Stem Cell Therapy: A Primer for Interventionalists and Imagers

Journal of Vascular and Interventional Radiology

Volumn 20, Issue 8, 2009, Pages 999-1012

  Nikolic, Boris ^a   Faintuch, Salomao ^a   Goldberg, S Nahum ^a   Kuo, Michael D ^b   Cardella, John F ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GEISINGER HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN; GADOLINIUM; INDIUM 111; IODINE 123; TECHNETIUM 99M; TETROFOSMIN TC 99M;

ARTERY DISEASE; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL ASSESSMENT; CLINICAL STUDY; DIABETES MELLITUS; DIAGNOSTIC IMAGING; DRUG DELIVERY SYSTEM; ENGRAFTMENT; EXPERT SYSTEM; HUMAN; INTERVENTIONAL RADIOLOGY; LIVER DISEASE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PATIENT CARE; PATIENT MONITORING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOLOGIST; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STEM CELL TRANSPLANTATION; STROKE;

ANGIOGRAPHY; RADIOLOGY, INTERVENTIONAL; STEM CELL TRANSPLANTATION; SURGERY, COMPUTER-ASSISTED; VASCULAR SURGICAL PROCEDURES;

EID: 67749088298     PISSN: 10510443     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvir.2009.04.075     Document Type: Article

References (171)

1. Muraca M., Galbiati G., Vilei M.T., Coelho Fabricio A.S., and Caruso M. The future of stem cells in liver diseases. Ann Hepatol 5 (2006) 68-76
2. Oertel M., and Shafritz D.A. Stem cells, cell transplantation and liver repopulation. Biochim Biophys Acta 1782 (2008) 61-74
3. Takahashi K., Tanabe K., Ohnuki M., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131 (2007) 861-872
4. Yu J., Vodyanik M.A., Smuga-Otto K., et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 318 (2007) 1917-1920
5. Samavedi V., Sacher R.A., Efiom-Ekaha D., Patel A.G., Kuku A., and Ladapo A. Hematopoietic stem cell transplantation. http://www.emedicine.com/med/byname/Hematopoietic-Stem-Cell-Transplantat ion.htm Accessed June 25, 2009
6. Farquhar C., Marjoribanks J., Basser R., and Lethaby A. High dose chemotherapy and autologous bone marrow or stem cell transplantation versus conventional chemotherapy for women with early poor prognosis breast cancer. Cochrane Database Syst Rev 20 (2005) CD003139
7. Farquhar C.M., Marjoribanks J., Lethaby A., and Basser R. High dose chemotherapy for poor prognosis breast cancer: systematic review and meta-analysis. Cancer Treat Rev 33 (2007) 325-337
8. Takahashi M., Nakamura T., Toba T., Kajiwara N., Kato H., and Shimizu Y. Transplantation of endothelial progenitor cells into the lung to alleviate pulmonary hypertension in dogs. Tissue Eng 10 (2004) 771-779
9. Lagasse E., Connors H., Al-Dhalimy M., et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Natl Med 6 (2000) 1229-1234
10. Yamamoto H., Quinn G., Asari A., et al. Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology 37 (2003) 983-993
11. Bai H., and Wang Z.Z. Directing human embryonic stem cells to generate vascular progenitor cells. Gene Ther 15 (2008) 89-95
12. Fiegel H.C., Lioznov M.V., Cortes-Dericks L., et al. Liver-specific gene expression in cultured human hematopoietic stem cells. Stem Cells 21 (2003) 98-104
13. Heine W., Conant K., Griffin J.W., and Hoke A. Transplanted neural stem cells promote axonal regeneration through chronically denervated peripheral nerves. Exp Neurol 189 (2004) 231-240
14. Kim B.G., Hwang D.H., Lee S.I., Kim E.J., and Kim S.U. Stem cell-based cell therapy for spinal cord injury. Cell Transplant 16 (2007) 355-364
