Reduced Interferon γ Production and Soluble CD14 Levels in Early Life Predict Recurrent Wheezing by 1 Year of Age

American Journal of Respiratory and Critical Care Medicine

Volumn 169, Issue 1, 2004, Pages 70-76

  Guerra, Stefano ^a,b   Lohman, I Carla ^a   Halonen, Marilyn ^a   Martinez, Fernando D ^a   Wright, Anne L ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Asthma; CD14 antigen; IFN ; LPS receptor; Wheezing

Indexed keywords

CD14 ANTIGEN; GAMMA INTERFERON;

ARTICLE; CELL STIMULATION; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; FEMALE; HUMAN; INFANT; MALE; MULTIVARIATE ANALYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYCLONAL ACTIVATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUESTIONNAIRE; RECURRENT DISEASE; WHEEZING;

EID: 1242298443     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200304-499oc     Document Type: Article

References (37)

1. Wright AL, Taussig LM, Ray CG, Harrison HR, Holberg CJ. The Tucson children's respiratory study. II: lower respiratory tract illness in the first year of life. Am J Epidemiol 1989;129:1232-1246.
2. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life: The Group Health Medical Associates. N Engl J Med 1995;332:133-138.
3. Oddy WH, de Klerk NH, Sly PD, Holt PG. The effects of respiratory infections, atopy, and breastfeeding on childhood asthma. Eur Respir J 2002;19:899-905.
4. Sears MR. Consequences of long-term inflammation: the natural history of asthma. Clin Chest Med 2000;21:315-329.
5. Hoekstra MO, Hoekstra Y, De Reus D, Rutgers B, Gerritsen J, Kauffman HF. Interleukin-4, interferon-gamma and interleukin-5 in peripheral blood of children with moderate atopic asthma. Clin Exp Allergy 1997;27:1254-1260.
6. Koning H, Neijens HJ, Baert MR, Oranje AP, Savelkoul HF. T cell subsets and cytokines in allergic and non-allergic children. I: analysis of IL-4, IFN-gamma and IL-13 mRNA expression and protein production. Cytokine 1997;9:416-426.
7. Leech SC, Price JF, Holmes BJ, Kemeny DM. Nonatopic wheezy children have reduced interferon-gamma. Allergy 2000;55:74-78.
8. Roman M, Calhoun WJ, Hinton KL, Avendano LF, Simon V, Escobar AM, Gaggero A, Diaz PV. Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. Am J Respir Crit Care Med 1997;156:190-195.
9. Aberle JH, Aberle SW, Dworzak MN, Mandl CW, Rebhandl W, Vollnhofer G, Kundi M, Popow-Kraupp T. Reduced interferon-gamma expression in peripheral blood mononuclear cells of infants with severe respiratory syncytial virus disease. Am J Respir Crit Care Med 1999;160:1263-1268.
10. Halonen M, Martinez FD. A deficient capacity to produce interferon-gamma: is it a risk for asthma and allergies? Clin Exp Allergy 1997;27:1234-1236.
11. Gereda JE, Leung DY, Thatayatikom A, Streib JE, Price MR, Klinnert MD, Liu AH. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000;355:1680-1683.
12. Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD. A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999;20:976-983.
13. Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999;354:SII12-SII15.
14. Guerra S, Lohman IC, Tebow G, Wright AL, Martinez FD, Halonen M. Soluble CD14 levels at birth as predictors of wheezing in the first year of life [abstract]. Allergy 2002;57(s73):41-42.
15. Brown H, Prescott R. Applied mixed models in medicine, statistics in practice. Chichester: John Wiley & Sons Ltd; 1999.
16. van Schaik SM, Tristram DA, Nagpal IS, Hintz KM, Welliver RC II, Welliver RC. Increased production of IFN-gamma and cysteinyl leukotrienes in virus-induced wheezing. J Allergy Clin Immunol 1999;103:630-636.
17. Landmann R, Zimmerli W, Sansano S, Link S, Hahn A, Glauser MP, Calandra T. Increased circulating soluble CD14 is associated with high mortality in gram-negative septic shock. J Infect Dis 1995;171:639-644.
