메뉴 건너뛰기




Volumn 19, Issue 5, 2007, Pages 451-456

Cell-based cartilage repair: Illusion or solution for osteoarthritis

Author keywords

Autologous chondrocyte transplantation; Chondrogenesis; Hypertrophy; Marrow stimulation; Mesenchymal stem cell

Indexed keywords

BIOMATERIAL;

EID: 34548364094     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOR.0b013e3282a95e4c     Document Type: Review
Times cited : (49)

References (45)
  • 1
    • 0030972757 scopus 로고    scopus 로고
    • Current concepts in the treatment of articular cartilage defects
    • Minas T, Nehrer S. Current concepts in the treatment of articular cartilage defects. Orthopedics 1997; 20:525-538.
    • (1997) Orthopedics , vol.20 , pp. 525-538
    • Minas, T.1    Nehrer, S.2
  • 2
    • 0036083985 scopus 로고    scopus 로고
    • Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects
    • Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 2002; 10:432-463.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 432-463
    • Hunziker, E.B.1
  • 3
    • 33749343814 scopus 로고    scopus 로고
    • Results after microfracture of full-thickness chondral defects in different compartments in the knee
    • Kreuz PC, Steinwachs MR, Erggelet C, et al. Results after microfracture of full-thickness chondral defects in different compartments in the knee. Osteoarthritis Cartilage 2006; 14:1119-1125.
    • (2006) Osteoarthritis Cartilage , vol.14 , pp. 1119-1125
    • Kreuz, P.C.1    Steinwachs, M.R.2    Erggelet, C.3
  • 4
    • 0028031550 scopus 로고
    • Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
    • Brittberg M, Lindahl A, Nilsson A, et al. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994; 331:889-895.
    • (1994) N Engl J Med , vol.331 , pp. 889-895
    • Brittberg, M.1    Lindahl, A.2    Nilsson, A.3
  • 5
    • 0042635558 scopus 로고    scopus 로고
    • Articular cartilage engineering with autologous chondrocyte transplantation. A review of recent developments
    • Brittberg M, Peterson L, Sjogren-Jansson E, et al. Articular cartilage engineering with autologous chondrocyte transplantation. A review of recent developments. J Bone Joint Surg Am 2003; 85A (Suppl 3):109-115.
    • (2003) J Bone Joint Surg Am , vol.85 A , Issue.SUPPL. 3 , pp. 109-115
    • Brittberg, M.1    Peterson, L.2    Sjogren-Jansson, E.3
  • 6
    • 0032199210 scopus 로고    scopus 로고
    • Chondrocyte implantation in the repair of chondral lesions of the knee: Economics and quality of life
    • Minas T. Chondrocyte implantation in the repair of chondral lesions of the knee: economics and quality of life. Am J Orthop 1998; 27:739-744.
    • (1998) Am J Orthop , vol.27 , pp. 739-744
    • Minas, T.1
  • 8
    • 0034018392 scopus 로고    scopus 로고
    • Two- to 9-year outcome after autologous chondrocyte transplantation of the knee
    • Peterson L, Minas T, Brittberg M, et al. Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Rel Res 2000; 374:212-234.
    • (2000) Clin Orthop Rel Res , vol.374 , pp. 212-234
    • Peterson, L.1    Minas, T.2    Brittberg, M.3
  • 9
    • 7244220098 scopus 로고    scopus 로고
    • Indications and implementation of recommendations of the working group 'Tissue Regeneration and Tissue Substitutes' for autologous chondrocyte transplantation (ACT)
    • Behrens P, Bosch U, Bruns J, et al. Indications and implementation of recommendations of the working group 'Tissue Regeneration and Tissue Substitutes' for autologous chondrocyte transplantation (ACT). Z Orthop Ihre Grenzgeb 2004; 142:529-539.
    • (2004) Z Orthop Ihre Grenzgeb , vol.142 , pp. 529-539
    • Behrens, P.1    Bosch, U.2    Bruns, J.3
  • 11
    • 0037315539 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial
    • Horas U, Pelinkovic D, Herr G, et al. Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial. J Bone Joint Surg Am 2003; 85A:185-192.