15. Karussis D., and Kassis I. The potential use of stem cells in multiple sclerosis: an overview of the preclinical experience. Clin Neurol Neurosurg 110 (2008) 889-896
16. Sugaya K., Kwak Y.D., Ohmitsu O., Marutle A., Greig N.H., and Choumrina E. Practical issues in stem cell therapy for Alzheimer's disease. Curr Alzheimer Res 4 (2007) 370-377
17. Christou Y.A., Moore H.D., Shaw P.J., and Monk P.N. Embryonic stem cells and prospects for their use in regenerative medicine approaches to motor neurone disease. Neuropathol Appl Neurobiol 33 (2007) 485-498
18. Korecka J.A., Verhaagen J., and Hol E.M. Cell-replacement and gene-therapy strategies for Parkinson's and Alzheimer's disease. Regen Med 2 (2007) 425-446
19. Guzman R., De Los Angeles A., Cheshier S., et al. Intracarotid injection of fluorescence activated cell-sorted CD49d-positive neural stem cells improves targeted cell delivery and behavior after stroke in a mouse stroke model. Stroke 39 (2008) 1300-1306
20. Walczak P., Zhang J., Gilad A.A., et al. Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke 39 (2008) 1569-1574
21. Mendez-Otero R., de Freitas G.R., Andre C., de Mendonca M.L., Friedrich M., and Oliveira-Filho J. Potential roles of bone marrow stem cells in stroke therapy. Regen Med 2 (2007) 417-423
22. Burt R.K., Cohen B., Rose J., et al. Hematopoietic stem cell transplantation for multiple sclerosis. Arch Neurol 62 (2005) 860-864
23. Uccelli A., Zappia E., Benvenuto F., Frassoni F., and Mancardi G. Stem cells in inflammatory demyelinating disorders: a dual role for immunosuppression and neuroprotection. Expert Opin Biol Ther 6 (2006) 17-22
24. Pluchino S., Quattrini A., Brambilla E., et al. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 422 (2003) 688-694
25. Granero-Molto F., Weis J.A., Longobardi L., and Spagnoli A. Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repair. Expert Opin Biol Ther 8 (2008) 255-268
26. Salgado A.J., Oliveira J.T., Pedro A.J., and Reis R.L. Adult stem cells in bone and cartilage tissue engineering. Curr Stem Cell Res Ther 1 (2006) 345-364
27. Butler D.L., Juncosa-Melvin N., Boivin G.P., et al. Functional tissue engineering for tendon repair: a multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation. J Orthop Res 26 (2008) 1-9
28. Richter W. Cell-based cartilage repair: illusion or solution for osteoarthritis. Curr Opin Rheumatol 19 (2007) 451-456
29. Gulati R., and Simari R.D. Cell therapy for acute myocardial infarction. Med Clin North Am 91 (2007) 769-785 xiii
30. Segers V.F., and Lee R.T. Stem-cell therapy for cardiac disease. Nature 451 (2008) 937-942
31. Nonome K., Li X.K., Takahara T., et al. Human umbilical cord blood-derived cells differentiate into hepatocyte-like cells in the Fas-mediated liver injury model. Am J Physiol Gastrointest Liver Physiol 289 (2005) G1091-G1099
32. Agarwal S., Holton K.L., and Lanza R. Efficient differentiation of functional hepatocytes from human embryonic stem cells. Stem Cells 26 (2008) 1117-1127
33. Yin Y., Lim Y.K., Salto-Tellez M., Ng S.C., Lin C.S., and Lim S.K. AFP(+), ESC-derived cells engraft and differentiate into hepatocytes in vivo. Stem Cells 20 (2002) 338-346
34. Abdel Aziz M.T., Atta H.M., Mahfouz S., et al. Therapeutic potential of bone marrow-derived mesenchymal stem cells on experimental liver fibrosis. Clin Biochem 40 (2007) 893-899
35. Fiegel H.C., Lange C., Kneser U., et al. Fetal and adult liver stem cells for liver regeneration and tissue engineering. J Cell Mol Med 10 (2006) 577-587
36. Palma C.A., Lindeman R., and Tuch B.E. Blood into beta-cells: can adult stem cells be used as a therapy for Type 1 diabetes?. Regen Med 3 (2008) 33-47
