Kammen, R.2    Scholtes, E.3    Collard, J.4
  • 26
    • 33749117574 scopus 로고    scopus 로고
    • Recursive causality in evolution: a model for epigenetic mechanisms in cancer development
    • Haslberger A., Varga F., and Karlic H. Recursive causality in evolution: a model for epigenetic mechanisms in cancer development. Med Hypotheses 67 (2006) 1448-1454
    • (2006) Med Hypotheses , vol.67 , pp. 1448-1454
    • Haslberger, A.1    Varga, F.2    Karlic, H.3
  • 27
    • 33746461765 scopus 로고    scopus 로고
    • Epigenetic changes in cancer and preneoplasia
    • Herman J. Epigenetic changes in cancer and preneoplasia. Cold Spring Harb Symp Quant Biol 70 (2005) 329-333
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 329-333
    • Herman, J.1
  • 28
    • 0034095131 scopus 로고    scopus 로고
    • Promoter-region hypermethylation and gene silencing in human cancer
    • Herman J., and Baylin S. Promoter-region hypermethylation and gene silencing in human cancer. Curr Top Microbiol Immunol 249 (2000) 35-54
    • (2000) Curr Top Microbiol Immunol , vol.249 , pp. 35-54
    • Herman, J.1    Baylin, S.2
  • 29
    • 33746848188 scopus 로고    scopus 로고
    • New therapeutic targets in cancer: the epigenetic connection
    • Herranz M., and Esteller M. New therapeutic targets in cancer: the epigenetic connection. Clin Transl Oncol 8 (2006) 242-249
    • (2006) Clin Transl Oncol , vol.8 , pp. 242-249
    • Herranz, M.1    Esteller, M.2
  • 30
    • 24744471011 scopus 로고    scopus 로고
    • Causes and consequences of DNA hypomethylation in human cancer
    • Hoffmann M., and Schulz W. Causes and consequences of DNA hypomethylation in human cancer. Biochem Cell Biol 83 (2005) 246-321
    • (2005) Biochem Cell Biol , vol.83 , pp. 246-321
    • Hoffmann, M.1    Schulz, W.2
  • 31
    • 0032890965 scopus 로고    scopus 로고
    • The DNA methylation paradox
    • Jones P. The DNA methylation paradox. Trend Genet 15 (1998) 34-37
    • (1998) Trend Genet , vol.15 , pp. 34-37
    • Jones, P.1
  • 32
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones P., and Baylin S. The fundamental role of epigenetic events in cancer. Nat Rev Genet 3 (2002) 415-428
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.1    Baylin, S.2
  • 33
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones P., and Baylin S. The epigenomics of cancer. Cell 128 (2007) 683-692
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.1    Baylin, S.2
  • 34
    • 25444475765 scopus 로고    scopus 로고
    • Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells
    • Karpf A., and Matsui S.-I. Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer Res 65 (2005) 8635-8639
    • (2005) Cancer Res , vol.65 , pp. 8635-8639
    • Karpf, A.1    Matsui, S.-I.2
  • 35
    • 23944498278 scopus 로고    scopus 로고
    • DNA demethylation and carcinogenesis
    • Kisseljova N., and Kisseljov F. DNA demethylation and carcinogenesis. Biochemistry (Mosc) 70 (2005) 743-752
    • (2005) Biochemistry (Mosc) , vol.70 , pp. 743-752
    • Kisseljova, N.1    Kisseljov, F.2
  • 36
    • 68049092090 scopus 로고
    • Klaus G. (Ed), IRL Press, Oxford
    • In: Klaus G. (Ed). Lymphocytes, a practical approach (1987), IRL Press, Oxford 195
    • (1987) Lymphocytes, a practical approach , pp. 195
  • 38
    • 17444417521 scopus 로고    scopus 로고
    • Cancer epigenetics
    • Laird P. Cancer epigenetics. Hum Mol Genet 14 (2005) R65-R76
    • (2005) Hum Mol Genet , vol.14
    • Laird, P.1
  • 39
    • 0025806910 scopus 로고
    • DNA methylation and chromatin structure
    • Lewis J., and Bird A. DNA methylation and chromatin structure. FEBS Lett 5 (1991) 155-159
    • (1991) FEBS Lett , vol.5 , pp. 155-159
    • Lewis, J.1    Bird, A.2
  • 40
    • 0035872493 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in hepatocellular carcinogenesis