    • (2003) J Bone Joint Surg Am , vol.85 A , pp. 185-192
    • Horas, U.1    Pelinkovic, D.2    Herr, G.3
  • 12
    • 10744225506 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial
    • Knutsen G, Engebretsen L, Ludvigsen TC, et al. Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am 2004; 86A:455-464.
    • (2004) J Bone Joint Surg Am , vol.86 A , pp. 455-464
    • Knutsen, G.1    Engebretsen, L.2    Ludvigsen, T.C.3
  • 13
    • 29844449078 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation: A systematic review
    • This overview on selected clinical cartilage repair studies addresses, beside outcome, also a possible conflict of interest of authors since many cartilage repair studies receive funding from companies
    • Ruano-Ravina A, Jato DM. Autologous chondrocyte implantation: a systematic review. Osteoarthritis Cartilage 2006; 14:47-51. This overview on selected clinical cartilage repair studies addresses, beside outcome, also a possible conflict of interest of authors since many cartilage repair studies receive funding from companies.
    • (2006) Osteoarthritis Cartilage , vol.14 , pp. 47-51
    • Ruano-Ravina, A.1    Jato, D.M.2
  • 14
    • 0037355664 scopus 로고    scopus 로고
    • A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee
    • Bentley G, Biant LC, Carrington RW, et al. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J Bone Joint Surg Br 2003; 85:223-230.
    • (2003) J Bone Joint Surg Br , vol.85 , pp. 223-230
    • Bentley, G.1    Biant, L.C.2    Carrington, R.W.3
  • 15
    • 33644920939 scopus 로고    scopus 로고
    • Autologous cultured chondrocytes: Adverse events reported to the United States Food and Drug Administration
    • An overview on the most common adverse events reported in association with the Carticel ACT technique of Genzyme reflecting graft failure, delamination and tissue hypertrophy as the most common adverse events
    • Wood JJ, Malek MA, Frassica FJ, et al. Autologous cultured chondrocytes: adverse events reported to the United States Food and Drug Administration. J Bone Joint Surg Am 2006; 88:503-507. An overview on the most common adverse events reported in association with the Carticel ACT technique of Genzyme reflecting graft failure, delamination and tissue hypertrophy as the most common adverse events.
    • (2006) J Bone Joint Surg Am , vol.88 , pp. 503-507
    • Wood, J.J.1    Malek, M.A.2    Frassica, F.J.3
  • 16
    • 0038077280 scopus 로고    scopus 로고
    • Histological assessment of cartilage repair: A report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS)
    • Mainil-Varlet P, Aigner T, Brittberg M, et al. Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am 2003; 85A (Suppl 2):45-57.
    • (2003) J Bone Joint Surg Am , vol.85 A , Issue.SUPPL. 2 , pp. 45-57
    • Mainil-Varlet, P.1    Aigner, T.2    Brittberg, M.3
  • 17
    • 0035148799 scopus 로고    scopus 로고
    • Matrix turnover in human cartilage repair tissue in autologous chondrocyte implantation
    • Roberts S, Hollander AP, Caterson B, et al. Matrix turnover in human cartilage repair tissue in autologous chondrocyte implantation. Arthritis Rheum 2001; 44:2586-2598.
    • (2001) Arthritis Rheum , vol.44 , pp. 2586-2598
    • Roberts, S.1    Hollander, A.P.2    Caterson, B.3
  • 18
    • 30444461215 scopus 로고    scopus 로고
    • Cartilage repair: Generations of autologous chondrocyte transplantation
    • Marlovits S, Zeller P, Singer P, et al. Cartilage repair: generations of autologous chondrocyte transplantation. Eur J Radiol 2006; 57:24-31.
    • (2006) Eur J Radiol , vol.57 , pp. 24-31
    • Marlovits, S.1    Zeller, P.2    Singer, P.3
  • 19
    • 0036326828 scopus 로고    scopus 로고
    • A cell-seeded biocomposite for cartilage repair
    • Russlies M, Behrens P, Wunsch L, et al. A cell-seeded biocomposite for cartilage repair. Ann Anat 2002; 184:317-323.