37. Hardikar A.A., Lees J.G., Sidhu K.S., Colvin E., and Tuch B.E. Stem-cell therapy for diabetes cure: how close are we?. Curr Stem Cell Res Ther 1 (2006) 425-436
38. Burns C.J., Persaud S.J., and Jones P.M. Diabetes mellitus: a potential target for stem cell therapy. Curr Stem Cell Res Ther 1 (2006) 255-266
39. Seissler J., and Schott M. Generation of insulin-producing beta cells from stem cells-perspectives for cell therapy in type 1 diabetes. Horm Metab Res 40 (2008) 155-161
40. Lee D.D., Grossman E., and Chong A.S. Cellular therapies for type 1 diabetes. Horm Metab Res 40 (2008) 147-154
41. Iskovich S., Kaminitz A., Yafe M.P., et al. Participation of adult bone marrow-derived stem cells in pancreatic regeneration: neogenesis versus endogenesis. Curr Stem Cell Res Ther 2 (2007) 272-279
42. Hussain M.A., and Theise N.D. Stem-cell therapy for diabetes mellitus. Lancet 364 (2004) 203-205
43. Soria B., Skoudy A., and Martin F. From stem cells to beta cells: new strategies in cell therapy of diabetes mellitus. Diabetologia 44 (2001) 407-415
44. Blyszczuk P., Czyz J., Kania G., et al. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci U S A 100 (2003) 998-1003
45. Hori Y., Rulifson I.C., Tsai B.C., Heit J.J., Cahoy J.D., and Kim S.K. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A 99 (2002) 16105-16110
46. Sprengers R.W., Lips D.J., Moll F.L., and Verhaar M.C. Progenitor cell therapy in patients with critical limb ischemia without surgical options. Ann Surg 247 (2008) 411-420
47. Velazquez O.C. Angiogenesis and vasculogenesis: inducing the growth of new blood vessels and wound healing by stimulation of bone marrow-derived progenitor cell mobilization and homing. J Vasc Surg 45 suppl A (2007) A39-A47
48. Nikol S. Therapeutic angiogenesis for peripheral artery disease: gene therapy. Vasa 36 (2007) 165-173
49. Sepulveda P., Martinez-Leon J., and Garcia-Verdugo J.M. Neoangiogenesis with endothelial precursors for the treatment of ischemia. Transplant Proc 39 (2007) 2089-2094
50. Loebinger M.R., Aguilar S., and Janes S.M. Therapeutic potential of stem cells in lung disease: progress and pitfalls. Clin Sci (Lond) 114 (2008) 99-108
51. Lenssen J., and Stolk J. Pulmonary stem cells and the induction of tissue regeneration in the treatment of emphysema. Int J Chron Obstruct Pulmon Dis 2 (2007) 131-139
52. Loebinger M.R., and Janes S.M. Stem cells for lung disease. Chest 132 (2007) 279-285
53. Yan X., Liu Y., Han Q., et al. Injured microenvironment directly guides the differentiation of engrafted Flk-1(+) mesenchymal stem cell in lung. Exp Hematol 35 (2007) 1466-1475
54. Tyndall A., and Furst D.E. Adult stem cell treatment of scleroderma. Curr Opin Rheumatol 19 (2007) 604-610
55. Tongers J., and Losordo D.W. Frontiers in nephrology: the evolving therapeutic applications of endothelial progenitor cells. J Am Soc Nephrol 18 (2007) 2843-2852
56. Gaillard F., and Sauve Y. Cell-based therapy for retina degeneration: the promise of a cure. Vision Res 47 (2007) 2815-2824
57. Lin J., Feng L., Fukudome S., Hamajima Y., Huang T., and Levine S. Cochlear stem cells/progenitors and degenerative hearing disorders. Curr Med Chem 14 (2007) 2937-2943
58. Atkinson K., Nivison-Smith I., and Hawkins T. Haemopoietic stem cell transplantation in Australia, 1992-95: a report from the Australian Bone Marrow Transplant Recipient Registry. Aust N Z J Med 27 (1997) 408-419
59. Owen R.J., Ryan E.A., O'Kelly K., et al. Percutaneous transhepatic pancreatic islet cell transplantation in type 1 diabetes mellitus: radiologic aspects. Radiology 229 (2003) 165-170