18. Lien E, Aukrust P, Sundan A, Muller F, Froland SS, Espevik T. Elevated levels of serum-soluble CD14 in human immunodeficiency virus type 1 (HIV-1) infection: correlation to disease progression and clinical events. Blood 1998;92:2084-2092.
19. Nockher WA, Wick M, Pfister HW. Cerebrospinal fluid levels of soluble CD14 in inflammatory and non-inflammatory diseases of the CNS: upregulation during bacterial infections and viral meningitis. J Neuroimmunol 1999;101:161-169.
20. Dubin W, Martin TR, Swoveland P, Leturcq DJ, Moriarty AM, Tobias PS, Bleecker ER, Goldblum SE, Hasday JD. Asthma and endotoxin: lipopolysaccharide- binding protein and soluble CD14 in bronchoalveolar compartment. Am J Physiol 1996;270:L736-L744.
21. Braun-Fahrlander C, Riedler J, Herz U, Eder W, Waser M, Grize L, Maisch S, Carr D, Gerlach F, Bufe A, et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002;347:869-877.
22. Gehring U, Bischof W, Fahlbusch B, Wichmann HE, Heinrich J. House dust endotoxin and allergic sensitization in children. Am J Respir Crit Care Med 2002;166:939-944.
23. Riedler J, Braun-Fahrlander C, Eder W, Schreuer M, Waser M, Maisch S, Carr D, Schierl R, Nowak D, von Mutius E. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001;358:1129-1133.
24. Remes ST, Castro-Rodriguez JA, Holberg CJ, Martinez FD, Wright AL. Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. J Allergy Clin Immunol 2001;108:509-515.
25. Litonjua AA, Milton DK, Celedon JC, Ryan L, Weiss ST, Gold DR. A longitudinal analysis of wheezing in young children: the independent effects of early life exposure to house dust endotoxin, allergens, and pets. J Allergy Clin Immunol 2002;110:736-742.
26. Park JH, Gold DR, Spiegelman DL, Burge HA, Milton DK. House dust endotoxin and wheeze in the first year of life. Am J Respir Crit Care Med 2001;163:322-328.
27. Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000;1:398-401.
28. van Schaik SM, Obot N, Enhorning G, Hintz K, Gross K, Hancock GE, Stack AM, Welliver RC. Role of interferon gamma in the pathogenesis of primary respiratory syncytial virus infection in BALB/c mice. J Med Virol 2000;62:257-266.
29. Liao SY, Liao TN, Chiang BL, Huang MS, Chen CC, Chou CC, Hsieh KH. Decreased production of IFN gamma and increased production of IL-6 by cord blood mononuclear cells of newborns with a high risk of allergy. Clin Exp Allergy 1996;26:397-405.
30. Tang ML, Kemp AS, Thorburn J, Hill DJ. Reduced interferon-gamma secretion in neonates and subsequent atopy. Lancet 1994;344:983-985.
31. Martinez FD, Stern DA, Wright AL, Holberg CJ, Taussig LM, Halonen M. Association of interleukin-2 and interferon-gamma production by blood mononuclear cells in infancy with parental allergy skin tests and with subsequent development of atopy. J Allergy Clin Immunol 1995;96:652-660.
32. Kuehni CE, Davis A, Brooke AM, Silverman M. Are all wheezing disorders in very young (preschool) children increasing in prevalence? Lancet 2001;357:1821-1825.
33. Marbury MC, Maldonado G, Waller L. Lower respiratory illness, recurrent wheezing, and day care attendance. Am J Respir Crit Care Med 1997;155:156-161.
34. Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, Wright AL. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 2000;343:538-543.
35. Sherriff A, Peters TJ, Henderson J, Strachan D. Risk factor associations with wheezing patterns in children followed longitudinally from birth to 3(1/2) years. Int J Epidemiol 2001;30:1473-1484.
36. Martinez FD, Wright AL, Holberg CJ, Morgan WJ, Taussig LM. Maternal age as a risk factor for wheezing lower respiratory illnesses in the first year of life. Am J Epidemiol 1992;136:1258-1268.
37. Halonen M, Stern D, Taussig LM, Wright A, Ray CG, Martinez FD. The predictive relationship between serum IgE levels at birth and subsequent incidences of lower respiratory illnesses and eczema in infants. Am Rev Respir Dis 1992;146:866-870.