    • (2002) Ann Anat , vol.184 , pp. 317-323
    • Russlies, M.1    Behrens, P.2    Wunsch, L.3
  • 20
    • 0034918532 scopus 로고    scopus 로고
    • Transplantation of chondrocytes seeded on a hyaluronan derivative (hyaff-11) into cartilage defects in rabbits
    • Grigolo B, Roseti L, Fiorini M, et al. Transplantation of chondrocytes seeded on a hyaluronan derivative (hyaff-11) into cartilage defects in rabbits. Biomaterials 2001; 22:2417-2424.
    • (2001) Biomaterials , vol.22 , pp. 2417-2424
    • Grigolo, B.1    Roseti, L.2    Fiorini, M.3
  • 21
    • 18944373370 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: A prospective, randomised study
    • Bartlett W, Skinner JA, Gooding CR, et al. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study. J Bone Joint Surg Br 2005; 87:640-645.
    • (2005) J Bone Joint Surg Br , vol.87 , pp. 640-645
    • Bartlett, W.1    Skinner, J.A.2    Gooding, C.R.3
  • 22
    • 0142151440 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation for cartilage repair: Monitoring its success by magnetic resonance imaging and histology
    • Roberts S, McCall IW, Darby AJ, et al. Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology. Arthritis Res Ther 2003; 5:R60-R73.
    • (2003) Arthritis Res Ther , vol.5
    • Roberts, S.1    McCall, I.W.2    Darby, A.J.3
  • 23
    • 11844294603 scopus 로고    scopus 로고
    • Molecular and immunohistological characterization of human cartilage two years following autologous cell transplantation
    • Grigolo B, Roseti L, De Franceschi L, et al. Molecular and immunohistological characterization of human cartilage two years following autologous cell transplantation. J Bone Joint Surg Am 2005; 87:46-57.
    • (2005) J Bone Joint Surg Am , vol.87 , pp. 46-57
    • Grigolo, B.1    Roseti, L.2    De Franceschi, L.3
  • 24
    • 12344257714 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation in knee joint: MR imaging and histologic features at 1-year follow-up
    • Tins BJ, McCall IW, Takahashi T, et al. Autologous chondrocyte implantation in knee joint: MR imaging and histologic features at 1-year follow-up. Radiology 2005; 234:501-508.
    • (2005) Radiology , vol.234 , pp. 501-508
    • Tins, B.J.1    McCall, I.W.2    Takahashi, T.3
  • 25
    • 0036295210 scopus 로고    scopus 로고
    • Molecular analysis of expansion, differentiation, and growth factor treatment of human chondrocytes identifies differentiation markers and growth-related genes
    • Benz K, Breit S, Lukoschek M, et al. Molecular analysis of expansion, differentiation, and growth factor treatment of human chondrocytes identifies differentiation markers and growth-related genes. Biochem Biophys Res Commun 2002; 293:284-292.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 284-292
    • Benz, K.1    Breit, S.2    Lukoschek, M.3
  • 26
    • 0034945018 scopus 로고    scopus 로고
    • Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo
    • Dell'Accio F, De Bari C, Luyten FP. Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo. Arthritis Rheum 2001; 44:1608-1619.
    • (2001) Arthritis Rheum , vol.44 , pp. 1608-1619
    • Dell'Accio, F.1    De Bari, C.2    Luyten, F.P.3
  • 27
    • 20444429578 scopus 로고    scopus 로고
    • Adult mesenchymal stem cells: Characterization, differentiation, and application in cell and gene therapy
    • Baksh D, Song L, Tuan RS. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 2004; 8:301-316.
    • (2004) J Cell Mol Med , vol.8 , pp. 301-316
    • Baksh, D.1    Song, L.2    Tuan, R.S.3
  • 28
    • 0031817577 scopus 로고    scopus 로고
    • In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells
    • Johnstone B, Hering TM, Caplan AI, et al. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 1998; 238:265-272.