60. Strauer B.E., Brehm M., and Schannwell C.M. The therapeutic potential of stem cells in heart disease. Cell Prolif 41 suppl 1 (2008) S126-S145
61. Taguchi A., Soma T., Tanaka H., et al. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model. J Clin Invest 114 (2004) 330-338
62. Shah K., Bureau E., Kim D.E., et al. Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol 57 (2005) 34-41
63. Laird D.J., von Andrian U.H., and Wagers A.J. Stem cell trafficking in tissue development, growth, and disease. Cell 132 (2008) 612-630
64. Allen K.J., Buck N.E., and Williamson R. Stem cells for the treatment of liver disease. Transpl Immunol 15 (2005) 99-112
65. Furst G., Schulte am Esch J., Poll L.W., et al. Portal vein embolization and autologous CD133+ bone marrow stem cells for liver regeneration: initial experience. Radiology 243 (2007) 171-179
66. Wagers A.J., Sherwood R.I., Christensen J.L., and Weissman I.L. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 297 (2002) 2256-2259
67. Dahlke M.H., Popp F.C., Bahlmann F.H., et al. Liver regeneration in a retrorsine/CCl4-induced acute liver failure model: do bone marrow-derived cells contribute?. J Hepatol 39 (2003) 365-373
68. Krause D.S., Theise N.D., Collector M.I., et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105 (2001) 369-377
69. Bird T.G., Lorenzini S., and Forbes S.J. Activation of stem cells in hepatic diseases. Cell Tissue Res 331 (2008) 283-300
70. Leone A.M., Rutella S., Bonanno G., et al. Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J 26 (2005) 1196-1204
71. Bos C., Delmas Y., Desmouliere A., et al. In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver. Radiology 233 (2004) 781-789
72. Hauger O., Frost E.E., van Heeswijk R., et al. MR evaluation of the glomerular homing of magnetically labeled mesenchymal stem cells in a rat model of nephropathy. Radiology 238 (2006) 200-210
73. Sykova E., and Jendelova P. Magnetic resonance tracking of transplanted stem cells in rat brain and spinal cord. Neurodegener Dis 3 (2006) 62-67
74. Modo M., Mellodew K., Cash D., et al. Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study. Neuroimage 21 (2004) 311-317
75. Hoehn M., Kustermann E., Blunk J., et al. Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proc Natl Acad Sci U S A 99 (2002) 16267-16272
76. Jendelova P., Herynek V., DeCroos J., et al. Imaging the fate of implanted bone marrow stromal cells labeled with superparamagnetic nanoparticles. Magn Reson Med 50 (2003) 767-776
77. Jendelova P., Herynek V., Urdzikova L., et al. Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord. J Neurosci Res 76 (2004) 232-243
78. Sykova E., and Jendelova P. Magnetic resonance tracking of implanted adult and embryonic stem cells in injured brain and spinal cord. Ann N Y Acad Sci 1049 (2005) 146-160
79. Daldrup-Link H.E., Rudelius M., Piontek G., et al. Migration of iron oxide-labeled human hematopoietic progenitor cells in a mouse model: in vivo monitoring with 1.5-T MR imaging equipment. Radiology 234 (2005) 197-205
80. Ju S., Teng G.J., Lu H., et al. In vivo MR tracking of mesenchymal stem cells in rat liver after intrasplenic transplantation. Radiology 245 (2007) 206-215
81. Cao Y.A., Wagers A.J., Beilhack A., et al. Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A 101 (2004) 221-226
82. Wu J.C., Chen I.Y., Sundaresan G., et al. Molecular imaging of cardiac cell transplantation in living animals using optical bioluminescence and positron emission tomography. Circulation 108 (2003) 1302-1305