    • Lin C., Hsieh S., Sheen I., Lee W., Chen T., Shyn W., et al. Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Res 61 (2001) 239-245
    • (2001) Cancer Res , vol.61 , pp. 239-245
    • Lin, C.1    Hsieh, S.2    Sheen, I.3    Lee, W.4    Chen, T.5    Shyn, W.6
  • 41
    • 25844465921 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer with 5-aza-2′-deoxycytidine (decitabine)
    • Momparler R. Epigenetic therapy of cancer with 5-aza-2′-deoxycytidine (decitabine). Semin Oncol 32 (2005) 443-451
    • (2005) Semin Oncol , vol.32 , pp. 443-451
    • Momparler, R.1
  • 42
    • 27744566944 scopus 로고    scopus 로고
    • Lsh, a guardian of heterochromatin at repeat elements
    • Muegge K. Lsh, a guardian of heterochromatin at repeat elements. Biochem. Cell Biol 83 (2005) 548-554
    • (2005) Biochem. Cell Biol , vol.83 , pp. 548-554
    • Muegge, K.1
  • 43
    • 2442699984 scopus 로고    scopus 로고
    • DNA methylation pattern similar to normal tissue is associated with better prognosis in human cervical cancer
    • Muller H., Widschwendter A., Fiegl H., Goebel G., and Wiedemair A. DNA methylation pattern similar to normal tissue is associated with better prognosis in human cervical cancer. Cancer Lett 299 (2004) 231-236
    • (2004) Cancer Lett , vol.299 , pp. 231-236
    • Muller, H.1    Widschwendter, A.2    Fiegl, H.3    Goebel, G.4    Wiedemair, A.5
  • 44
    • 0030018599 scopus 로고    scopus 로고
    • Analysis of the DNA content distribution of micronuclei using flow sorting and fluorescent in situ hybridization with a centromeric DNA probe
    • Nusse M., Miller B., Viaggi S., and Grawe J. Analysis of the DNA content distribution of micronuclei using flow sorting and fluorescent in situ hybridization with a centromeric DNA probe. Mutagenesis 11 (1996) 405-413
    • (1996) Mutagenesis , vol.11 , pp. 405-413
    • Nusse, M.1    Miller, B.2    Viaggi, S.3    Grawe, J.4
  • 45
    • 0037373891 scopus 로고    scopus 로고
    • A systematic profile of DNA methylation in human cancer cell lines
    • Paz M., Fraga M., Avila S., Guo M., Pollan M., Herman J., et al. A systematic profile of DNA methylation in human cancer cell lines. Cancer Res 63 (2003) 1114-1121
    • (2003) Cancer Res , vol.63 , pp. 1114-1121
    • Paz, M.1    Fraga, M.2    Avila, S.3    Guo, M.4    Pollan, M.5    Herman, J.6
  • 46
    • 0030742476 scopus 로고    scopus 로고
    • Flow cytometric DNA hypertetraploidy is associated with unfavourable prognostic features in breast cancer
    • Pinto A., Andre S., Nogueira M., Mendonca E., and Soares J. Flow cytometric DNA hypertetraploidy is associated with unfavourable prognostic features in breast cancer. J Clin Pathol 50 (1997) 591-595
    • (1997) J Clin Pathol , vol.50 , pp. 591-595
    • Pinto, A.1    Andre, S.2    Nogueira, M.3    Mendonca, E.4    Soares, J.5
  • 47
    • 22044453076 scopus 로고    scopus 로고
    • DNA flow cytrometry in solid tumors
    • Pinto A., Fonseca I., and Soares J. DNA flow cytrometry in solid tumors. Acta Med Port 15 (2002) 133-142
    • (2002) Acta Med Port , vol.15 , pp. 133-142
    • Pinto, A.1    Fonseca, I.2    Soares, J.3
  • 48
    • 1842614152 scopus 로고    scopus 로고
    • Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissue
    • Pogribny I., James S., Jemigan S., and Pogribna M. Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissue. Mutation Res 548 (2004) 53-59
    • (2004) Mutation Res , vol.548 , pp. 53-59
    • Pogribny, I.1    James, S.2    Jemigan, S.3    Pogribna, M.4
  • 49
    • 30944437615 scopus 로고    scopus 로고
    • Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency
    • Pogribny I., Ross S., Wise C., Pogribna M., Jones E., Tryndyak V., et al. Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutation Res 593 (2006) 80-87
    • (2006) Mutation Res , vol.593 , pp. 80-87
