Synthesis of 2-methylindoline- and 2-methyl-1,2,3,4-tetrahydroquinoline- derived phosphoramidites and their applications in iridium-catalyzed allylic alkylation of indoles

Synthesis

Volumn , Issue 12, 2009, Pages 2076-2082

  Liu, Wen Bo ^a   He, Hu ^a   Dai, Li Xin ^a   You, Shu Li ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Allylic alkylation; Friedel Crafts reaction; Indoles; Iridium; Phosphoramidites

Indexed keywords

ALLYLIC ALKYLATION; ALLYLIC CARBONATES; ENANTIOPURE; INDOLES; PHOSPHORAMIDITE LIGANDS; PHOSPHORAMIDITES; TETRAHYDROQUINOLINE;

ALKYLATION; CARBONATES; ENANTIOSELECTIVITY; FRIEDEL-CRAFTS REACTION; HYDROCARBONS; IRIDIUM; SYNTHESIS (CHEMICAL);

LIGANDS;

1,2,3,4 TETRAHYDRO 2 METHYLQUINOLINE; 2 METHYLINDOLINE; 3 [1(2 BROMOPHENYL)ALLYL] 1H INDOLE; 3 [1(2 CHLOROPHENYL)ALLYL] 1H INDOLE; 3 [1(2 METHOXYPHENYL)ALLYL] 1H INDOLE; 3 [1(4 BROMOPHENYL)ALLYL] 1H INDOLE; 3 [1(4 METHOXYPHENYL)ALLYL] 2 PHENYL 1H INDOLE; 3 [1(4 TRIFLUOROMETHYL)PHENYL)ALLYL] 1H INDOLE; 3[1(4 METHOXYPHENYL)ALLYL] 1H INDOLE; 5 METHOXY 3 [1 (NAPHTHALEN 1 YL)ALLYL] 1H INDOLE; 5 METHOXY 3 [1(4 METHOXYPHENYL)ALLYL] 1H INDOLE; CARBONIC ACID DERIVATIVE; CINNAMYL CARBONATE; INDOLE DERIVATIVE; IRIDIUM; O,O' [1,1' DINEPHTHYL 2,2' DIYL] N [2 METHYL 1,2,3,4 TETRAHYDROQUINOLINE]PHOSPHORAMIDITE; O,O' [1,1' DINEPHTHYL 2,2' DIYL] N [2 METHYLINDOLINELPHOSPHORAMIDITE; PHOSPHORAMIDOUS ACID DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENANTIOMER; ENANTIOSELECTIVITY; FRIEDEL CRAFTS REACTION; SUBSTITUTION REACTION; SYNTHESIS; X RAY ANALYSIS;

EID: 67650082845     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0029-1216823     Document Type: Article

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