83. Tang Y., Shah K., Messerli S.M., Snyder E., Breakefield X., and Weissleder R. In vivo tracking of neural progenitor cell migration to glioblastomas. Hum Gene Ther 14 (2003) 1247-1254
84. Rice B.W., Cable M.D., and Nelson M.B. In vivo imaging of light-emitting probes. J Biomed Opt 6 (2001) 432-440
85. Rudin M., Rausch M., and Stoeckli M. Molecular imaging in drug discovery and development: potential and limitations of nonnuclear methods. Mol Imaging Biol 7 (2005) 5-13
86. Frangioni J.V. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol 7 (2003) 626-634
87. Hoshino K., Ly H.Q., Frangioni J.V., and Hajjar R.J. In vivo tracking in cardiac stem cell-based therapy. Prog Cardiovasc Dis 49 (2007) 414-420
88. Gao J., Dennis J.E., Muzic R.F., Lundberg M., and Caplan A.I. The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion. Cells Tissues Organs 169 (2001) 12-20
89. Chin B.B., Nakamoto Y., Bulte J.W., Pittenger M.F., Wahl R., and Kraitchman D.L. 111In oxine labelled mesenchymal stem cell SPECT after intravenous administration in myocardial infarction. Nucl Med Commun 24 (2003) 1149-1154
90. Barbash I.M., Chouraqui P., Baron J., et al. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 108 (2003) 863-868
91. Aicher A., Brenner W., Zuhayra M., et al. Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation 107 (2003) 2134-2139
92. Gambhir S.S., Herschman H.R., Cherry S.R., et al. Imaging transgene expression with radionuclide imaging technologies. Neoplasia 2 (2000) 118-138
93. Simonova M., Shtanko O., Sergeyev N., Weissleder R., and Bogdanov Jr. A. Engineering of technetium-99m-binding artificial receptors for imaging gene expression. J Gene Med 5 (2003) 1056-1066
94. MacLaren D.C., Toyokuni T., Cherry S.R., et al. PET imaging of transgene expression. Biol Psychiatry 48 (2000) 337-348
95. Chemaly E.R., Yoneyama R., Frangioni J.V., and Hajjar R.J. Tracking stem cells in the cardiovascular system. Trends Cardiovasc Med 15 (2005) 297-302
96. Amado L.C., Saliaris A.P., Schuleri K.H., et al. Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci U S A 102 (2005) 11474-11479
97. Kraitchman D.L., Heldman A.W., Atalar E., et al. In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction. Circulation 107 (2003) 2290-2293
98. Wickline S.A., and Lanza G.M. Nanotechnology for molecular imaging and targeted therapy. Circulation 107 (2003) 1092-1095
99. Modo M., Cash D., Mellodew K., et al. Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging. Neuroimage 17 (2002) 803-811
100. Al-Hajj M., Wicha M.S., Benito-Hernandez A., Morrison S.J., and Clarke M.F. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 100 (2003) 3983-3988
101. Singh S.K., Clarke I.D., Terasaki M., et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 63 (2003) 5821-5828
102. O'Brien C.A., Pollett A., Gallinger S., and Dick J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445 (2007) 106-110
103. Li C., Heidt D.G., Dalerba P., et al. Identification of pancreatic cancer stem cells. Cancer Res 67 (2007) 1030-1037
104. Rhim J.A., Sandgren E.P., Degen J.L., Palmiter R.D., and Brinster R.L. Replacement of diseased mouse liver by hepatic cell transplantation. Science 263 (1994) 1149-1152
105. Overturf K., al-Dhalimy M., Ou C.N., Finegold M., and Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol 151 (1997) 1273-1280
106. Jang Y.Y., Collector M.I., Baylin S.B., Diehl A.M., and Sharkis S.J. Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol 6 (2004) 532-539