    • (1998) Exp Cell Res , vol.238 , pp. 265-272
    • Johnstone, B.1    Hering, T.M.2    Caplan, A.I.3
  • 29
    • 0037331189 scopus 로고    scopus 로고
    • Cartilage-like gene expression in differentiated human stem cell spheroids: A comparison of bone marrow-derived and adipose tissue-derived stromal cells
    • Winter A, Breit S, Parsch D, et al. Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells. Arthritis Rheum 2003; 48:418-429.
    • (2003) Arthritis Rheum , vol.48 , pp. 418-429
    • Winter, A.1    Breit, S.2    Parsch, D.3
  • 30
    • 23644456193 scopus 로고    scopus 로고
    • Comparison of human stem cells derived from various mesenchymal tissues: Superiority of synovium as a cell source
    • Sakaguchi Y, Sekiya I, Yagishita K, et al. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 2005; 52:2521-2529.
    • (2005) Arthritis Rheum , vol.52 , pp. 2521-2529
    • Sakaguchi, Y.1    Sekiya, I.2    Yagishita, K.3
  • 31
    • 34247587579 scopus 로고    scopus 로고
    • Hennig T, Lorenz H, Thiel A, et al. Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6. J Cell Physiol 2007; 211:682-691. A comprehensive analysis on expression of growth factors of the TGF-β superfamily and their receptors by human MSCs from bone marrow and adipose tissue, and the effect of 17 growth factors and combinations of growth factors on the success of in-vitro chondrogenesis.
    • Hennig T, Lorenz H, Thiel A, et al. Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6. J Cell Physiol 2007; 211:682-691. A comprehensive analysis on expression of growth factors of the TGF-β superfamily and their receptors by human MSCs from bone marrow and adipose tissue, and the effect of 17 growth factors and combinations of growth factors on the success of in-vitro chondrogenesis.
  • 32
    • 33646367147 scopus 로고    scopus 로고
    • Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6
    • Estes BT, Wu AW, Guilak F. Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arthritis Rheum 2006; 54:1222-1232.
    • (2006) Arthritis Rheum , vol.54 , pp. 1222-1232
    • Estes, B.T.1    Wu, A.W.2    Guilak, F.3
  • 33
    • 0036845282 scopus 로고    scopus 로고
    • Replicative aging of human articular chondrocytes during ex vivo expansion
    • Parsch D, Brummendorf TH, Richter W, et al. Replicative aging of human articular chondrocytes during ex vivo expansion. Arthritis Rheum 2002; 46:2911-2916.
    • (2002) Arthritis Rheum , vol.46 , pp. 2911-2916
    • Parsch, D.1    Brummendorf, T.H.2    Richter, W.3
  • 34
    • 0842330317 scopus 로고    scopus 로고
    • Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes
    • Parsch D, Fellenberg J, Brummendorf TH, et al. Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes. J Mol Med 2004; 82:49-55.
    • (2004) J Mol Med , vol.82 , pp. 49-55
    • Parsch, D.1    Fellenberg, J.2    Brummendorf, T.H.3
  • 35
    • 33750515870 scopus 로고    scopus 로고
    • Platelet-rich plasma improves expansion of human mesenchymal stem cells and retains differentiation capacity and in vivo bone formation in calcium phosphate ceramics
    • Vogel JP, Szalay K, Geiger F, et al. Platelet-rich plasma improves expansion of human mesenchymal stem cells and retains differentiation capacity and in vivo bone formation in calcium phosphate ceramics. Platelets 2006; 17:462-469.
    • (2006) Platelets , vol.17 , pp. 462-469
    • Vogel, J.P.1    Szalay, K.2    Geiger, F.3
  • 36
    • 0036184589 scopus 로고    scopus 로고
    • Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees
    • Wakitani S, Imoto K, Yamamoto T, et al. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage 2002; 10:199-206.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 199-206
    • Wakitani, S.1    Imoto, K.2    Yamamoto, T.3
  • 37
    • 0035882056 scopus 로고    scopus 로고
    • Chondrogenic differentiation of mesenchymal stem cells from bone marrow: Differentiation-dependent gene expression of matrix components
    • Barry F, Boynton RE, Liu B, et al. Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res 2001; 268:189-200.
