Regulatory cells, cytokine pattern and clinical risk factors for asthma in infants and young children with recurrent wheeze

Clinical and Experimental Allergy

Volumn 39, Issue 8, 2009, Pages 1160-1169

  Borrego, L M ^a   Arroz, M J ^b   Videira, P ^b   Martins, C ^b   Guimaraes H ^b   Nunes, G ^b   Papoila, A L ^c   Trindade, H ^b  

^a HOSPITAL DONA ESTEFÂNIA   (Portugal)

^b NOVA MEDICAL SCHOOL   (Portugal)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

Asthma; Child; Cytokine; Regulatory cells; Wheezing

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 10; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; STEROID; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC RHINITIS; ARTICLE; ASTHMA; CD4+ CD25+ T LYMPHOCYTE; CHILD; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHILIA; FEMALE; FLOW CYTOMETRY; HIGH RISK POPULATION; HUMAN; IMMUNE RESPONSE; INFANT; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT DISEASE; REGULATORY T LYMPHOCYTE; RISK FACTOR; WHEEZING;

ANIMALS; ANTIGENS, CD; ANTIGENS, DERMATOPHAGOIDES; ASTHMA; CYTOKINES; FLOW CYTOMETRY; HUMANS; INFANT; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; RESPIRATORY SOUNDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; TETRADECANOYLPHORBOL ACETATE;

EID: 67650526987     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2009.03253.x     Document Type: Article

References (52)