107. Cantz T., Sharma A.D., Jochheim-Richter A., et al. Reevaluation of bone marrow-derived cells as a source for hepatocyte regeneration. Cell Transplant 13 (2004) 659-666
108. Lysy P.A., Campard D., Smets F., Najimi M., and Sokal E.M. Stem cells for liver tissue repair: current knowledge and perspectives. World J Gastroenterol 14 (2008) 864-875
109. Khuu D.N., Najimi M., and Sokal E.M. Epithelial cells with hepatobiliary phenotype: is it another stem cell candidate for healthy adult human liver?. World J Gastroenterol 13 (2007) 1554-1560
110. Najimi M., Khuu D.N., Lysy P.A., et al. Adult-derived human liver mesenchymal-like cells as a potential progenitor reservoir of hepatocytes?. Cell Transplant 16 (2007) 717-728
111. Sidler Pfandler M.A., Hochli M., Inderbitzin D., Meier P.J., and Stieger B. Small hepatocytes in culture develop polarized transporter expression and differentiation. J Cell Sci 117 (2004) 4077-4087
112. Kobayashi N., Ando M., Kosaka Y., et al. Partial hepatectomy and subsequent radiation facilitates engraftment of mouse embryonic stem cells in the liver. Transplant Proc 36 (2004) 2352-2354
113. Nikolic B., Elisa M., and Mertyna P. Yam S, Goldberg SN. The effect of hepatic radiofrequency ablation on stem cell trafficking in the rat model. J Vasc Interv Radiol 20 (2009) 640-647
114. Passier R., van Laake L.W., and Mummery C.L. Stem-cell-based therapy and lessons from the heart. Nature 453 (2008) 322-329
115. Orlic D., Kajstura J., Chimenti S., et al. Bone marrow cells regenerate infarcted myocardium. Nature 410 (2001) 701-705
116. Cintron G., Johnson G., Francis G., Cobb F., and Cohn J.N. Prognostic significance of serial changes in left ventricular ejection fraction in patients with congestive heart failure: the V-HeFT VA Cooperative Studies Group. Circulation 87 (1993) VI17-VI23
117. Adler E.D., and Maddox T.M. Cell therapy for cardiac disease: where do we go from here?. Nat Clin Pract Cardiovasc Med 4 (2007) 2-3
118. Murry C.E., Soonpaa M.H., Reinecke H., et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428 (2004) 664-668
119. Balsam L.B., Wagers A.J., Christensen J.L., Kofidis T., Weissman I.L., and Robbins R.C. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428 (2004) 668-673
120. Janssens S., Dubois C., Bogaert J., et al. Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet 367 (2006) 113-121
121. Kehat I., Khimovich L., Caspi O., et al. Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 22 (2004) 1282-1289
122. Xue T., Cho H.C., Akar F.G., et al. Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers. Circulation 111 (2005) 11-20
123. Moelker A.D., Baks T., Wever K.M., et al. Intracoronary delivery of umbilical cord blood derived unrestricted somatic stem cells is not suitable to improve LV function after myocardial infarction in swine. J Mol Cell Cardiol 42 (2007) 735-745
124. Hooi J.D., Stoffers H.E., Knottnerus J.A., and van Ree J.W. The prognosis of non-critical limb ischaemia: a systematic review of population-based evidence. Br J Gen Pract 49 (1999) 49-55
125. Albers M., Fratezi A.C., and De Luccia N. Assessment of quality of life of patients with severe ischemia as a result of infrainguinal arterial occlusive disease. J Vasc Surg 16 (1992) 54-59
126. Dormandy J., Heeck L., and Vig S. Predicting which patients will develop chronic critical leg ischemia. Semin Vasc Surg 12 (1999) 138-141
127. Valentine R.J., Myers S.I., Inman M.H., Roberts J.R., and Clagett G.P. Late outcome of amputees with premature atherosclerosis. Surgery 119 (1996) 487-493
