Conserved glutamate residues Glu-343 and Glu-519 provide mechanistic insights into cation/nucleoside cotransport by human concentrative nucleoside transporter hCNT3

Journal of Biological Chemistry

Volumn 284, Issue 25, 2009, Pages 17266-17280

  Slugoski, Melissa D ^a   Smith, Kyla M ^a   Ng, Amy M L ^a   Yao, Sylvia Y M ^a   Karpinski, Edward ^a   Cass, Carol E ^a,b   Baldwin, Stephen A ^c   Young, James D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CROSS CANCER INSTITUTE   (Canada)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION KINETICS; ASPARTATE; CATALYTIC ACTIVITY; COMMON CATION; CONCENTRATIVE NUCLEOSIDE TRANSPORTERS; ELECTROCHEMICAL GRADIENTS; ELECTROPHYSIOLOGICAL TECHNIQUES; HETEROLOGOUS EXPRESSION; NUCLEOSIDE TRANSPORT; SITE DIRECTED MUTAGENESIS; TRANSPORT FUNCTION; XENOPUS OOCYTE;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; POSITIVE IONS; RADIOISOTOPES; STOICHIOMETRY;

BIOMOLECULES;

ASPARTIC ACID; CHLOROMERCURIBENZENESULFONIC ACID; CYSTEINE; GLUTAMIC ACID; GUANOSINE; HUMAN CONCENTRATIVE NUCLEOSIDE TRANSPORTER 3; NUCLEOSIDE TRANSPORTER; PROTON; UNCLASSIFIED DRUG; URIDINE;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BINDING SITE; CATALYSIS; CATION TRANSPORT; CELL SURFACE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENZYME INHIBITION; FEMALE; HETEROLOGOUS EXPRESSION; NONHUMAN; NUCLEOSIDE TRANSPORT; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; RADIOISOTOPE DISTRIBUTION; SITE DIRECTED MUTAGENESIS; SODIUM TRANSPORT; STOICHIOMETRY; TRANSLOCATION LINE;

4-CHLOROMERCURIBENZENESULFONATE; ANIMALS; BINDING, COMPETITIVE; CELL MEMBRANE; CONSERVED SEQUENCE; FEMALE; GLUTAMIC ACID; GUANOSINE; HUMANS; ION TRANSPORT; KINETICS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEOSIDES; OOCYTES; RECOMBINANT PROTEINS; SODIUM; URIDINE; XENOPUS;

EID: 67650553426     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.009613     Document Type: Article

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