6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA

Journal of Neurochemistry

Volumn 104, Issue 6, 2008, Pages 1599-1612

  Gomez Lazaro, Maria ^a   Galindo, Maria F ^a   Concannon, Caoimhín G ^b   Segura, Miguel F ^c   Fernandez Gomez, Francisco J ^a   Llecha, Nuria ^d   Comella, Joan X ^c   Prehn, Jochen H M ^b   Jordan, Joaquin ^a,e  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c UNIVERSITY OF LLEIDA   (Spain)

^d HOSPITAL UNIVERSITARI ARNAU DE VILANOVA   (Spain)

^e University of Castilla La Mancha   (Spain)

Author keywords

BH3 only proteins; Cell death; Mitochondrial outer membrane permeability; Mitochondrion; Parkinson's disease; Permeability transition pore

Indexed keywords

6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; MITOGEN ACTIVATED PROTEIN KINASE 14; OXIDOPAMINE; PROTEIN BAX; PROTEIN P53; PUMA PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CYTOSOL; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; ENZYME INHIBITORS; FIBROBLASTS; GREEN FLUORESCENT PROTEINS; HUMANS; IMIDAZOLES; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL SWELLING; NEUROBLASTOMA; NEURONS; OXIDOPAMINE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS; SYMPATHOLYTICS; THIAZOLES; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 39849090617     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05115.x     Document Type: Article

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