128. Guidelines for percutaneous transluminal angioplasty. Standards of Practice Committee of the Society of Cardiovascular and Interventional Radiology. Radiology 177 (1990) 619-626
129. Tateishi-Yuyama E., Matsubara H., Murohara T., et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 360 (2002) 427-435
130. Esato K., Hamano K., Li T.S., et al. Neovascularization induced by autologous bone marrow cell implantation in peripheral arterial disease. Cell Transplant 11 (2002) 747-752
131. Higashi Y., Kimura M., Hara K., et al. Autologous bone-marrow mononuclear cell implantation improves endothelium-dependent vasodilation in patients with limb ischemia. Circulation 109 (2004) 1215-1218
132. Miyamoto M., Yasutake M., Takano H., et al. Therapeutic angiogenesis by autologous bone marrow cell implantation for refractory chronic peripheral arterial disease using assessment of neovascularization by 99mTc-tetrofosmin (TF) perfusion scintigraphy. Cell Transplant 13 (2004) 429-437
133. Saigawa T., Kato K., Ozawa T., et al. Clinical application of bone marrow implantation in patients with arteriosclerosis obliterans, and the association between efficacy and the number of implanted bone marrow cells. Circ J 68 (2004) 1189-1193
134. Bartsch T., Falke T., Brehm M., et al. Transplantation of autologous adult bone marrow stem cells in patients with severe peripheral arterial occlusion disease [in German]. Med Klin (Munich) 101 suppl 1 (2006) S195-S197
135. Durdu S., Akar A.R., Arat M., Sancak T., Eren N.T., and Ozyurda U. Autologous bone-marrow mononuclear cell implantation for patients with Rutherford grade II-III thromboangiitis obliterans. J Vasc Surg 44 (2006) 732-739
136. Miyamoto K., Nishigami K., Nagaya N., et al. Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangiitis obliterans. Circulation 114 (2006) 2679-2684
137. Kajiguchi M., Kondo T., Izawa H., et al. Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia. Circ J 71 (2007) 196-201
138. Huang P., Li S., Han M., Xiao Z., Yang R., and Han Z.C. Autologous transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells improves critical limb ischemia in diabetes. Diabetes Care 28 (2005) 2155-2160
139. Doetsch F. The glial identity of neural stem cells. Nat Neurosci 6 (2003) 1127-1134
140. Alvarez-Buylla A., Seri B., and Doetsch F. Identification of neural stem cells in the adult vertebrate brain. Brain Res Bull 57 (2002) 751-758
141. Hess D.C., and Borlongan C.V. Stem cells and neurological diseases. Cell Prolif 41 suppl 1 (2008) S94-S114
142. Cogle C.R., Yachnis A.T., Laywell E.D., et al. Bone marrow transdifferentiation in brain after transplantation: a retrospective study. Lancet 363 (2004) 1432-1437
143. Mezey E., Key S., Vogelsang G., Szalayova I., Lange G.D., and Crain B. Transplanted bone marrow generates new neurons in human brains. Proc Natl Acad Sci U S A 100 (2003) 1364-1369
144. Kawada H., Takizawa S., Takanashi T., et al. Administration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells. Circulation 113 (2006) 701-710
145. Schneider A., Kruger C., Steigleder T., et al. The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J Clin Invest 115 (2005) 2083-2098
146. Shen L.H., Li Y., Chen J., et al. Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke. J Cereb Blood Flow Metab 27 (2007) 6-13
147. Chen J., Li Y., Wang L., et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32 (2001) 1005-1011
148. Li Y., Chen J., Wang L., Lu M., and Chopp M. Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology 56 (2001) 1666-1672
