메뉴 건너뛰기




Volumn 2, Issue 4, 2007, Pages 417-423

Potential roles of bone marrow stem cells in stroke therapy

Author keywords

Acute stroke; Adult stem cells; Bone marrow; Neurological diseases; Neuroprotection; Stroke therapy; Trophic factors

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PLACEBO; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

EID: 34548181304     PISSN: 17460751     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460751.2.4.417     Document Type: Review
Times cited : (44)

References (48)
  • 1
    • 33846245504 scopus 로고    scopus 로고
    • Preventing stroke: Saving lives around the world
    • Strong K, Mathers C, Bonita R: Preventing stroke: saving lives around the world. Lancet Neurol. 6, 182-187 (2007).
    • (2007) Lancet Neurol , vol.6 , pp. 182-187
    • Strong, K.1    Mathers, C.2    Bonita, R.3
  • 2
    • 33750941791 scopus 로고    scopus 로고
    • Progressive decline in stroke mortality in Brazil from 1980 to 1982, 1990 to 1992, and 2000 to 2002
    • André C, Curioni CC, Braga da Cunha C, Veras R: Progressive decline in stroke mortality in Brazil from 1980 to 1982, 1990 to 1992, and 2000 to 2002. Stroke 37(11), 2784-2789 (2006).
    • (2006) Stroke , vol.37 , Issue.11 , pp. 2784-2789
    • André, C.1    Curioni, C.C.2    Braga da Cunha, C.3    Veras, R.4
  • 3
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke
    • The National Institute of Neurological Disorders and Stroke t-PA Stroke Study Group
    • The National Institute of Neurological Disorders and Stroke t-PA Stroke Study Group: Tissue plasminogen activator for acute ischemic stroke. N. Engl. J. Med. 333, 1581-1587 (1995).
    • (1995) N. Engl. J. Med , vol.333 , pp. 1581-1587
  • 4
    • 33846645451 scopus 로고    scopus 로고
    • Advances in emerging therapies
    • Lees KR, Dawson J: Advances in emerging therapies. Stroke 8, 219-221 (2007).
    • (2007) Stroke , vol.8 , pp. 219-221
    • Lees, K.R.1    Dawson, J.2
  • 5
    • 33750706917 scopus 로고    scopus 로고
    • Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
    • Roy NS, Cleren C, Singh SK, Yang L, Beel MF, Goldman SA: Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat. Med. 12(11), 1259-1268 (2006).
    • (2006) Nat. Med , vol.12 , Issue.11 , pp. 1259-1268
    • Roy, N.S.1    Cleren, C.2    Singh, S.K.3    Yang, L.4    Beel, M.F.5    Goldman, S.A.6
  • 6
    • 33645219877 scopus 로고    scopus 로고
    • Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons
    • Soundararajan P, Miles GB, Rubin LL, Brownstone RM, Rafuse VF: Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. J. Neurosci. 26(12), 3256-3268 (2006).
    • (2006) J. Neurosci , vol.26 , Issue.12 , pp. 3256-3268
    • Soundararajan, P.1    Miles, G.B.2    Rubin, L.L.3    Brownstone, R.M.4    Rafuse, V.F.5
  • 7
    • 2642550013 scopus 로고    scopus 로고
    • Functional integration of Embryonic stem cell-derived neurons in vivo
    • Wernig M, Benninger F, Schmandt T et al.: Functional integration of Embryonic stem cell-derived neurons in vivo. J. Neurosci. 24(22), 5258-5268 (2004).
    • (2004) J. Neurosci , vol.24 , Issue.22 , pp. 5258-5268
    • Wernig, M.1    Benninger, F.2    Schmandt, T.3
  • 8
    • 33845325474 scopus 로고    scopus 로고
    • Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats
    • Buhnemann C, Scholz A, Bemreuther C et al.: Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats. Brain 129(12), 3238-3248 (2006).
    • (2006) Brain , vol.129 , Issue.12 , pp. 3238-3248
    • Buhnemann, C.1    Scholz, A.2    Bemreuther, C.3
  • 9
    • 0035887595 scopus 로고    scopus 로고
    • Neuroprotection through delivery of glial cell line derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease
    • Akerud P, Canals JM, Snyder EY, Arenas E: Neuroprotection through delivery of glial cell line derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease. J. Neurosci. 21(20), 8108-8118 (2001).
