The accelerator hypothesis cannot be tested using the type 2 diabetes gene, TCF7L2 [1]

Diabetologia

Volumn 50, Issue 8, 2007, Pages 1780-

  Wilkin, T J ^a,b  

^a PENINSULA MEDICAL SCHOOL   (United Kingdom)

^b DERRIFORD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; PROTEIN; TRANSCRIPTION FACTOR 7 LIKE 2 PROTEIN; UNCLASSIFIED DRUG;

DISEASE ASSOCIATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HLA SYSTEM; HUMAN; HYPOTHESIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; LETTER; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; POPULATION RISK; PRIORITY JOURNAL;

DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; HUMANS; TCF TRANSCRIPTION FACTORS;

EID: 34447131684     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0725-x     Document Type: Letter

References (5)

1. Field SF, Howson JMM, Smyth DJ, Walker NM, Dunger DB, Todd JA (2007) Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects. Diabetologia 50:212-213
2. Wilkin TJ (2001) The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes. Diabetologia 44:914-922
3. Grant SF, Thorleifsson G, Reynisdottir I et al (2000) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323
4. Hermann R, Knip M, Veijola R et al (2003) Temporal changes in the frequencies of HLA genotypes in patients with type I diabetes-indication of an increased environmental pressure? Diabetologia 46:420-425
5. Gillespie KM, Bain SC, Barnett AH et al (2004) The rising incidence of type 1 diabetes is associated with a reduced contribution from high-risk HLA haplotypes. Lancet 364:1699-1700