    • Pogribny, I.1    Ross, S.2    Wise, C.3    Pogribna, M.4    Jones, E.5    Tryndyak, V.6
  • 50
    • 0035902166 scopus 로고    scopus 로고
    • Cancer genetics
    • Ponder B.A. Cancer genetics. Nature 411 (2001) 336-341
    • (2001) Nature , vol.411 , pp. 336-341
    • Ponder, B.A.1
  • 51
    • 0001992028 scopus 로고    scopus 로고
    • Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential
    • Qu G., Dubeau L., Narayan A., Yu M., and Ehrlich M. Satellite DNA hypomethylation vs. overall genomic hypomethylation in ovarian epithelial tumors of different malignant potential. Mutation Res 423 (1999) 91-101
    • (1999) Mutation Res , vol.423 , pp. 91-101
    • Qu, G.1    Dubeau, L.2    Narayan, A.3    Yu, M.4    Ehrlich, M.5
  • 52
    • 0034720284 scopus 로고    scopus 로고
    • CpG methylation is maintained in human cancer cells lacking DNMT1
    • Rhee I., Jair K., Yen R., Lengauer C., Herman J., Kinzle K., et al. CpG methylation is maintained in human cancer cells lacking DNMT1. Nature (London) 404 (2000) 1003-1007
    • (2000) Nature (London) , vol.404 , pp. 1003-1007
    • Rhee, I.1    Jair, K.2    Yen, R.3    Lengauer, C.4    Herman, J.5    Kinzle, K.6
  • 53
    • 0037068372 scopus 로고    scopus 로고
    • DNA methylation and chromatin
    • Robertson K. DNA methylation and chromatin. Oncogene 21 (2002) 5361-5379
    • (2002) Oncogene , vol.21 , pp. 5361-5379
    • Robertson, K.1
  • 54
    • 33749037187 scopus 로고    scopus 로고
    • Chromosome instability correlates with genome-wide DNA demethylation in human primary colorectal cancer
    • Rodriguez J., Fridola J., Vendrell E., Risques R.-A., Fraga M., Morales C., et al. Chromosome instability correlates with genome-wide DNA demethylation in human primary colorectal cancer. Cancer Res 66 (2006) 8462-8468
    • (2006) Cancer Res , vol.66 , pp. 8462-8468
    • Rodriguez, J.1    Fridola, J.2    Vendrell, E.3    Risques, R.-A.4    Fraga, M.5    Morales, C.6
  • 55
    • 0035962632 scopus 로고    scopus 로고
    • DNA methylation, chromatin inheritance, and cancer
    • Rountree M., Bachman K., Herman J., and Baylin S. DNA methylation, chromatin inheritance, and cancer. Oncogene 20 (2001) 3156-3165
    • (2001) Oncogene , vol.20 , pp. 3156-3165
    • Rountree, M.1    Bachman, K.2    Herman, J.3    Baylin, S.4
  • 56
    • 33847317873 scopus 로고    scopus 로고
    • DNA methylation in health, disease, and cancer
    • Shames D., Minna J., and Gazdar A. DNA methylation in health, disease, and cancer. Curr Mol Med 7 (2007) 85-102
    • (2007) Curr Mol Med , vol.7 , pp. 85-102
    • Shames, D.1    Minna, J.2    Gazdar, A.3
  • 57
    • 0842346437 scopus 로고    scopus 로고
    • Principles of tumor suppression
    • Sherr C. Principles of tumor suppression. Cell 116 (2004) 235-246
    • (2004) Cell , vol.116 , pp. 235-246
    • Sherr, C.1
  • 58
    • 53649102380 scopus 로고    scopus 로고
    • The correlation relationships between cancer-associated pattern genome DNA hypomethylation and mitotic interphase nuclear heterochromatinization contributing to carcinogenesis
    • (Ukraine)
    • Shvachko L. The correlation relationships between cancer-associated pattern genome DNA hypomethylation and mitotic interphase nuclear heterochromatinization contributing to carcinogenesis. Proc Biol Med 2 (2008) 38-45 (Ukraine)
    • (2008) Proc Biol Med , vol.2 , pp. 38-45
    • Shvachko, L.1
  • 62
    • 0034524531 scopus 로고    scopus 로고
    • Somatic mutation theory of carcinogenesis: why it should be dropped and replaced
    • Sonnenschein C., and Soto A. Somatic mutation theory of carcinogenesis: why it should be dropped and replaced. Mol Carcinog 29 (2001) 205-211
    • (2001) Mol Carcinog , vol.29 , pp. 205-211
    • Sonnenschein, C.1    Soto, A.2
  • 63
    • 7044264244 scopus 로고    scopus 로고
    • Problems and paradigms. The somatic mutation theory of cancer: growing problems with the paradigm?
