Testing the accelerator hypothesis: Body size, β-cell function, and age at onset of type 1 (autoimmune) diabetes: Response to Dabelea et al. [10]

Diabetes Care

Volumn 29, Issue 6, 2006, Pages 1462-1463

  Wilkin, Terence J ^a,b  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b DERRIFORD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; DNA;

AUTOIMMUNE DISEASE; BODY MASS; BODY SIZE; CELL FUNCTION; GENOTYPE; HLA SYSTEM; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; LETTER; PANCREAS ISLET CELL TUMOR;

BODY SIZE; DIABETES MELLITUS, TYPE 1; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL;

EID: 33746387907     PISSN: 01495992     EISSN: 01495992     Source Type: Journal    
DOI: 10.2337/dc06-0345     Document Type: Letter

References (9)

1. Dabelea D, D'Agostino RB Jr, Mayer-Davis EJ, Pettitt DJ, Imperatore G, Dolan LM, Pihoker C, Hillier TA, Marcovina SM, Linder B, Ruggiero AM, Hamman RF, the SEARCH for Diabetes in Youth Study Group: Testing the accelerator hypothesis: body size, β-cell function, and age at onset of type 1 (autoimmune) diabetes. Diabetes Care 29:290-294, 2006
2. Wilkin TJ: The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes. Diabetologia 44:914-922, 2001
3. Tait BD, Harrison LC, Drummond BP, Stewart V, Varney MD, Honeyman MC: HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus. Hum Immunol 42:116-122, 1995
4. Ehtisham S, Crabtree N, Clark P, Shaw N, Barrett T: Ethnic differences in insulin resistance and body composition in United Kingdom adolescents. J Clin Endocrinol Metab 90:3963-3969, 2005
5. Kibirige M, Metcalf B, Renuka R, Wilkin TJ: Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes. Diabetes Care 26:2865-2870, 2003
6. Betts P, Mulligan J, Ward P, Smith B, Wilkin T: Increasing body weight predicts the earlier onset of insulin-dependant diabetes in childhood: testing the 'accelerator hypothesis' (2). Diabet Med 22:144-151, 2005
7. Knerr I, Wolf J, Reinehr T, Stachow R, Grabert M, Schober E, Rascher W, Holl RW, the DPV Scientific Initiative of Germany and Austria: The 'accelerator hypothesis': relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus. Diabetologia 48:2501-2504, 2005
8. Kordonouri O, Hartmann R: Higher body weight is associated with earlier onset of type 1 diabetes: confirming the accelerator hypothesis (Letter). Diabet Med 22: 1783-1784, 2005
9. Fourlanos S, Narendran P, Byrnes GB, Colman PG, Harrison LC: Insulin resistance is a risk factor for progression to type 1 diabetes. Diabetologia 47:1661-1667, 2004