Adult bone marrow-derived cells trans differentiating into insulin-producing cells for the treatment of type I diabetes

Laboratory Investigation

Volumn 84, Issue 5, 2004, Pages 607-617

  Oh, Seh Hoon ^a   Muzzonigro, Toni M ^a   Bae, Si Hyun ^a   LaPlante, Jennifer M ^a   Hatch, Heather M ^a   Petersen, Bryon E ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Bone marrow cell; C peptide; Diabetic therapy; Insulin; Trans differentiation

Indexed keywords

C PEPTIDE; GLUCAGON; GLUCOSE TRANSPORTER 2; INSULIN; PANCREAS POLYPEPTIDE; PROINSULIN; SOMATOSTATIN; MESSENGER RNA; PANCREAS HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOCYTOCHEMISTRY; IMMUNOGOLD ELECTRON MICROSCOPY; IN SITU HYBRIDIZATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SYNTHESIS; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BONE MARROW TRANSPLANTATION; CELL CULTURE; GENE EXPRESSION; GENETICS; METABOLISM; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; PATHOLOGY; PHYSIOLOGY; RAT; XENOGRAFT;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; GENE EXPRESSION; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED NOD; MICE, SCID; MICROSCOPY, ELECTRON; PANCREATIC HORMONES; RATS; RNA, MESSENGER; TRANSPLANTATION, HETEROLOGOUS;

EID: 2942594624     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700074     Document Type: Article

References (37)

1. Weissman IL. Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Science 2000;287:1442-1446.
2. Steindler DA, Pincus DW. Stem cells and neuropoiesis in the adult human brain. Lancet 2002;359:1047-1054.
3. Scott EW, Simon MC, Anastasi J, et al. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 1994;265:1573-1577.
4. Petersen BE, Zajac VF, Michalopoulos GK. Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats. Hepatology 1998;27:1030-1038.
5. Petersen BE, Bowen WC, Patrene KD, et al. Bone marrow as a potential source of hepatic oval cells. Science 1999;284:1168-1170.
6. Theise ND, Badve S, Saxena R, et al. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 2000;31:235-240.
7. Oh SH, Miyazaki M, Kouchi H, et al. Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro. Biochem Biophys Res Commun 2000;279:500-504.
8. Hellerstrom C. The life story of the pancreatic β-cell. Diabetologia 1984;26:393-400.
9. Rosenberg L, Vinik AI. Trophic stimulation of the ductular-islet cell axis: a new approach to the treatment of diabetes. Adv Exp Med Biol 1992;321:95-104.
10. Swenne I. Pancreatic beta-cell growth and diabetes mellitus. Diabetologia 1992;35:193-201.
11. Guz Y, Nasir I, Teitelman G, Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology 2001;142:4956-4968.
12. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230-238.
13. Bonner-Weir S, Taneja M, Weir GC, et al. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 2000;97:7999-8004.
14. Halvorsen T, Levine F. Diabetes mellitus-cell transplantation and gene therapy approaches. Curr Mol Med 2001;1:273-286.
15. Ramiya VK, Maraist M, Arfors KE, et al. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med 2000;63:278-282.
16. Yang L, Li S, Hatch H, et al. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci USA 2002;99:8078-8083.
17. Lumelsky N, Blondel O, Laeng P, et al. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001;292:1389-1394.
18. Soria B, Roche E, Berna G, et al. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000;49:157-162.
19. Michalopoulos G, Pitot HC. Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations. Exp Cell Res 1975;94:70-78.
20. Orci L, Thorens B, Ravazzola M, et al. Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains. Science 1989;245:295-297.
21. Bendayan M. Ultrastructural localization of insulin and C-peptide antigenic sites in rat pancreatic B cell obtained by applying the quantitative high-resolution protein A-gold approach. Am J Anat 1997;185:205-216.
22. Fernandes A, King LC, Guz Y, et al. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 1997;138:1750-1762.
23. Kodama S, Kuhtreiber W, Fujimura S, et al. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 2003;302:1223-1227.
24. Rickard DJ, Sullivan TA, Shenker BJ, et al. Induction of rapid osteoblast differentiation in rat bone marrow stromal cell cultures by dexamethasone and BMP-2. Dev Biol 1994;161:218-228.
25. Ferrari G, Cusella-De Angelis G, Coletta M, et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 1998;279:1528-1530.
26. Umezawa A, Maruyama T, Segawa K, et al. Multipotent marrow stromal cell line is able to induce hematopoiesis in vivo. J Cell Physiol 1992;151:197-205.
27. Ashton BA, Allen TD, Howlett CR, et al. Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo. Clin Orthop 1980;151:294-307.
28. Makino S, Fukuda K, Miyoshi S, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999;103:697-705.
29. Kopen GC, Prockop DJ, Phinney DG. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci USA 1999;96:10711-10716.
30. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41-49.
31. Reyes M, Dudek A, Jahagirdar B, et al. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest 2002;109:337-346.
32. Rajagopol J, Anderson WJ, Kume S, et al. Insulin staining of ES cell progeny from insulin uptake. Science 2003;299:363.
33. Terada N, Hamazaki T, Oka M, et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002;416:542-545.
34. Ying QL, Nichols J, Evans EP, et al. Changing potency by spontaneous fusion. Nature 2002;416:545-548.
35. Wang X, Willenbring H, Akkari Y, et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003;422:897-901.
36. Vassilopoulos G, Wang PR, Russell DW. Transplanted bone marrow regenerates liver by cell fusion. Nature 2003;422:901-904.
37. Ianus A, Holz GG, Theise ND, et al. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003;111:843-850.