149. Chen J., Li Y., Katakowski M., et al. Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat. J Neurosci Res 73 (2003) 778-786
150. Kagiwada H., Yashiki T., Ohshima A., Tadokoro M., Nagaya N., and Ohgushi H. Human mesenchymal stem cells as a stable source of VEGF-producing cells. J Tissue Eng Regen Med 2 (2008) 184-189
151. Payne T.R., Oshima H., Okada M., et al. A relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts. J Am Coll Cardiol 50 (2007) 1677-1684
152. Bang O.Y., Lee J.S., Lee P.H., and Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 57 (2005) 874-882
153. Borlongan C.V., Hadman M., Sanberg C.D., and Sanberg P.R. Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke. Stroke 35 (2004) 2385-2389
154. Vendrame M., Gemma C., Pennypacker K.R., et al. Cord blood rescues stroke-induced changes in splenocyte phenotype and function. Exp Neurol 199 (2006) 191-200
155. Makinen S., Kekarainen T., Nystedt J., et al. Human umbilical cord blood cells do not improve sensorimotor or cognitive outcome following transient middle cerebral artery occlusion in rats. Brain Res 1123 (2006) 207-215
156. Bjorklund L.M., Sanchez-Pernaute R., Chung S., et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A 99 (2002) 2344-2349
157. Ben-Hur T., Idelson M., Khaner H., et al. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells 22 (2004) 1246-1255
158. Takagi Y., Takahashi J., Saiki H., et al. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest 115 (2005) 102-109
159. Prokhorova T.A., Harkness L.M., Frandsen U., et al. Teratoma formation by human embryonic stem cells is site-dependent and enhanced by the presence of Matrigel. Stem Cells Dev 18 (2009) 47-54
160. Guo L., Yin F., Meng H.Q., et al. Differentiation of mesenchymal stem cells into dopaminergic neuron-like cells in vitro. Biomed Environ Sci 18 (2005) 36-42
161. Behrstock S., Ebert A., McHugh J., et al. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Ther 13 (2006) 379-388
162. Brazzini A., Cantell R., Gallardo A., et al. Intraarterial autologous implant of adult stem cell for patients with Parkinson's disease (abstr). J Vasc Interv Radiol 19 suppl 2 (2008) S111
163. Pluchino S., Zanotti L., Rossi B., et al. Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 436 (2005) 266-271
164. Casey J.J., Lakey J.R., Ryan E.A., et al. Portal venous pressure changes after sequential clinical islet transplantation. Transplantation 74 (2002) 913-915
165. Kania G., Blyszczuk P., Czyz J., Navarrete-Santos A., and Wobus A.M. Differentiation of mouse embryonic stem cells into pancreatic and hepatic cells. Methods Enzymol 365 (2003) 287-303
166. Kahan B.W., Jacobson L.M., Hullett D.A., et al. Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: an in vitro model to study islet differentiation. Diabetes 52 (2003) 2016-2024
167. Rajagopal J., Anderson W.J., Kume S., Martinez O.I., and Melton D.A. Insulin staining of ES cell progeny from insulin uptake. Science 299 (2003) 363
168. Ianus A., Holz G.G., Theise N.D., and Hussain M.A. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 111 (2003) 843-850
169. Hess D., Li L., Martin M., et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 21 (2003) 763-770
170. Jahr H., and Bretzel R.G. Insulin-positive cells in vitro generated from rat bone marrow stromal cells. Transplant Proc 35 (2003) 2140-2141
171. Oh S.H., Muzzonigro T.M., Bae S.H., LaPlante J.M., Hatch H.M., and Petersen B.E. Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes. Lab Invest 84 (2004) 607-617