A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms

Biochemistry

Volumn 44, Issue 12, 2005, Pages 4676-4690

  Wang, Zhi Qiang ^a   Wei, Chin Chuan ^a   Santolini, Jerome ^a   Panda, Koustubh ^a   Wang, Qian ^a   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DIMERIZATION; ELECTRON TRANSITIONS; NITROGEN OXIDES; PROTEINS; PURIFICATION; REDUCTION;

HEME; ISOZYMES; MUTANTS; NITRIC OXIDE SYNTHASES (NOS);

ENZYMES;

CARBON MONOXIDE; FERRIC ION; FERROUS ION; HEME; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROBIOPTERIN; TRYPTOPHAN;

ARTICLE; CATALYSIS; COMPLEX FORMATION; DIMERIZATION; ELECTRON TRANSPORT; ENZYME ACTIVITY; OXIDATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SOLUBILITY; SYNTHESIS;

ANIMALS; ARGININE; BIOPTERIN; CATALYSIS; DIMERIZATION; ELECTRON TRANSPORT; ENZYME STABILITY; FERROUS COMPOUNDS; HEME; HYDROXYLATION; ISOENZYMES; KINETICS; MICE; MUTAGENESIS, SITE-DIRECTED; NADP; NERVE TISSUE PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; OXIDATION-REDUCTION; PROTEIN BINDING; RATS; SPECTROPHOTOMETRY; TRYPTOPHAN;

EID: 15444375706     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047508p     Document Type: Article

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