Altered association of protein tyrosine kinases with postsynaptic densities after transient cerebral ischemia in the rat brain

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 3, 2000, Pages 505-512

  Cheung, Herman H ^c   Takagi, Norio ^b   Teves, Lucy ^c   Logan, Richard ^c   Wallace, M Christopher ^c   Gurd, James W ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^c NONE

Author keywords

Brain derived neurotrophic factor; NMDA receptor; PYK2; Src; Tyrosine phosphorylation

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POSTSYNAPTIC DENSITY PROTEIN; POSTSYNAPTIC RECEPTOR; PROLINE; PROTEIN TYROSINE KINASE; RECEPTOR SUBUNIT; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; MALE; NEUROMODULATION; NONHUMAN; POSTSYNAPTIC DENSITY; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DENSITY; TRANSIENT ISCHEMIC ATTACK;

EID: 0034064784     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200003000-00009     Document Type: Article

References (17)

1. Bhave SV, Ghoda L, Huffman PL (1999) Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: signal transduction cascades and site of ethanol action. J Neurosci 19:3277-3286
2. Campos-Gonzalez R, Kindy MS (1992) Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain. J Neurochem 59:1955-1958
3. Cho KO, Hunt CA, Kennedy MB (1992) The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9:929-942
4. Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J (1996) A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383:547-550
5. Gurd JW (1997) Protein tyrosine phosphorylation: implications for synaptic function. Neurochem Int 31:635-649
6. Gurd JW, Bissoon N (1997) The W-methyl-D-aspartate receptor subunits NR2A and NR2B bind to the SH2 domains of phospholipase C-τ. J Neurochem 69:623-630
7. Gurd JW, Bissoon N, Soulliere J (1992) Procedures for analysing the tyrosine phosphorylation of synaptic proteins. Neuroprotocols 1: 207-214
8. Hu BR, Wieloch T (1994) Tyrosine phosphorylation and activation of mitogen-activated protein kinase in the rat brain following transient cerebral ischemia. J Neurochem 62:1357-1367
9. Hu BR, Park M, Martone ME, Fischer WH, Ellisman MH, Zivin JA (1998) Assembly of proteins to postsynaptic densities after transient cerebral ischemia. J Neurosci 18:625-633
10. Huang YQ, Lu W-Y, Aoto H, Sasaki T, Salter MW, MacDonald JF (1999) Upregulation of NMDA receptor function by tyrosine kinase CAKbeta/Pyk2. Soc Neurosci Abstr 25:1978
11. Kennedy MB (1998) Signal transduction molecules at the glutamatergic postsynaptic membrane. Brain Res Brain Res Rev 26:243-257
12. Kindy MS (1993) Inhibition of tyrosine phosphorylation prevents delayed neuronal death following cerebral ischemia. J Cereb Blood Flow Metab 13:372-377
13. Kiprianova I, Freiman TM, Desiderato S, Schwab S, Galmbacher R, Gillardon F, Spranger M (1999) Brain-derived neurotrophic factor prevents neuronal death and glial activation after global ischemia in the rat. J Neurosci Res 1999 56:21-27
14. Köhr G, Seeberg PH (1996) Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinase of the src family. J Physiol 492:445-452
15. Takagi N, Shinno K, Teves L, Bissoon N, Wallace MC, Curd JW (1997) Transient ischemia differentially increases tyrosine phosphorylation of NMDA receptor subunits 2A and 2B. J Neurochem 69:1060-1065
16. Zhang L, Hsu JC, Takagi N, Gurd JW, Wallace MC, Eubanks JH (1997) Transient global ischemia alters NMDA receptor expression in rat hippocampus: correlation with decreased immunoreactive protein levels of the NR2A/2B subunits, and an altered NMDA receptor functionality. J Neurochem 69:1983-1994
17. Ziff EB (1997) Enlightening the postsynaptic density. Neuron 19: 1163-1174