    • (2001) J. Neurosci , vol.21 , Issue.20 , pp. 8108-8118
    • Akerud, P.1    Canals, J.M.2    Snyder, E.Y.3    Arenas, E.4
  • 10
    • 33645140627 scopus 로고    scopus 로고
    • Human neural progenitors deliver glial cell line derived neutrophic factor to parkinsonian rodents and aged primates
    • Behrstock S, Ebert A, McHugh J et al.: Human neural progenitors deliver glial cell line derived neutrophic factor to parkinsonian rodents and aged primates. Gene Ther. 13(5), 379-388 (2006).
    • (2006) Gene Ther , vol.13 , Issue.5 , pp. 379-388
    • Behrstock, S.1    Ebert, A.2    McHugh, J.3
  • 11
    • 18444381777 scopus 로고    scopus 로고
    • GDNF delivery using human neural progenitor cells in a rat model of ALS
    • Klein SM, Behrstock S, McHugh J et al.: GDNF delivery using human neural progenitor cells in a rat model of ALS. Hum. Gene Ther. 16(4), 509-521 (2005).
    • (2005) Hum. Gene Ther , vol.16 , Issue.4 , pp. 509-521
    • Klein, S.M.1    Behrstock, S.2    McHugh, J.3
  • 12
    • 0035826089 scopus 로고    scopus 로고
    • Transplantation of embryonic dopamine neurons for severe Parkinson's disease
    • Freed CR, Greene PE, Breeze RE et al.: Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 344, 710-719 (2001).
    • (2001) N. Engl. J. Med , vol.344 , pp. 710-719
    • Freed, C.R.1    Greene, P.E.2    Breeze, R.E.3
  • 13
    • 0042131826 scopus 로고    scopus 로고
    • Adult stem cells for tissue repair - a new therapeutic concept?
    • Korbling M, Estrov Z: Adult stem cells for tissue repair - a new therapeutic concept? N. Engl. J. Med. 349, 570-582 (2003).
    • (2003) N. Engl. J. Med , vol.349 , pp. 570-582
    • Korbling, M.1    Estrov, Z.2
  • 14
    • 33745437684 scopus 로고    scopus 로고
    • Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue
    • Kern S, Eichler H, Stoeve J, Kluter H, Bieback K: Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24, 1294-1301 (2006).
    • (2006) Stem Cells , vol.24 , pp. 1294-1301
    • Kern, S.1    Eichler, H.2    Stoeve, J.3    Kluter, H.4    Bieback, K.5
  • 15
    • 34249714157 scopus 로고    scopus 로고
    • Mezey E: Bone marrow-derived stem cells in neurological diseases stones or masons? Regen. Med. 2(1), 37-49 (2007).
    • Mezey E: Bone marrow-derived stem cells in neurological diseases stones or masons? Regen. Med. 2(1), 37-49 (2007).
  • 16
    • 33846705350 scopus 로고    scopus 로고
    • Cell transplantation therapy for stroke
    • Bliss T, Guzman R, Daadi M, Steinberg GF: Cell transplantation therapy for stroke. Stroke 38(2), 817-826 (2007).
    • (2007) Stroke , vol.38 , Issue.2 , pp. 817-826
    • Bliss, T.1    Guzman, R.2    Daadi, M.3    Steinberg, G.F.4
  • 17
    • 34250747913 scopus 로고    scopus 로고
    • Migration, fate and in vivo imaging of adult stem cells in the CNS
    • Sykova E, Jandelova P: Migration, fate and in vivo imaging of adult stem cells in the CNS. Cell Death Differ. 14, 1336-1342 (2007).
    • (2007) Cell Death Differ , vol.14 , pp. 1336-1342
    • Sykova, E.1    Jandelova, P.2
  • 18
    • 20844453744 scopus 로고    scopus 로고
    • Transplantation of umbilical-cord blood in babies with infantile Krabbeis disease
    • Escolar ML, Poe MD, Provenzale JM et al.: Transplantation of umbilical-cord blood in babies with infantile Krabbeis disease. N. Engl. J. Med. 352(20), 2069-2081 (2005).
    • (2005) N. Engl. J. Med , vol.352 , Issue.20 , pp. 2069-2081
    • Escolar, M.L.1    Poe, M.D.2    Provenzale, J.M.3
  • 19
    • 33846240478 scopus 로고    scopus 로고
    • Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury
    • Sykova E, Homola A, Mazanec R et al.: Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury. Cell Transplant. 15(8-9), 675-687 (2006).