    • (2001) Exp Cell Res , vol.268 , pp. 189-200
    • Barry, F.1    Boynton, R.E.2    Liu, B.3
  • 38
    • 15544381999 scopus 로고    scopus 로고
    • Induction of intervertebral disc-like cells from adult mesenchymal stem cells
    • Steck E, Bertram H, Abel R, et al. Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem Cells 2005; 23:403-411.
    • (2005) Stem Cells , vol.23 , pp. 403-411
    • Steck, E.1    Bertram, H.2    Abel, R.3
  • 39
    • 30544449685 scopus 로고    scopus 로고
    • Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture
    • Mauck RL, Yuan X, Tuan RS. Chondrogenic differentiation and functional maturation of bovine mesenchymal stem cells in long-term agarose culture. Osteoarthritis Cartilage 2006; 14:179-189.
    • (2006) Osteoarthritis Cartilage , vol.14 , pp. 179-189
    • Mauck, R.L.1    Yuan, X.2    Tuan, R.S.3
  • 40
    • 22544433139 scopus 로고    scopus 로고
    • Detailed examination of cartilage formation and endochondral ossification using human mesenchymal stem cells
    • Ichinose S, Yamagata K, Sekiya I, et al. Detailed examination of cartilage formation and endochondral ossification using human mesenchymal stem cells. Clin Exp Pharmacol Physiol 2005; 32:561-570.
    • (2005) Clin Exp Pharmacol Physiol , vol.32 , pp. 561-570
    • Ichinose, S.1    Yamagata, K.2    Sekiya, I.3
  • 41
    • 28944448291 scopus 로고    scopus 로고
    • The effect of glow discharge plasma surface modification of polymers on the osteogenic differentiation of committed human mesenchymal stem cells
    • Mwale F, Wang HT, Nelea V, et al. The effect of glow discharge plasma surface modification of polymers on the osteogenic differentiation of committed human mesenchymal stem cells. Biomaterials 2006; 27:2258-2264.
    • (2006) Biomaterials , vol.27 , pp. 2258-2264
    • Mwale, F.1    Wang, H.T.2    Nelea, V.3
  • 42
    • 33750321974 scopus 로고    scopus 로고
    • Pelttari K, Winter A, Steck E, et al. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 2006; 54:3254-3266. This study provides evidence that common protocols for in-vitro chondrogenesis of MSCs induce a differentiation program similar to endochondral bone formation and lead to transient cartilage rather than stable articular chondrocytes, which are resistant to hypertrophy in culture.
    • Pelttari K, Winter A, Steck E, et al. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 2006; 54:3254-3266. This study provides evidence that common protocols for in-vitro chondrogenesis of MSCs induce a differentiation program similar to endochondral bone formation and lead to transient cartilage rather than stable articular chondrocytes, which are resistant to hypertrophy in culture.
  • 43
    • 4644318980 scopus 로고    scopus 로고
    • Cyclic, mechanical compression enhances chondrogenesis of mesenchymal progenitor cells in tissue engineering scaffolds
    • Angele P, Schumann D, Angele M, et al. Cyclic, mechanical compression enhances chondrogenesis of mesenchymal progenitor cells in tissue engineering scaffolds. Biorheology 2004; 41:335-346.
    • (2004) Biorheology , vol.41 , pp. 335-346
    • Angele, P.1    Schumann, D.2    Angele, M.3
  • 44
    • 33745437125 scopus 로고    scopus 로고
    • Mechanobiological conditioning of stem cells for cartilage tissue engineering
    • Schumann D, Kujat R, Nerlich M, et al. Mechanobiological conditioning of stem cells for cartilage tissue engineering. Biomed Mater Eng 2006; 16:S37-S52.
    • (2006) Biomed Mater Eng , vol.16
    • Schumann, D.1    Kujat, R.2    Nerlich, M.3
  • 45
    • 33845412455 scopus 로고    scopus 로고
    • Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading
    • Mauck RL, Byers BA, Yuan X, et al. Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading. Biomech Model Mechanobiol 2007; 6:113-125.
    • (2007) Biomech Model Mechanobiol , vol.6 , pp. 113-125
    • Mauck, R.L.1    Byers, B.A.2    Yuan, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.