Magnetic Resonance Tracking of Transplanted Bone Marrow and Embryonic Stem Cells Labeled by Iron Oxide Nanoparticles in Rat Brain and Spinal Cord

Journal of Neuroscience Research

Volumn 76, Issue 2, 2004, Pages 232-243

  Jendelová, Pavla ^a,b   Herynek, Vít ^c   Urdzíková, Lucia ^b   Glogarová, Kateřina ^a,b   Kroupová, Jana ^b,d   Andersson, Benita ^b,e   Bryja, Vítězslav ^a,b   Burian, Martin ^c   Hájek, Milan ^c   Syková, Eva ^a,b  

^a INSTITUTE OF EXPERIMENTAL BOTANY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^d MENDEL UNIVERSITY IN BRNO   (Czech Republic)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cell transplantation; Contrast agents; Injury; Magnetic resonance; Photochemical lesion; Spinal cord lesion

Indexed keywords

BROXURIDINE; FERRIC FERROCYANIDE; GREEN FLUORESCENT PROTEIN; IRON OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ASTROCYTE; BRAIN INJURY; CELL DIFFERENTIATION; CELL MIGRATION; CELL TRANSPLANTATION; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS CALLOSUM; ELECTRON MICROSCOPY; EMBRYONIC STEM CELL; HEMATOPOIETIC STEM CELL; HEMISPHERE; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOTOPE LABELING; NERVE CELL; NON INVASIVE MEASUREMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; SPINAL CORD COMPRESSION; STAINING; STEM CELL TRANSPLANTATION; STROMA CELL;

ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; BRAIN; BRAIN INJURIES; CELLS, CULTURED; EMBRYO; FERRIC COMPOUNDS; GLIAL FIBRILLARY ACIDIC PROTEIN; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; LUMINESCENT PROTEINS; MAGNETIC RESONANCE IMAGING; MICE; MICROSCOPY, ELECTRON; NEUROGLIA; NEURONS; PHOSPHOPYRUVATE HYDRATASE; RATS; RATS, WISTAR; SPINAL CORD; SPINAL CORD COMPRESSION; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 11144354992     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20041     Document Type: Conference Paper

References (40)