    • (2006) Cell Transplant , vol.15 , Issue.8-9 , pp. 675-687
    • Sykova, E.1    Homola, A.2    Mazanec, R.3
  • 20
    • 0038701741 scopus 로고    scopus 로고
    • Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure
    • Perin EC, Dohmann HFR, Borojevic R et al.: Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 107, 2294-2302 (2003).
    • (2003) Circulation , vol.107 , pp. 2294-2302
    • Perin, E.C.1    Dohmann, H.F.R.2    Borojevic, R.3
  • 21
    • 3042710733 scopus 로고    scopus 로고
    • Intracoronary autologous bone-marrow cell transfer after myocardial infarction: The BOOST randomised controlled clinical trial
    • Wollert KC Meyer GP, Lotz J et al.: Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 364, 141-148 (2004).
    • (2004) Lancet , vol.364 , pp. 141-148
    • Wollert, K.C.1    Meyer, G.P.2    Lotz, J.3
  • 22
    • 34249677836 scopus 로고    scopus 로고
    • Bone marrow-derived stem cell therapy in ischemic heart disease
    • Cho H-J, Lee J, Wecker A, Yoon Y: Bone marrow-derived stem cell therapy in ischemic heart disease. Regen. Med. 1(3), 337-345 (2006).
    • (2006) Regen. Med , vol.1 , Issue.3 , pp. 337-345
    • Cho, H.-J.1    Lee, J.2    Wecker, A.3    Yoon, Y.4
  • 23
    • 34249739638 scopus 로고    scopus 로고
    • Realizing the cardiac stem cell promise: A case for trophism
    • Pallante BA, Edelberg JM: Realizing the cardiac stem cell promise: a case for trophism. Regen. Med. 1(2), 217-221 (2006).
    • (2006) Regen. Med , vol.1 , Issue.2 , pp. 217-221
    • Pallante, B.A.1    Edelberg, J.M.2
  • 24
    • 0033845975 scopus 로고    scopus 로고
    • Transplantation of cultured human neuronal cells for patients with stroke
    • Kondziolka D, Wechsler L, Goldstein S et al.: Transplantation of cultured human neuronal cells for patients with stroke. Neurology 55, 565-569 (2000).
    • (2000) Neurology , vol.55 , pp. 565-569
    • Kondziolka, D.1    Wechsler, L.2    Goldstein, S.3
  • 25
    • 24944466539 scopus 로고    scopus 로고
    • Neurotransplantation for patients with subcortical motor stroke a Phase 2 ramdomized trial
    • Kondziolka D, Steinberg GK, Wechsler L et al.: Neurotransplantation for patients with subcortical motor stroke a Phase 2 ramdomized trial. J. Neurosurg. 103(1), 38-45 (2005).
    • (2005) J. Neurosurg , vol.103 , Issue.1 , pp. 38-45
    • Kondziolka, D.1    Steinberg, G.K.2    Wechsler, L.3
  • 26
    • 0034882924 scopus 로고    scopus 로고
    • Serial [18F] fluorodeoxyglucose positron emission tomography after human neuronal implantation for stroke
    • Meltzer CC, Kondziolka D, Villemagne VL et al.: Serial [18F] fluorodeoxyglucose positron emission tomography after human neuronal implantation for stroke. Neurosurgery 49(3), 586-591 (2001).
    • (2001) Neurosurgery , vol.49 , Issue.3 , pp. 586-591
    • Meltzer, C.C.1    Kondziolka, D.2    Villemagne, V.L.3
  • 27
    • 0036114274 scopus 로고    scopus 로고
    • Clonal human (hNT) neuron grafts for stroke therapy: Neuropathology in a patient 27 months after implantation
    • Nelson PT, Kondziolka D, Wechsler L et al.: Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation. Am. J. Pathol. 160, 1201-1206 (2002).
    • (2002) Am. J. Pathol , vol.160 , pp. 1201-1206
    • Nelson, P.T.1    Kondziolka, D.2    Wechsler, L.3
  • 28
    • 23844487540 scopus 로고    scopus 로고
    • Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts a preliminary safety and feasibility study
    • Savitz SI, Dinsmore J, Wu J et al.: Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts a preliminary safety and feasibility study. Cerebrovasc. Dis 20, 101-107 (2005).
    • (2005) Cerebrovasc. Dis , vol.20 , pp. 101-107
    • Savitz, S.I.1    Dinsmore, J.2    Wu, J.3
  • 29
    • 24644446859 scopus 로고    scopus 로고
    • G-CSF suppresses edema formation and reduces interleukin-1β expression after cerebral ischemia in mice
    • Gibson CL, Jones NC, Prior MJ et al.: G-CSF suppresses edema formation and reduces interleukin-1β expression after cerebral ischemia in mice. J. Neuropathol. Exp. Neurol. 64(9), 763-769 (2005).
