Promoter-region hypermethylation and gene silencing in human cancer

Current Topics in Microbiology and Immunology

Volumn 249, Issue , 2000, Pages 35-54

  Herman, J G ^a   Baylin, S B ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR MARKER;

CHROMATIN; DNA METHYLATION; ENZYME ACTIVITY; GENE FUNCTION; GENE SILENCING; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; TUMOR CELL;

EID: 0034095131     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-59696-4_3     Document Type: Review

References (9)

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2. Ahuja A, Mohan AL, Li Q, Stolker JM, Herman JG, Hamilton SR, Baylin SB, Issa J-P (1997) Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res 57:3370-3374
3. Ahuja A, Li Q, Mohan AL, Baylin SB, Issa J-P (1998) Aging and DNA methylation in colorectal mucosa and cancer. Cancer Research 58:5489-5494
4. Antequera F, Bird A (1993) CpG islands. In: DNA methylation: molecular biology and biological significance, Jost JP, Saluz HP (eds) (Basel: Birkhauser Verlag), pp 169-185
5. Antequera F, Boyes J, Bird A (1990) High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell 62:503-514
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7. Bakin AV, Curran T (1999) Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science 283:387-390
8. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa J-P (1998) Alterations in DNA methylation: a fundamental aspect of neoplasia: In Advances in Cancer Research, Klein G, Van de Woude GF (eds) (San Diego: Academic Press), pp 141-196
9. Beard C, Li E, Jaenisch R (1995) Loss of methylation activates Xist in somatic but not in embryonic cells. Genes and Dev 9:2325-2334