Specific mutations in transmembrane helix 8 of human concentrative Na +/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling

Biochemistry

Volumn 46, Issue 6, 2007, Pages 1684-1693

  Slugoski, Melissa D ^a   Loewen, Shaun K ^a   Ng, Amy M L ^a   Smith, Kyla M ^a   Yao, Sylvia Y M ^a   Karpinski, Edward ^a   Cass, Carol E ^a   Baldwin, Stephen A ^b   Young, James D ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MUTATIONS; NUCLEOSIDES; PERMEANT SELECTIVITY; TRANSMEMBRANE;

AMINO ACIDS; BIOASSAY; MUTAGENESIS; POSITIVE IONS;

CELL MEMBRANES;

ADENOSINE; CARRIER PROTEIN; CATION; CHLOROMERCURIBENZENESULFONIC ACID; CYSTEINE; CYTIDINE; GLUTAMINE; GLYCINE; LEUCINE; LITHIUM ION; MEMBRANE PROTEIN; METHIONINE; MUTANT PROTEIN; NUCLEOSIDE TRANSPORTER; PROTEIN CNT1; PROTEIN CNT2; PROTEIN SUBUNIT; PURINE NUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; SERINE; SODIUM ION; THREONINE; UNCLASSIFIED DRUG; URIDINE; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CATION TRANSPORT; CONTROLLED STUDY; HUMAN; INDUCED MUTATION; NONHUMAN; NUCLEOSIDE TRANSPORT; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

4-CHLOROMERCURIBENZENESULFONATE; AMINO ACID SEQUENCE; ANIMALS; CATIONS, MONOVALENT; CYTIDINE; HUMANS; KINETICS; LEUCINE; LITHIUM; MEMBRANE TRANSPORT PROTEINS; PROTEIN STRUCTURE, SECONDARY; SERINE; SODIUM; SUBSTRATE SPECIFICITY; THYMIDINE; URIDINE; XENOPUS LAEVIS;

EID: 33846996334     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061692s     Document Type: Article

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