    • (2005) J. Neuropathol. Exp. Neurol , vol.64 , Issue.9 , pp. 763-769
    • Gibson, C.L.1    Jones, N.C.2    Prior, M.J.3
  • 30
    • 33645838140 scopus 로고    scopus 로고
    • A novel neuroprotectant granulocyte-colony stimulating factor
    • Solaroglu I, Cahill J, Jedhav V et al.: A novel neuroprotectant granulocyte-colony stimulating factor. Stroke 37, 1123-1128 (2006).
    • (2006) Stroke , vol.37 , pp. 1123-1128
    • Solaroglu, I.1    Cahill, J.2    Jedhav, V.3
  • 31
    • 23644445498 scopus 로고    scopus 로고
    • The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    • Schneider A, Kruger C, Steigleder T et al.: The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis. J. Clin. Invest. 115, 2083-2098 (2005).
    • (2005) J. Clin. Invest , vol.115 , pp. 2083-2098
    • Schneider, A.1    Kruger, C.2    Steigleder, T.3
  • 32
    • 37549052559 scopus 로고    scopus 로고
    • Schabitz WR, Kruger C, Pitzer C et al.: A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF). J. Cereb. Blood Flow Metab. DOI 10.1038/ sj.jcbfm.9600496 (2007) (Epub ahead of print).
    • Schabitz WR, Kruger C, Pitzer C et al.: A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF). J. Cereb. Blood Flow Metab. DOI 10.1038/ sj.jcbfm.9600496 (2007) (Epub ahead of print).
  • 34
    • 29244440582 scopus 로고    scopus 로고
    • Treatment with AX 200 (granulocyte-colony stimulating factor) for acute ischemic stroke (AXIS)
    • New Orleans, LA, USA
    • Schabitz WR, Schneider A, Kollmar R et al.: Treatment with AX 200 (granulocyte-colony stimulating factor) for acute ischemic stroke (AXIS). International Stroke Conference, New Orleans, LA, USA (2005).
    • (2005) International Stroke Conference
    • Schabitz, W.R.1    Schneider, A.2    Kollmar, R.3
  • 35
    • 33645567790 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor for acute ischemic stroke a randomized controlled trial
    • Shyu WC, Lin SZ, Lee CC et al.: Granulocyte colony-stimulating factor for acute ischemic stroke a randomized controlled trial. CMAJ 174, 927-933 (2006).
    • (2006) CMAJ , vol.174 , pp. 927-933
    • Shyu, W.C.1    Lin, S.Z.2    Lee, C.C.3
  • 36
    • 33845480805 scopus 로고    scopus 로고
    • Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke. The Stem Cell Trial of Recovery EnhanceMent After Stroke (ST EM S) pilot randomized, controlled trial (ISRCTN 16784092)
    • Sprigg N, Bath PM, Zhao L et al.: Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke. The Stem Cell Trial of Recovery EnhanceMent After Stroke (ST EM S) pilot randomized, controlled trial (ISRCTN 16784092). Stroke 37(12), 2979-2983 (2006).
    • (2006) Stroke , vol.37 , Issue.12 , pp. 2979-2983
    • Sprigg, N.1    Bath, P.M.2    Zhao, L.3
  • 37
    • 33947605748 scopus 로고    scopus 로고
    • New targets for established proteins exploring G-CSF for treatment of stroke
    • Schabitz W-R, Schneider A: New targets for established proteins exploring G-CSF for treatment of stroke. Trends Pharmacol. Sci. 28, 157-161 (2007).
    • (2007) Trends Pharmacol. Sci , vol.28 , pp. 157-161
    • Schabitz, W.-R.1    Schneider, A.2
  • 38
    • 20444419744 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation in stroke patients
    • Bang OY, Lee JS, Lee PH et al.: Autologous mesenchymal stem cell transplantation in stroke patients. Ann. Neurol. 57(6), 874-882 (2005).
    • (2005) Ann. Neurol , vol.57 , Issue.6 , pp. 874-882
    • Bang, O.Y.1    Lee, J.S.2    Lee, P.H.3
  • 39
    • 33344477474 scopus 로고    scopus 로고
    • Safety of intra-arterial autologous bone marrow mononuclear cell transplantation for acute ischemic stroke
    • Mendonca ML, Freitas GR, Silva SA et al.: Safety of intra-arterial autologous bone marrow mononuclear cell transplantation for acute ischemic stroke. Arq. Bras Cardiol. 86(1), 52-55 (2006).