1. Bjorklund A, Dunnett SB, Brundin P, Stoessl AJ, Freed CR, Breeze RE, Levivier M, Peschanski M, Studer L, Barker R. 2003. Neural transplantation for the treatment of Parkinson's disease. Lancet Neurol 2:437-445.
2. Bjorklund LM, Sanchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O. 2002. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci USA 99:2344-2349.
3. Brustle O, Jones KN, Learish RD, Karram K, Choudhary K, Wiestler OD, Duncan ID, McKay RD. 1999. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science 285:754-756.
4. Bulte JW, Bryant LHJ. 2001. Molecular and cellular magnetic resonance contrast agents. In: De Cuyper M, Bulte JW, editors. Physics and chemistry basis of biotechnology. Dordrecht, The Netherlands: Kluwer Academic Publishers. p 197-211.
5. Bulte JW, Brooks RA, Moskowitz BM, Bryant LHJ, Frank JA. 1999a. Relaxometry and magnetometry of the MR contrast agent MION-46L. Magn Reson Med 42:379-384.
6. Bulte JW, Zhang SC, van Gelderen P, Herynek V, Jordan EK, Duncan ID, Frank JA. 1999b. Neurotransplantation of magnetically labeled oligodendrocyte progenitors: magnetic resonance tracking of cell migration and myelination. Proc Natl Acad Sci USA 96:15256-15261.
7. Bulte JW, Douglas T, Witwer B, Zhang SC, Strable E, Lewis BK, Zywicke H, Miller B, van Gelderen P, Moskowitz BM, Duncan ID, Frank JA. 2001. Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 19:1141-1147.
8. Chen X, Katakowski M, Li Y, Lu D, Wang L, Zhang L, Chen J, Xu Y, Gautam S, Mahmood A, Chopp M. 2002. Human bone marrow stromal cells cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res 69:687-691.
9. de Laquintane BD, Dousset V, Solanilla A, Petry KG, Ripoche J. 2002. Iron particle labeling of haematopoietic progenitor cells: an in vitro study. Biosci Rep 22:549-554.
10. Doetschman TC, Eistetter H, Katz M, Schmidt W, Kelmer R. 1985. The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol 87:27-45.
11. Eaves CJ, Cashman JD, Kay RJ, Dougherty GJ, Otsuka T, Gaboury LA, Hogge DE, Lansdorp PM, Eaves AC, Humphries RK. 1991. Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer. Blood 78:110-117.
12. Frank JA, Miller BR, Arbab AS, Zywicke HA, Jordan EK, Lewis BK, Bryant LH, Jr., Bulte JW. 2003. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 228:480-487.
13. Franklin RJ, Blaschuk KL, Bearchell MC, Prestoz LL, Setzu A, Brindle KM, ffrench-Constant C. 1999. Magnetic resonance imaging of transplanted oligodendrocyte precursors in the rat brain. Neuroreport 10:3961-3965.
14. Gage FH. 2002. Neurogenesis in the adult brain. J Neurosci 22:612-613.
15. Hawrylak N, Ghosh P, Broadus J, Schlueter C, Greenough WT, Lauterbur PC. 1993. Nuclear magnetic resonance (NMR) imaging of iron oxide-labeled neural transplants. Exp Neurol 121:81-92.
16. Hoehn M, Kustermann E, Blunk J, Wiedermann D, Trapp T, Focking M, Arnold H, Hescheler J, Fleischmann BK, Buhrle C. 2002. Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimantal stroke in rat. Proc Natl Acad Sci USA 100:1073-1078.
17. Hofstetter CP, Schwarz EJ, Hess D, Widenfalk J, El Manira A, Prockop JD, Olson L. 2002. Marrow stromal cellsform guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci USA 96:2199-2204.
18. Isacson O. 2003. The production and use of cells as therapeutic agents in neurodegenerative diseases. Lancet Neurol 2:417-424.
19. Jendelová P, Herynek V, De Croos J, Glogarová K, Andersson B, Hájek M, Syková E. 2003. Imaging the fate of implanted bone marrow stromal cells labeled with superparamagnetic nanoparticles. Magn Reson Med 50:767-776.
20. Kopen GC, Prockop DJ, Phinney DG. 1999. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 96:10711-10716.
21. Li Y, Chopp M, Chen J, Wang L, Gautam SC, Xu YX, Zhang Z. 2000. Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J Cereb Blood Flow Metab 20:1311-1319.
22. Li Y, Chen J, Chen J, Wang L, Lu M, Chopp M. 2001. Treatment of stroke in rat with itracarotid administration of marrow stromal cells. Neurology 56:1666-1672.
23. Lu D, Mahmood A, Wang L, Li Y, Lu M, Chopp M. 2001. Adult bone marrow stromal cells administered intravenously to rats after traumatic brain injury migrate into brain and improve neurological outcome. Neuroreport 12:559-563.
24. Maysinger D, Berezovskaya O, Fedoroff S. 1996. The hematopoietic cytokine colony stimulating factor 1 is also a growth factor in the CNS: (II). Microencapsulated CSF-1 and LM-10 cells as delivery systems. Exp Neurol 141:47-56.
25. McDonald JW, Liu XZ, Qu Y, Liu S, Mickey SK, Turetsky D, Gottlieb DI, Choi DW. 1999. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 5:1410-1412.
26. Norman AB, Thomas SR, Pratt RG, Lu SY, Norgren RB. 1992. Magnetic resonance imaging of neural transplants in rat brain using a superparamagnetic contrast agent. Brain Res 594:279-283.
27. Pachernik J, Esner M, Bryja V, Dvorak P, Hampl A. 2002. Neural differentiation of mouse embryonic stem cells grown in monolayer. Reprod Nutr Dev 42:317-326.
28. Paxinos G, Watson C. 1986. The rat brain in stereotaxic coordinates. Sydney: Academic Press.
29. Shamblott MJ, Axelman J, Wang S, Bugg EM, Littlefield JW, Donovan PJ, Blumenthal PD, Huggins GR, Gearhart JD. 1998. Denvation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci USA 95:13726-13731.
30. Silani V, Leigh N. 2003. Stem therapy for ALS: hope and reality. Amyotroph Lateral Scler Other Motor Neuron Disord 4:8-10.
31. Sipe JC, Filippi M, Martino G, Furlan R, Rocca MA, Rovaris M, Bergami A, Zyroff J, Scotti G, Comi G. 1999. Method for intracellular magnetic labeling of human mononuclear cells using approved iron contrast agents. Magn Reson Imaging 17:1521-1523.
32. Taupin P, Gage FH. 2002. Adult neurogenesis and neural stem cells of the central nervous system in mammals. J Neurosci Res 69:745-749.
33. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. 1998. Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147.
34. van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH. 2002. Functional neurogenesis in the adult hippocampus. Nature 415:1030-1034.
35. Vanicky I, Urdzikova L, Saganova K, Cizkova D, Galik J. 2001. A simple and reproducible model of spinal cord injury induced by epidural balloon inflation in the rat. J Neurotrauma 18:1399-1407.
36. Wang YX, Hussain SM, Krestin GP. 2001. Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur Radiol 11:2319-2331.
37. Watson BD, Dietrich WD, Busto R, Wachtel MS, Ginsberg MD. 1985. Induction of reproducible brain infarction by photochemically initiated thrombosis. Ann Neurol 17:497-504.
38. Weissleder R, Cheng HC, Bogdanova A, Bogdanov A Jr. 1997. Magnetically labeled cells can be detected by MR imaging. J Magn Reson Imaging 7:258-263.
39. Yeh T, Zhang W, Ildstad ST, Ho C. 1993. Intracellular labeling of T-cells with superparamagnetic contrast agents. Magn Reson Med 30:617-625.
40. Yeh T, Zhang W, Ildstad ST, Ho C. 1995. In vivo dynamic MRI tracking of rat T-cells labeled with superparamagnetic iron oxide particles. Magn Reson Med 33:200-208.