Iridium-catalyzed asymmetric allylic substitutions-very high regioselectivity and air stability with a catalyst derived from dibenzo[a,e]cyclooctatetraene and a phosphoramidite

Angewandte Chemie - International Edition

Volumn 47, Issue 40, 2008, Pages 7652-7655

  Spiess, Stephanie ^a   Welter, Carolin ^a   Franck, Géraldine ^a   Taquet, Jean Philippe ^a   Helmchen, Günter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Allylic amines; Allylic substitution; Asymmetric catalysis; Cyclization; Iridium

Indexed keywords

EID: 54749126182     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200802480     Document Type: Article

References (20)

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11. Most of the substitution reactions using the cod-containing catalyst have already been reported (see Refs. [3-5] in the Supporting Information). Nevertheless, these reactions were repeated side by side with the reactions promoted by the new dbcot-containing catalyst in order to ensure identical reaction conditions.
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18. Crystal data for K1: See the Supporting Information.
19. 31P NMR spectrum showed a broadened signal for the doublet at 142 ppm.
20. 3J = 78 Hz (6%) for diastereomers of type K2 derived from L1, cf. Ref. [11].