    • (2006) Arq. Bras Cardiol , vol.86 , Issue.1 , pp. 52-55
    • Mendonca, M.L.1    Freitas, G.R.2    Silva, S.A.3
  • 40
    • 23944475670 scopus 로고    scopus 로고
    • Dual-head coincidence gamma camera FD G-PET before and after autologous bone marrow mononuclear cell implantation in ischaemic stroke
    • Correa P, Felix R, Mendonca ML et al.: Dual-head coincidence gamma camera FD G-PET before and after autologous bone marrow mononuclear cell implantation in ischaemic stroke. Eur. J. Nucl. Med. Mol. Imaging 32, 999 (2005).
    • (2005) Eur. J. Nucl. Med. Mol. Imaging , vol.32 , pp. 999
    • Correa, P.1    Felix, R.2    Mendonca, M.L.3
  • 41
    • 34548185761 scopus 로고    scopus 로고
    • Assessment of bone marrow mononuclear cells distribution by radioactive labeling after stem cell therapy in acute ischemic stroke
    • Correa P, Mesquita CT, Felix R et al.: Assessment of bone marrow mononuclear cells distribution by radioactive labeling after stem cell therapy in acute ischemic stroke. Abstracts from the International Stroke Conference. Stroke 37, 647 (2006).
    • (2006) Abstracts from the International Stroke Conference. Stroke , vol.37 , pp. 647
    • Correa, P.1    Mesquita, C.T.2    Felix, R.3
  • 42
    • 66149151542 scopus 로고    scopus 로고
    • Safety and feasibility of intra-arterial autologous bone marrow mononuclear cell transplantation in acute ischemic stroke
    • de Freitas GR, Mendonça MLF, Bezerra DC et al.: Safety and feasibility of intra-arterial autologous bone marrow mononuclear cell transplantation in acute ischemic stroke. Abstracts from the International Stroke Conference Stroke 37, 624-625 (2006).
    • (2006) Abstracts from the International Stroke Conference Stroke , vol.37 , pp. 624-625
    • de Freitas, G.R.1    Mendonça, M.L.F.2    Bezerra, D.C.3
  • 44
    • 33749334622 scopus 로고    scopus 로고
    • Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF-I in response to TNF by a p38 MAPK-dependent mechanism
    • Wang M, Crisostomo PR, Herring C et al.: Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF, and IGF-I in response to TNF by a p38 MAPK-dependent mechanism. Am. J Physiol. Regul. Integr. Comp. Physiol. 291(4), 880-884 (2006).
    • (2006) Am. J Physiol. Regul. Integr. Comp. Physiol , vol.291 , Issue.4 , pp. 880-884
    • Wang, M.1    Crisostomo, P.R.2    Herring, C.3
  • 45
    • 33344460695 scopus 로고    scopus 로고
    • VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
    • Le Bras B, Barallobre MJ, Homman-Ludiye J et al.: VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nat. Neurosci. 9(3), 340-348 (2006).
    • (2006) Nat. Neurosci , vol.9 , Issue.3 , pp. 340-348
    • Le Bras, B.1    Barallobre, M.J.2    Homman-Ludiye, J.3
  • 46
    • 33747605320 scopus 로고    scopus 로고
    • Molecular biology of amyotrophic lateral sclerosis insights from genetics
    • Pasinelli P, Brown RH: Molecular biology of amyotrophic lateral sclerosis insights from genetics. Nat. Rev. Neurosci. 7(9), 710-723 (2006).
    • (2006) Nat. Rev. Neurosci , vol.7 , Issue.9 , pp. 710-723
    • Pasinelli, P.1    Brown, R.H.2
  • 47
    • 16644382257 scopus 로고    scopus 로고
    • Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
    • Storkebaum E, Lambrechts D, Dewerchin M et al.: Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat. Neurosci. 8(1), 85-92 (2005).
    • (2005) Nat. Neurosci , vol.8 , Issue.1 , pp. 85-92
    • Storkebaum, E.1    Lambrechts, D.2    Dewerchin, M.3
  • 48
    • 33845242529 scopus 로고    scopus 로고
    • Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways
    • Kilic U, Kilic E, Jarve A et al.: Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J. Neurosci. 26, 12439-12446 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 12439-12446
    • Kilic, U.1    Kilic, E.2    Jarve, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.