    • Soto A., and Sonnenschein C. Problems and paradigms. The somatic mutation theory of cancer: growing problems with the paradigm?. BioEssays 26 (2004) 1097-1107
    • (2004) BioEssays , vol.26 , pp. 1097-1107
    • Soto, A.1    Sonnenschein, C.2
  • 64
    • 68049110570 scopus 로고    scopus 로고
    • Stefanova V, Chyryaeva O, Smirnov A. The influence of 5-azacytidine on the structure-function organization of mitotic chromosomes. IV All-Union symposium Molecular mechanisms of genetics processes. 3-6 February, Moscow, Proceedings; 1987. p. 49 (Russian).
    • Stefanova V, Chyryaeva O, Smirnov A. The influence of 5-azacytidine on the structure-function organization of mitotic chromosomes. IV All-Union symposium "Molecular mechanisms of genetics processes". 3-6 February, Moscow, Proceedings; 1987. p. 49 (Russian).
  • 65
    • 85047687069 scopus 로고    scopus 로고
    • Therapeutic implications of DNA methylation
    • Szif M. Therapeutic implications of DNA methylation. Future Oncol 1 (2005) 125-135
    • (2005) Future Oncol , vol.1 , pp. 125-135
    • Szif, M.1
  • 66
    • 21544472099 scopus 로고    scopus 로고
    • DNA methylation and demethylation as targets for anticancer therapy
    • Szyf M. DNA methylation and demethylation as targets for anticancer therapy. Biochemistry (Moscow) 70 (2005) 533-549
    • (2005) Biochemistry (Moscow) , vol.70 , pp. 533-549
    • Szyf, M.1
  • 67
    • 33749070191 scopus 로고    scopus 로고
    • Targeting DNA methylation in cancer
    • Szyf M. Targeting DNA methylation in cancer. Bull Cancer 93 (2006) 961-972
    • (2006) Bull Cancer , vol.93 , pp. 961-972
    • Szyf, M.1
  • 68
    • 3042658499 scopus 로고    scopus 로고
    • DNA demethylation and cancer: therapeutic implications
    • Szyf M., Pakneshan P., and Rabbani S. DNA demethylation and cancer: therapeutic implications. Cancer Lett 211 (2004) 133-143
    • (2004) Cancer Lett , vol.211 , pp. 133-143
    • Szyf, M.1    Pakneshan, P.2    Rabbani, S.3
  • 69
    • 0036900330 scopus 로고    scopus 로고
    • Epigenetics in cancer: implications for early detection and prevention
    • Verma M., and Srivastava S. Epigenetics in cancer: implications for early detection and prevention. Lancet Oncol 3 (2002) 755-763
    • (2002) Lancet Oncol , vol.3 , pp. 755-763
    • Verma, M.1    Srivastava, S.2
  • 70
    • 0034929515 scopus 로고    scopus 로고
    • DNA methylation: an alternative pathway to cancer
    • Wajed S., Laird P., and DeMeester T. DNA methylation: an alternative pathway to cancer. Ann Surg 234 (2001) 10-20
    • (2001) Ann Surg , vol.234 , pp. 10-20
    • Wajed, S.1    Laird, P.2    DeMeester, T.3
  • 72
    • 0036735638 scopus 로고    scopus 로고
    • DNA methylation: an epigenetic pathway to cancer and a promising target for anticancer therapy
    • Worm J., and Guldberg P. DNA methylation: an epigenetic pathway to cancer and a promising target for anticancer therapy. J Oral Pathol Med 31 (2002) 443-449
    • (2002) J Oral Pathol Med , vol.31 , pp. 443-449
    • Worm, J.1    Guldberg, P.2
  • 73
    • 0033547330 scopus 로고    scopus 로고
    • Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
    • Xu G., Bestor T., Bourc'his D., Hsieh C., Tommerup N., Bugge M., et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature (London) 402 (1999) 187-191
    • (1999) Nature (London) , vol.402 , pp. 187-191
    • Xu, G.1    Bestor, T.2    Bourc'his, D.3    Hsieh, C.4    Tommerup, N.5    Bugge, M.6
  • 74
    • 68049084816 scopus 로고
    • The chromomere organization of polytene chromosomes
    • (Russian)
    • Zhimulev I. The chromomere organization of polytene chromosomes. Novosybirsk VO Science (1994) 565 (Russian)
    • (1994) Novosybirsk VO Science , pp. 565
    • Zhimulev, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.