1. Clough JB, Keeping KA, Edwards LC et al. Can we predict which wheezy infants will continue to wheeze? Am J Respir Crit Care Med 1999 160 : 1473 80.
2. Martinez FD, Wright AL, Taussig LM et al. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med 1995 332 : 133 8.
3. Taussig LM, Wright AL, Holberg CJ et al. Tucson children's respiratory study: 1980 to present. J Allergy Clin Immunol 2003 111 : 661 75.
4. De Sario M, Di Domenicantonio R, Corbo G et al. Characteristics of early transient, persistent, and late onset wheezers at 9 to 11 years of age. J Asthma 2006 43 : 633 8.
5. Castro-Rodriguez JA, Holberg CJ, Wright AL et al. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000 162 : 1403 6.
6. von Mutius E. Influences in allergy: epidemiology and the environment. J Allergy Clin Immunol 2004 113 : 373 799.
7. Prescott SL, Macaubas C, Smallacombe T et al. Reciprocal age-related patterns of allergen specific T-cell immunity in normal vs atopic infants. Clin Exp Allergy 1998 28 (Suppl. 5 39 41, 50-1.
8. Rinas U, Horneff G, Wahn V. Interferon-gamma production by cord-blood mononuclear cells is reduced in newborns with a family history of atopic disease and is independent from cord blood Ig-E levels. Pediatr Allergy Immunol 1993 4 : 60 4.
9. Tang ML, Kemp AS, Thornburn G, Hill DJ. Reduced interferon-gamma in neonates and subsequent atopy. Lancet 1994 344 : 983 5.
10. Liao SY, Liao TN, Chiang BL et al. Decreased production of IFN gamma and increased production of IL-6 by cord blood mononuclear cells of newborns with high risk of allergy. Clin Exp Allergy 1996 26 : 397 405.
11. H1 mediated autoimmune disorders: lack of support for the hygiene hypothesis. J Allergy Clin Immunol 2003 111 : 131 5.
12. Wills-Karp M, Santeliz J, Karp CL. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol 2001 1 : 69 75. (Pubitemid 33741977)
13. Curotto de Lafaille MAC, Lafaille JJ. CD4+ regulatory T cells in autoimmunity and allergy. Curr Opin Immunol 2002 14 : 771 8.
14. Van Oosterhout AJ, Bloksma N. Regulatory T-lymphocytes in asthma. Eur Respir J 2005 26 : 918 32.
15. + regulatory T cells in birch allergics during birch pollen season. Clin Exp Allergy 2004 34 : 1364 72.
16. H2 cytokine production. J Allergy Clin Immunol 2003 111 : 862 8.
17. + regulatory cells that control intestinal inflammation. J Exp Med 2000 192 : 295 302. (Pubitemid 30470312)
18. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000 192 : 303 10.
19. + cells: a naturally occurring population of regulatory T cells. Blood 2001 98 : 2736 44.
20. + regulatory T cell function. Eur J Immunol 2004 34 : 2996 3005. (Pubitemid 39549379)
21. Paust S, Lu L, McCarty N, Cantor H. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci USA 2004 101 : 10398 403.
22. high regulatory cells in human peripheral blood. J Immunol 2001 167 : 1245 53.
23. high T cells and atopy in children. J Allergy Clin Immunol 2007 120 : 177 83.
24. + T cells. Clin Immunol 2005 115 : 10 8.
25. + T cells with regulatory propreties isolated from periphereal blood. J Exp Med 2001 193 : 1258 94.
26. + regulatory T cells at the single-cell level. Eur J Immunol 2005 35 : 1681 91.
27. hi regulatory T cells in pediatric asthma. J Allergy Clin Immunol 2007 119 : 1258 66.
28. T Method. Methods 2001 25 : 402 8.
29. Yuan JS, Reed A, Chen F, Stewart CN Jr. Statistical analysis of real-time PCR data. BMC Bioinformatics 2006 7 : 85.
30. Haddeland U, Karstensen AB, Farkas L et al. Putative regulatory T cells are impaired in cord blood from neonates with hereditary allergy risk. Pediatr Allergy Immunol 2005 16 : 104 12.
31. + T lymphocytes in peripheral blood from patients with atopic asthma. Clin Immunol 2004 113 : 172 8.
32. high T-regulatory cells in allergic asthma is subjected to TNF-alpha modulation. Allergy 2008 63 : 67 74.
33. Strickland DH, Stumbles PA, Zosky GR et al. Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells. J Exp Med 2006 203 : 2649 60.
34. + Tregs. J Clin Invest 2005 115 : 3276 84.
35. Ziegler SF. FOXP3: of mice and men. Annu Rev Immunol 2006 24 : 209 26.
36. + regulatory T cells. Nat Immunol 2003 4 : 330 6.
37. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003 299 : 1057 61.
38. H2-like population. J Allergy Clin Immunol 2008 121 : 415 22.
39. + T regulatory cells in humans. Hum Immunol 2005 66 : 13 20. (Pubitemid 40037706)
40. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003 198 : 1875 86.
41. Schaub B, Liu J, H S et al. Impairmente of T-regulatory cells in cord blood of atopic mothers. J Allergy Clin Immunol 2008 121 : 1491 9, 1499, e1-13.
42. Fu S, Zhang N, Yopp AC et al. TGF-beta induces Foxp3+ T-regulatory cells from CD4+CD25- precursors. Am J Transplant 2004 4 : 1614 27.
43. Yang YH, Chen MC, Tsai MJ, Lin YT, Chiang BL. Costimulatory molecules expression and cytokine profiles of cord blood mononuclear cells in newborns with low and high risk of developing atopic diseases. J Microbiol Immunol Infect 2000 33 : 159 64.
44. Koning H, Neijens HJ, Baert MR, Oranje AP, Savelkoul HF. T cells subsets and cytokines in allergic and non-allergic children. II. Analysis and IL-5 and IL-10 mRNA expression and protein production. Cytokine 1997 9 : 427 36.
45. Akdis M, Verhagen J, Taylor A et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004 199 : 1567 75.
46. Kjellman NI, Croner S. Cord blood IgE determination for allergy prediction - a follow-up to seven years of age in 1,651 children. Ann Allergy 1984 53 : 167 71.
47. Kondo N, Kobayashi Y, Shinoda S et al. Reduced interferon gamma production by antigen stimulated cord blood mononuclear cells is a risk factor of allergic disorders - 6-year follow-up study. Clin Exp Allergy 1998 28 : 1340 4.
48. Guerra S, Lohman IC, Halonen M, Martinez FD, Wright AL. Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age. Am J Respir Crit Care Med 2004 169 : 70 6.
49. van der Velden V, Laan MP, Baert MR, de Waal Malefyt R, Neijens HJ, Savelkoul HF. Selective development of a strong Th2 cytokine profile in high-risk children who develop atopy: risk factors and regulatory role of IFN-gamma, IL-4 and IL-10. Clin Exp Allergy 2001 31 : 997 1006. (Pubitemid 32862828)
50. Allakhverdi Z, Fitzpatrick D, Boisvert A et al. Expression of CD103 identifies human regulatory T-cell subsets. J Allergy Clin Immunol 2006 118 : 1342 9.
51. Liu W, Putnam AL, Xu-Yu Z et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD41 T reg cells. J Exp Med 2006 203 : 1701 11.
52. Seddiki N, Santner-Nanan B, Martinson J et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006 203 : 1693 700.